Respiratory I

Question 1

diphenhydramine

Answer 1

1st gen antihistamine

Question 2

demenhydrinate

Answer 2

1st gen antihistamine

Question 3

chlorpheniramine

Answer 3

1st gen antihistamine

Question 4

H1 blocker

Answer 4

reversible inhibitor H1 receptors

Question 5

loratadine

Answer 5

2nd gen antihistamine

Question 6

fexofenadine

Answer 6

2nd gen antihistamine

Question 7

desloratadine

Answer 7

2nd gen antihistamine

Question 8

cetirizine

Answer 8

2nd gen antihistamine

Question 9

adverse 1st gen antihistamine

Answer 9

sedation
antimuscarinic
anti-a-adrenergic

Question 10

adverse 2nd gen antihistamine

Answer 10

far less - decreased entry to CNS

Question 11

guaifenesin

Answer 11

expectorant - thins resp secretion

Question 12

N-acetylcysteine

Answer 12

mucolytic - loosen mucous plug CF - disrupt disulfide bonds

also used antidote acetaminophen OD

Question 13

dextromethorphan

Answer 13

antagonist NMDA receptor - glutamate

antitussive

synthetic codeine analog - mild opioid effects

Question 14

pseudoephedrine

Answer 14

a-adrenergic agonist

nasal decongestant

Question 15

phenylephrine

Answer 15

a-adrenergic agonist

nasal decongestant

Question 16

adverse a-adrenergic agonists

Answer 16

HTN

Question 17

bosentan

Answer 17

endothelin receptor antagonist

decreased pulmonary vascular resistance

Question 18

sildenafil

Answer 18

PDE-5 inhibitor
-inhibit cGMP and prolong vasodilation of NO

tx ED and pulmonary HTN

Question 19

epoprostenol

Answer 19

prostacyclin analog

vasodilatory effect

tx pulmonary HTN

Question 20

iloprost

Answer 20

prostacyclin analog

Question 21

adverse prostacyclin analogs

Answer 21

flushing

jaw pain

Question 22

albuterol

Answer 22

short acting beta2 agonist

Question 23

salmeterol

Answer 23

long acting beta2 agonist

Question 24

formoterol

Answer 24

long acting beta 2 agonist

Question 25

fluticasone

Answer 25

corticosteroid inactivate NF-kB - decresed TNF-a 1st line tx chronic asthma

Question 26

budesonide

Answer 26

corticosteroid inactivate NF-kB - decresed TNF-a 1st line tx chronic asthma

Question 27

ipratropium

Answer 27

muscarinic antagonist prevent bronchoconstriction -asthma drug

Question 28

tiotropium

Answer 28

long acting muscarinic antagonist

Question 29

montelukast

Answer 29

anti-leukotriene aspirin induced asthma tx

Question 30

zafirlukast

Answer 30

anti-leukotriene aspirin induced asthma tx

Question 31

zileuton

Answer 31

5-lipoxygenase pathway inhibitor block converstion arachidonic acid to leukotriene hepatotoxic

Question 32

omalizumab

Answer 32

monoclonal IgE Ab | tx allergic asthma

Question 33

theophylline

Answer 33

methylxanthine causes bronchodilation - inhibit phosphodiesterase - increased cAMP

Question 34

asthma early and late response

Answer 34

early - bronchoconstriction | late - inflammation

Question 35

adverse theophylline

Answer 35

cardiotoxic neurotoxic narrow therapeutic window block action of adenosine

Question 36

ACh and adenosine

Answer 36

promote bronchoconstriction

Question 37

methacholine

Answer 37

M3 agonist | -used in bronchial challenge test - help diagnose asthma