Rhodococcus and Corynebacterium Flashcards
what does Rhodococcus look like under a microscope with a gram stain?
gram positive
has both cocci and rods, depending on what stage it is
what are two organisms that cause granulomas or abscesses in horses?
Streptococcus equi
Rhodococcus equi
where does Rhodococcus replicate?
intracellularly in macrophages
who does Rhodococcus equi impact with pneumonia?
foals <6 months old
what makes up the pneumonia caused by Rhodococcus equi?
pulmonary abscessation and suppurative lymphadenitis
what is insufficient in foals less than 6 months that allows Rhodococcus equi to persist?
Th1 response
allows to replicate in macrophages and spread that way
how does Rhodococcus equi impact macrophages?
prevents fusion of phagosome lysosome
what is really important for Rhodococcus equi’s ability to grow and replicate in macrophages?
VapA protein: cannot grow without
what does Corynebacterium pseudotuberculosis cause?
caseous lymphadenitis in sheep and goats
ulcerative lymphangitis in horses and cattle
when should you treat foals with Rhodococcus equi?
when they have abscesses and are symptomatic
not when just have abscesses: resistance, will resolve itself usually
what is the appearance of Corynebacterium pseudotuberculosis with a gram stain under a microscope?
gram positive
cocci and rods
how can you get diarrhea with Rhodococcus equi infection?
infects Peyers patches
what are some similarities between Rhodococcus equi and Corynebacterium pseudotuberculosis?
zoonotic
soil dwellers
abscess-forming
intracellular pathogens that survive in macrophages
cocci and rods
what does Corynebacterium pseudotuberculosis cause in sheep and goats?
caseous lymphadenitis
what does Corynebacterium pseudotuberculosis cause in horses and cattle?
ulcerative lymphangitis
