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Board Review - B - Systems Pharmacology > Psych II > Flashcards

Psych II Flashcards

1
Q

fluoxetine

A

SSRI

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2
Q

paroxetine

A

SSRI

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3
Q

sertraline

A

SSRI

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4
Q

citalopram

A

SSRI

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5
Q

SSRIs

A

5-HT specific reuptake inhibitors

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6
Q

clinical use SSRI

A 
depression
GAD
panic disorder
OCD
bulimia
social phobia
PTSD
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7
Q

SSRI time to take effect

A

4-8 weeks

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8
Q

serotonin syndrome

A

any drug increased 5-HT
-SNRI, MAOI, SSRI, TCA

hyperthermia, confusion, myoclonus, CV instability, flushing, diarrhea, seizures

tx - cyproheptadine

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9
Q

cyproheptadine

A

5-HT2 receptor antagonist

tx serotonin syndrome

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10
Q

venalfaxine

A

SNRI

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11
Q

duloxetine

A

SNRI

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12
Q

SNRI

A

inhibit 5-HT and NE reuptake

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13
Q

clinical use SNRI

A

depression

venlafaxine - GAD, panic disorder, PTSD
duloxetine - diabetic peripheral neuropathy

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14
Q

amitriptyline

A

TCA antidepressant

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15
Q

nortriptyline

A

TCA antidepressant

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16
Q

imipramine

A

TCA antidepressant

17
Q

desipramine

A

TCA antidepressant

18
Q

clomipramine

A

TCA antidepressant

19
Q

doxepin

A

TCA antidepressant

20
Q

amoxapine

A

TCA antidepressant

21
Q

TCA antidepressant

A

block reuptake of NE and 5-HT

22
Q

3rd vs. 2nd degree TCA

A

amitriptyline - 3rd
nortriptyline - 2nd

3rd - more anticholinergic effect - prolong QT interval

23
Q

Tri-Cs

A

adverse of TCA antidepressants

convulsions
coma
cardiotoxicity

24
Q

tx TCA toxicity

A

NaHCO3 - prevent arrhythmia

25
Q

tranylcypromine

A

monoamine oxidase inhibitor

26
Q

phenelzine

A

monoamine oxidase inhibitor

27
Q

isocarboxazid

A

monoamine oxidase inhibitor

28
Q

selegiline

A

monoamine oxidase inhibitor - selective MAO-B

29
Q

MAO inhibitors

A

nonselective MAO inhibition

  • increased level of amine NTs
  • NE, 5-HT, DA
30
Q

clinical use MAOIs

A

atypical depression

31
Q

ingestion of tyramine

A

wine and cheese - rich foods

toxicity with MAOIs
-get HTN crisis

32
Q

CI for MAOI use

A

use of SSRI, TCA, dextromethorphan

-prevent serotonin syndrome

33
Q

bupropion

A

atypical antidepressant

increase NE and DA - unknown mechanism

34
Q

smoking cessation

35
Q

no sexual side effects

36
Q

mirtazapine

A

atypical antidepressant
a2 agonist - increased release of NE and 5-HT
-potent 5-HT2 and 5-HT3 receptor antagonists

37
Q

trazadone

A

atypical antidepressant
block 5-HT2 and a1 receptors
-tx of insomnia

high dose - for antidepressant effect

38
Q

erection side effect

A

trazadone

trazaBONER

Board Review - B - Systems Pharmacology (26 decks)

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