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Board Review - B - Systems Pharmacology > Gastrointestinal I > Flashcards

Gastrointestinal I Flashcards

1
Q

cimetidine

A

H2 blocker

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2
Q

ranitidine

A

H2 blocker

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3
Q

famotidine

A

H2 blocker

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4
Q

nizatidine

A

H2 blocker

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5
Q

H2 blocker MOA

A

reversible inhibition histamine H2 receptor

decreased H+ secretion parietal cells

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6
Q

adverse cimetidine

A

inhibit CYP 450

antiandrogenic - PRL release, gynecomastia, impotence, decreased libido in males

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7
Q

cimetidine and ranitidine

A

decrease renal excretion of creatinine

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8
Q

omeprazole

A

PPI

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9
Q

lansoprazole

A

PPI

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10
Q

esomephazole

A

PPI

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11
Q

pantoprazole

A

PPI

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12
Q

dexlansoprazole

A

PPI

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13
Q

PPI MOA

A

irreversible inhibit H/K ATPase in stomach parietal cell

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14
Q

adverse PPI

A

increased risk C. dif infection, pneumonia

long term use - decreased magnesium

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15
Q

bismuth MOA

A

bind ulcer base - protect - allow bicarb secretion to reestablish pH

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16
Q

sucralafate MOA

A

bind ulcer base - protect - allow bicarb secretion to reestablish pH

17
Q

misoprostol

A

PGE1 analog

increased production and secretion of gastric mucous
decreased acid production

prevent NSAID induced PUD

18
Q

adverse misoprostol

A

abortifacient - CI in women childbearing potential

19
Q

octreotide

A

long acting somatostatin analog
-inhibit vasoconstriction by splanchnic hormones

tx of variceal bleeds

20
Q

aluminum hydroxide

A

antacid

overuse - constipation

21
Q

calcium carbonate

A

antacid

overuse - chelate other drugs

22
Q

magnesium hydroxide

A

antacid

overuse - diarrhea, hyporeflex, hypotension, cardiac arrest

23
Q

adverse of antacids

A

affect absorption, bioavailability, urinary excretion of other drugs

also - hypoK

24
Q

magnesium hydroxide

A

also osmotic laxative

draw water into lumen

25
magnesium citrate
osmotic laxative
26
polyethylene glycol
osomtic laxative
27
lactulose
osmotic laxative
28
sulfasalazine
combo sulfapyridine and 5-aminosalicylic acid sulfapyridine - antibacterial 5-aminosalicyclic acid - anti-inflammatory activated by colon bacteria tx UC and crohns
29
adverse sulfasalazine
malaiase, nausea, sulfonamide toxicity, reversible oligospermia
30
ondansetron
5-HT3 antagonist -decreased vagal stimulation central acting antiemetic
31
chemo nausea tx
ondansetron
32
adverse ondansetron
HA, constipation, QT interval prolongation
33
metoclopramide
D2 antagonist | -antiemetic
34
adverse metoclopramide
parkinsonian effects tardive dyskinesia CI - small bowel obstruction - due to D1 receptor blockade
35
orlistat
inhibit gastric and pancreatic lipase decreased breakdown and absorption of dietary fat used as weight loss drug
36
adverse orlistat
steatorrhea decreased absorption fat soluble vitamins

Board Review - B - Systems Pharmacology (26 decks)

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