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Board Review - B - Systems Pharmacology > MSK II > Flashcards

MSK II Flashcards

1
Q

teriparatide

A

recombinant PTH analog

give subQ daily

increased osteoblast activity

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2
Q

clinical use teriparatide

A

osteoporosis

cause increased bone growth

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3
Q

teriparatide adverse

A

transient hyperCa

increased risk osteosarcoma possible

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4
Q

allopurinol

A

inhibit xanthine oxidase

decrease conversion xanthine > uric acid

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5
Q

prevention tumor lysis syndrome

A

allopurinol

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6
Q

febuxostat

A

inhibit xanthine oxidase

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7
Q

pegloticase

A

recombinant uricase

-catalyze metabolism uric acid > allantoin (water soluble)

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8
Q

probenecid

A

inhibit reabsorption uric acid proximal convoluted tubule

can precipitate uric acid calculi

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9
Q

adverse probenecid

A

precipitate uric acid calculi

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10
Q

chronic gout tx

A

prevention

allopurinol
febuxostat
pegloticase
probenecid

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11
Q

acute gout tx

A

NSAID
glucocorticoid
colchicine

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12
Q

colchicine

A

bind and stabilize tubulin

  • inhibit microtubule polymerization
  • impair neutrophil chemotaxis and degranulation
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13
Q

adverse colchicine

A

don’t give salicylates

all but highest doses depress uric acid clearance

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14
Q

TNF-a inhibitors

A

all predispose to infection

reactivate latent TB - TNF needed to stabilize granuloma

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15
Q

etanercept

A

TNF-a inhibitor

fusion protein
-receptor for TNF-a + IgG1 Fc

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16
Q

infliximab

A

anti-TNF-a monoclonal Ab

17
Q

adalimumab

A

anti-TNF-a monoclonal Ab

18
Q

tx rheumatoid arthritis, psoriasis, ankylosing spondylitis

A

etancercept

19
Q

tx IBD, rheumatoud arthritis, ankylosing spondylitis, psoriasis

A

infliximab

adaliumuab

Board Review - B - Systems Pharmacology (26 decks)

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