Diseases Due to Gram Negative Rods III Flashcards

1
Q

what are the symptoms of Salmonella pullorum?

A

white diarrhea or white pasty plug at vent

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2
Q

do opportunistic Enterobacteriaceae usually cause enteric disease?

A

no

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3
Q

what are the virulence factors of Klebsiella pneumoniae?

A

capsule
siderophores
adhesions
endotoxins (LPS): release from dead bacteria

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4
Q

what do siderophores do?

A

chelate and transport iron to bacteria

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5
Q

what is a pathogenic microbe that causes coliform mastitis?

A

Yersinia enterocolitica

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6
Q

what are some opportunistic microbes that cause coliform mastitis?

A

Klebsiella pneumoniae
Enterobacter aerogenes
Escherichia coli

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7
Q

are Klebsiella pneumoniae flagellated or not?

A

non-flagellated

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8
Q

what does Pseudomonas aeruginosa cause in sheep?

A

mastitis
fleece rot
pneumonia
rhinitis
otitis

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9
Q

what does Pseudomonas aeruginosa cause in farmed mink?

A

pneumonia
septicemia
extremely susceptible

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10
Q

how does Pseudomonas aeruginosa enter a body?

A

contact with contaminated devices, water, environment

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11
Q

what causes glanders in horses?

A

Burkholderia mallei

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12
Q

who is susceptible to Burkholderia mallei?

A

humans
goats
carnivores
equidae

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13
Q

who does Burkholderia pseudomallei infect?

A

pigs
goats
sheep

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14
Q

what do the clinical signs of Burkholderia pseudomallei vary with?

A

site of lesions

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15
Q

how does glanders/Burkholderia mallei infect people?

A

cuts, scrapes
mucosal surfaces of nose and eyes

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16
Q

how does meliodosis/Burkholderia pseudomallei infect humans?

A

inhalation of contaminated dust or water droplets
ingestion contaminated water
ingestion of soil-contaminated food
other contact with contaminated soil

17
Q

how common is person-to-person transmission of glanders and melioidosis?

A

rare

18
Q

is Aeromonas hydrophila opportunistic?

A

yes

19
Q

what is the mortality rate of Salmonella pullorum?

A

high

20
Q

who does Salmonella pullorum impact?

A

young chicks and turkeys

21
Q

how do opportunistic Enterobacteriaceae cause infections?

A

inherently vulnerable organs/systems
wounds and necrotic tissue
tissues taken by other infections
septicemia in immunocompromised

22
Q

what does inflammation cause with iron?

A

shifts from circulation into storage
hypoferremia and iron-deficient erythropoiesis (iron deficiency without anemia)

23
Q

what can Klebsiella pneumonia cause? four things

A

coliform mastitis: cows>sows
endometritis: mares
pneumonia: calves, foals
UTI: dogs

24
Q

does Pseudomonas aeruginosa cause a narrow or wide range of diseases?

A

wide range many species

25
Q

what is the pathogenesis of Pseudomonas aeruginosa?

A

entry via contact with contaminated water, devices, environment
breach in host defenses
adherence
colonization and replication
tissue damage

26
Q

how does Pseudomonas aeruginosa cause tissue damage?

A

toxin production: exoenzyme S (T3SS) and T2SS

27
Q

how does Pseudomonas aeruginosa cause localized damage?

A

exotoxin A: disrupts protein synthesis
phospholipase C: hemolysis
proteases: cell damage

28
Q

how does Pseudomonas aeruginosa cause systemic damage?

A

exoenzyme S (T3SS): inhibits DNA synthesis, alters cytoskeleton, microvillus effacement, antiphagocytic
exotoxin A
endotoxin: inflammation

29
Q

are Burkholderia mallei and Burkholderia pseudomallei intracellular or extracellular?

A

intracellular

30
Q

are Burkholderia spp zoonotic?

A

yes

31
Q

what is the acute form of Burkholderia mallei/glanders?

A

septicemia, fever
mucopurulent nasal discharge
respiratory difficulty
death within weeks

32
Q

what is the chronic form of Burkholderia mallei/glanders?

A

disseminated, debilitating disease
nasal, pulmonary, cutaneous
fatal after a few months
survivors are carriers

33
Q

how is Burkholderia mallei controlled?

A

test and slaughter

34
Q

who does Aeromonas hydrophila infect?

A

aquatic species
domestic animals
zoonosis