Intracellular Bacteria Flashcards
where does the family Chlamydiaceae multiply?
vacuoles in eukaryotic cells
the infectious extracellular form, called the ____________________, initiates infection by attaching to an inducing uptake by the host cell
elementary body (EB)
one internalized, the bacteria remain within a membrane-bound vacuole where the organism differentiates into a more metabolically active form called the ________________________
reticulate body (RB)
are Rickettsiaceae obligate intracellular?
yes
Rickettsiaceae are commonly carried and transmitted by _______________________________________
arthropods like ticks, mites, lice, or fleas
what cells do Rickettsiaceae preferentially infect?
vascular endothelium
which Rickettsiaceae species is sgnificantly associated with animal disease?
Rickettsia rickettsii
what is the agent of rocky mountain spotted fever?
Rickettsia rickettsii
what is Coxiella burnetii the agent of?
Q fever
what are the primary reservoirs of Coxiella burnetii?
cattle
sheep
goats
how are Coxiella burnetii excreted?
milk
urine
feces
what is the disease like caused by Chlamydiaceae?
variable: clinically inapparent to severe systemic infections (fever, anorexia, lethargy, occasionally death)
what does Chlamydophila abortus cause?
enzootic abortion in ewes
also goats, cattle, pigs
pregnant women
what is Chlamydophila pecorum responsible for in farm animals?
polyarthritis and polyserositis in sheep, cattle, other animals
sporadic bovine encephalomyelitis
with Chlamydophila pecorum, both ________________________ tissue changes can be seen in the joints
periarticular and articular
what does Chlamydophila felis cause?
conjunctivitis in cats
what does Chlamydophila psittaci cause?
avian chlamydiosis: fibrinous serositis of body cavities, air sacs, and organ surfaces
lung, liver, spleen are enlarged and congested
what diseases does Chlamydophila psittaci cause?
ornithosis
psittacosis
avain chlamydiosis
what was the level of infection found with Chlamydophila pecorum and C. pneumoniae found in wild koalas?
C. pecorum ranged from low to high grade
C. pneumoniae always low grade
what is the drug of choice for chlamydial infections?
tetracycline
what is trachoma?
disease caused my Chlamydia trachomatis
leading cause of preventable blindness
what does Chlamydophila pecorum cause in koalas?
inflammatory and fibrotic disease in the eye and the urogenital and reproductive tracts in koalas
what carries Rickettsia rickettsii?
20 species of ixodid ticks
how do ticks become infected with Rickettsia rickettsii?
female can transmit to eggs transovarially
feed on blood from host in larval or nymphal stage
male ticks can transfer to females during mating
what are the early signs of Rickettsia rickettsii?
high fever
vomiting
diarrhea
hemorrhagic mucous membranes
where do Coxiella burnetii replicate?
inside phagolysosome
phagosome-containing bacteria within cell fuse with lysosomes to form
what is unique about the reproductive cycle of Chlamydiaceae?
infectious and reproductive forms are morphologically distinct
what are the two genera in Chlamydiaceae?
Chlamydia
Chlamydophila
what is usually present in the enzootic abortion of ewes caused by Chlamydophila abortus?
necrosis of cotyledonss and edema of intercotyledon tissue
dirty pink uterine exudate
what is sporadic bovine encephalomyelitis caused by?
Chlamydophila pecorum
does Chlamydophila psittaci cause fibrinous serositis?
yes
what is the more pathogenic Chlamydophila spp that infect koalas?
C. pecorum
