NSAIDs

Question 1

What is the primary clinical use for Ibproufen/Advil?

Answer 1

Anti-inflammatory

Question 2

What NSAID is contraindicated in pregnancy due to its abortive effects?

Answer 2

Misoprostol

Question 3

How can an OD of aspirin be treated?

Answer 3

Alkalinization of the urine to increase the rate of excretion

Question 4

What is the MOA of acetaminophen?

Answer 4

Weak COX1 & 2 inhibitor

Question 5

What enzyme is acted upon by NSAIDs?

Answer 5

COX1 & 2

Question 6

What drug should be administered in the case of Acetametophin OD?

Answer 6

Acetylcysteine - acts as a glutathione substitute

Question 7

What NSAID is contraindicated in patients with hemophilia?

Answer 7

Aspirin due to its antiplatelet action

Question 8

What NSAID is a COX2-specific inhibitor?

Answer 8

Celecoxib

Question 9

What NSAID metabolite is responsible for its pharmacological action?

Answer 9

Salicylate

Question 10

What is the MOA of NSAIDs?

Answer 10

Inhibits prostaglandin synthesis to inhibit inflammation

Question 11

What NSAID treats mild to moderate pain and may be used in combination with opioids to reduce their dose?

Answer 11

Ketorolac / Toradol

Question 12

What NSAID is contraindicated in patients with a sulfur allergy?

Answer 12

Celecoxib

Question 13

What is the MOA of aspirin?

Answer 13

Irreversibly inhibits COX1

Question 14

Nonspecific NSAIDs inhibit both COX1 & 2. What is the result of this non-specific action?

Answer 14

Inhibition of COX1 inhibits mucus production in the stomach. THis can lead to gastric ulcers and GI issues

Question 15

A patient with hemophilia and a history of gastric ulcers has a fever. What NSAID would their doctor recommend taking?

Answer 15

Acetaminophen

Question 16

Why are COX2-selective inhibitors associated with CV issues?

Answer 16

COX2 is associated with vasodilation and antiplatelet action. Inhibition causes the vasoconstrictive and pro-coagulation action of COX1 to predominate. This increases the risk of thrombosis

Question 17

What is the effect of the coadministration of Aspirin and Ibuprofen?

Answer 17

The antiplatelet action of Aspirin is reduced, thus reducing its therapeutic effectiveness

Question 18

Some COX2-inhibiting NSAIDs were pulled from the market in Phase 4 Clinical Trials. Why was this?

Answer 18

Due to their adverse CV effects

Question 19

What are the clinical uses of Acetametophin?

Answer 19

Analgesic & antipyretic - no anti-inflammatory effects

Question 20

What is the clinical use for aspirin?

Answer 20

Since aspirin irreversibly inhibits COX1, it is rarely used as an anti-inflammatory. It is commonly used as an antiplatelet, with minimal side effects

Question 21

What form of salicylates are best for patients with renal insufficiency?

Answer 21

Nonacetylated salicylates (not Aspirin)

Question 22

True/False. The addition of fluoride groups makes a molecule more potent.

Answer 22

True

Question 23

Most NSAIDs are highly protein bound (98%). What is the exception to this?

Answer 23

Aceptametophin (5% protein bound)