Neuro II Flashcards
phenobarbitol
barbituate
pentobarbital
barbituate
thiopental
barbituate
secobarbital
barbituate
barbiutate
facilitate GABA-A action
-increased DURATION of Cl- channel opening
decrease neuroin firing
bArbituAte - durAtion
adverse barbituate
resp/cardiac depression
P450 inducer
OC - supportive tx
chlordiazepoxide
benzodiazepine
benzodiazepine
faciliate GABA-A activityion
-increase FREQUENCY of Cl- channel opening
bEnzo - frEquEncy
short acting benzos
ATOM
alprazolam
triazolam
oxazepam
midazolam
higher risk of addiction
adverse benzos
dependence
CNS depression - with alcohol
tx OD benzos
flumazenil
flumazenil
competitive antagonist at GABA benzo receptor
zolpidem
non-benzo hypnotic
zaleplon
non-benzo hypnotic
eszopiclone
non-benzo hypnotic
non-benzo hypnotics
activia BZ1 subtype GABA receptor
effect - reversed by flumazenil
MAC
minimal alveolar concentration
-to prevent 50% subjects response to painful stimuli
measure of potency
anesthetic decreased solubility in blood
rapid induction and recovery
anesthetic increased solubility in lipid
increased potency
nitrous oxide
low blood and lipid solubility
-fast induction - low potency
halothane
high blood and lipid solubility
-slow induction - high potency
halothane
inhaled anesthetic
unknown MOA
enflurane
inhaled anesthetic
unknown MOA
isoflurane
inhaled anesthetic
unknown MOA