Respiratory I Flashcards by Matt Stanton

Q

diphenhydramine

A

1st gen antihistamine

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Q

demenhydrinate

A

1st gen antihistamine

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Q

chlorpheniramine

A

1st gen antihistamine

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Q

H1 blocker

A

reversible inhibitor H1 receptors

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Q

loratadine

A

2nd gen antihistamine

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Q

fexofenadine

A

2nd gen antihistamine

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Q

desloratadine

A

2nd gen antihistamine

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Q

cetirizine

A

2nd gen antihistamine

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Q

adverse 1st gen antihistamine

A

sedation
antimuscarinic
anti-a-adrenergic

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Q

adverse 2nd gen antihistamine

A

far less - decreased entry to CNS

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Q

guaifenesin

A

expectorant - thins resp secretion

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Q

N-acetylcysteine

A

mucolytic - loosen mucous plug CF - disrupt disulfide bonds

also used antidote acetaminophen OD

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Q

dextromethorphan

A

antagonist NMDA receptor - glutamate

antitussive

synthetic codeine analog - mild opioid effects

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Q

pseudoephedrine

A

a-adrenergic agonist

nasal decongestant

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Q

phenylephrine

A

a-adrenergic agonist

nasal decongestant

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Q

adverse a-adrenergic agonists

A

HTN

Q

bosentan

A

endothelin receptor antagonist

decreased pulmonary vascular resistance

Q

sildenafil

A

PDE-5 inhibitor
-inhibit cGMP and prolong vasodilation of NO

tx ED and pulmonary HTN

Q

epoprostenol

A

prostacyclin analog

vasodilatory effect

tx pulmonary HTN

Q

iloprost

A

prostacyclin analog

Q

adverse prostacyclin analogs

A

flushing

jaw pain

Q

albuterol

A

short acting beta2 agonist

Q

salmeterol

A

long acting beta2 agonist

Q

formoterol

A

long acting beta 2 agonist

Q

fluticasone

A

corticosteroid

inactivate NF-kB - decresed TNF-a

1st line tx chronic asthma

Q

budesonide

A

corticosteroid

inactivate NF-kB - decresed TNF-a

1st line tx chronic asthma

Q

ipratropium

A

muscarinic antagonist

prevent bronchoconstriction
-asthma drug

Q

tiotropium

A

long acting muscarinic antagonist

Q

montelukast

A

anti-leukotriene

aspirin induced asthma tx

Q

zafirlukast

A

anti-leukotriene

aspirin induced asthma tx

Q

zileuton

A

5-lipoxygenase pathway inhibitor

block converstion arachidonic acid to leukotriene

hepatotoxic

Q

omalizumab

A

monoclonal IgE Ab

tx allergic asthma

Q

theophylline

A

methylxanthine

causes bronchodilation

inhibit phosphodiesterase
increased cAMP

Q

asthma early and late response

A

early - bronchoconstriction

late - inflammation

Q

adverse theophylline

A

cardiotoxic
neurotoxic

narrow therapeutic window

block action of adenosine

Q

ACh and adenosine

A

promote bronchoconstriction

Q

methacholine

A

M3 agonist

-used in bronchial challenge test - help diagnose asthma