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Board Review - B - Systems Pharmacology > Repro I > Flashcards

Repro I Flashcards

1
Q

leuprolide

A

GnRH agonist - pulsatile

GnRH antagonist - continuous

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2
Q

infertility tx

A

leuprolide - pulsatile

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3
Q

ethinyl estradiol

A

estrogen

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4
Q

DES

A

estrogen

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5
Q

mestranol

A

estrogen

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6
Q

HRT in post menopause women

A

estrogen

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7
Q

adverse estrogen therapy

A

increase risk endometrial cancer

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8
Q

exposure to DES in utero

A

clear cell adenocarcinoma of vagina risk

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9
Q

CI for estrogen therapy

A

ER+ breast cancer

history of DVTs

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10
Q

tx androgen dependent prostate cancer

A

estrogens

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11
Q

clomiphene

A 
SERM
antagonist estrogen receptor in hypothalamus
-prevent normal feedback inhibition
-increased release of LH and FSH
-stimulates ovulation
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12
Q

tx infertility due to anovulation

A

clomiphene

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13
Q

tamoxifen

A

SERM
antagonist breast
agonist bone and uterus

tx and prevent recurrence ER/PR + breast cancer

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14
Q

raloxifene

A

SERM
antagonist breast, uterus
agonist bone

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15
Q

adverse tamoxifen

A

increased risk of thromboembolic event and endometrial cancer

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16
Q

aderse raloxifene

A

increased risk thromboembolic event

NO increased risk endometrial cancer
-antagonist at uterus

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17
Q

anastrozole

A

aromatase inhibitor

tx ER + breast cancer

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18
Q

exemestane

A

aromatase inhibitor

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19
Q

progestin

A

bind progesterone receptor

decreased growth and increased vasc of endometrium

20
Q

hormone replacement therapy

A

relief sx of post-menopause

osteoporosis - more estrogen - decrease osteoclasts

21
Q

unopposed estrogen therapy

A

increased risk endometrial cancer

-so combine with progesterone

22
Q

mifepristone

A

RU-486

competitive inhibitor of progestins at progesterone receptor

23
Q

termination of pregnancy

A

mifepristone - RU-486 - progesterone receptor inhibitor

misoprostol - PGE1 - prostaglandin

24
Q

oral contraception

A

estrogen and progestins

  • inhibit LH/FSH - prevent estrogen surge
  • no LH surge - no ovulation

progestins - also - thick cervical mucus and inhibit endometrial proliferation

25
Q

CI for oral contraception

A

smoker >35yo

hx of thromboembolism or stroke

26
Q

terbutaline

A

beta2 agonist

relax uterus contractions

27
Q

ritodrine

A

beta2 agonist

relax uterus contraction

28
Q

danazol

A

synthetic androgen

-partial agonist at androgen receptor

29
Q

adverse danazol

A

hirsutism, acne, masculinization, weight gain, edema

30
Q

testosterone

A

agonist androgen receptors

31
Q

tx hypogonadism and promote secondary sex characters in boy

A

testosterone

32
Q

adverse testosterone

A

gonadal atrophy

premature closure epiphyseal plates- short stature

33
Q

finasteride

A

5a reductase inhibitor

-no peripheral T > DHT

34
Q

tx BPH and male pattern baldness

A

finasteride

35
Q

flutamide

A

nonsteroid competitive inhibitor at androgen receptors

tx prostate carcinoma

36
Q

ketoconazole

A

inhibit steroid synthesis

inhibit 17,20 desmolase

37
Q

spironolactone

A

inhibit steroid binding, 17a hydroxylase, and 17,20 desmolase

38
Q

tx of androgenic sx of PCOS

A

ketoconazole and spironolactone

39
Q

tamsulosin

A

a1 antagonist
-selective for a1-AD - in prostate

smooth muscle relaxation

40
Q

tx of BPH

A

tamsulosin

smooth muscle relax in prostate

41
Q

sildenafil

A

PDE5 inhibitor

42
Q

vardenafil

A

PDE5 inhibitor

43
Q

tadalafil

A

PDE5 inhibitor

44
Q

PDE5 inhibitor

A

increased cGMP, smooth m relaxation corpus cavernosum

increased blood flow - erection

45
Q

adverse PDE5 inhibitor

A

HA, flush, dyspepsia, cyanopsia (blue tint vision)

46
Q

life threatening hypotension

A

if give nitrate and PDE5 inhibitor together

47
Q

minoxidil

A

direct arteriolar vasodilator

tx of androgenetic alopecia and severe refractory HTN

Board Review - B - Systems Pharmacology (26 decks)

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