Neuro II

Question 1

phenobarbitol

Answer 1

barbituate

Question 2

pentobarbital

Answer 2

barbituate

Question 3

thiopental

Answer 3

barbituate

Question 4

secobarbital

Answer 4

barbituate

Question 5

barbiutate

Answer 5

facilitate GABA-A action
-increased DURATION of Cl- channel opening

decrease neuroin firing

bArbituAte - durAtion

Question 6

adverse barbituate

Answer 6

resp/cardiac depression

P450 inducer

OC - supportive tx

Question 7

chlordiazepoxide

Answer 7

benzodiazepine

Question 8

benzodiazepine

Answer 8

faciliate GABA-A activityion
-increase FREQUENCY of Cl- channel opening

bEnzo - frEquEncy

Question 9

short acting benzos

Answer 9

ATOM

alprazolam
triazolam
oxazepam
midazolam

higher risk of addiction

Question 10

adverse benzos

Answer 10

dependence

CNS depression - with alcohol

Question 11

tx OD benzos

Answer 11

flumazenil

Question 12

flumazenil

Answer 12

competitive antagonist at GABA benzo receptor

Question 13

zolpidem

Answer 13

non-benzo hypnotic

Question 14

zaleplon

Answer 14

non-benzo hypnotic

Question 15

eszopiclone

Answer 15

non-benzo hypnotic

Question 16

non-benzo hypnotics

Answer 16

activia BZ1 subtype GABA receptor

effect - reversed by flumazenil

Question 17

MAC

Answer 17

minimal alveolar concentration
-to prevent 50% subjects response to painful stimuli

measure of potency

Question 18

anesthetic decreased solubility in blood

Answer 18

rapid induction and recovery

Question 19

anesthetic increased solubility in lipid

Answer 19

increased potency

Question 20

nitrous oxide

Answer 20

low blood and lipid solubility

-fast induction - low potency

Question 21

halothane

Answer 21

high blood and lipid solubility

-slow induction - high potency

Question 22

halothane

Answer 22

inhaled anesthetic

unknown MOA

Question 23

enflurane

Answer 23

inhaled anesthetic

unknown MOA

Question 24

isoflurane

Answer 24

inhaled anesthetic

unknown MOA

Question 25

sevoflurane

Answer 25

inhaled anesthetic

unknown MOA

Question 26

methoxyflurane

Answer 26

inhaled anesthetic

unknown MOA

Question 27

N2O

Answer 27

inhaled anesthetic

unknown MOA

Question 28

malignant hyperthermia

Answer 28

with inhaled anesthetic and succinycholine

hyperthermia and muscle contraction

tx - dantrolene

Question 29

tx malignant hyperthermia

Answer 29

dantrolene - acts on RyR

Question 30

thiopental metabolism

Answer 30

terminated action

-by REDISTRIBUTION to tissues

Question 31

tx OD benzo

Answer 31

flumazenil

Question 32

midazolam

Answer 32

MC drug for anesthesia during endoscopy

Question 33

ketamine

Answer 33

arylcyclohexylamine

PCP analog - dissociative anesthetic

block NMDA receptor

cardiovasc stimulant
-disorientation, hallucinations, bad dreams

Question 34

propofol

Answer 34

for sedation in ICU
-rapid anesthesia induction

potentiate GABA-A

Question 35

procaine

Answer 35

ester local anesthetic

Question 36

cocaine

Answer 36

ester local anesthetic

Question 37

tetracaine

Answer 37

ester local anesthetic

Question 38

lidocaine

Answer 38

amide local anesthetic

Question 39

mepivicaine

Answer 39

amide local anesthetic

Question 40

bupivicaine

Answer 40

amide local anesthetic

Question 41

local anesthetic

Answer 41

block Na channels
-bind receptors on inner portion of channels

prefer bind activated Na channels

sometimes given with vaosoconstrictor - epinephrine

Question 42

infected acidic tissue

Answer 42

need more anesthetic

Question 43

order of nerve blockade speed

Answer 43

small diameter faster
myelinated faster
size over myelination

small myelinated > small unmyelinated > large myelinated > large unmyelinated

Question 44

order of loss with local anesthetic

Answer 44

1 pain
2 temp
3 touch
4 pressure

Question 45

adverse benzocaine

Answer 45

methemoglobinemia

Question 46

adverse bupivicaine

Answer 46

cardiovascular toxicity