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Board Review - B - Systems Pharmacology > Gastrointestinal I > Flashcards

Gastrointestinal I Flashcards

1
Q

cimetidine

A

H2 blocker

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2
Q

ranitidine

A

H2 blocker

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3
Q

famotidine

A

H2 blocker

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4
Q

nizatidine

A

H2 blocker

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5
Q

H2 blocker MOA

A

reversible inhibition histamine H2 receptor

decreased H+ secretion parietal cells

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6
Q

adverse cimetidine

A

inhibit CYP 450

antiandrogenic - PRL release, gynecomastia, impotence, decreased libido in males

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7
Q

cimetidine and ranitidine

A

decrease renal excretion of creatinine

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8
Q

omeprazole

A

PPI

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9
Q

lansoprazole

A

PPI

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10
Q

esomephazole

A

PPI

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11
Q

pantoprazole

A

PPI

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12
Q

dexlansoprazole

A

PPI

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13
Q

PPI MOA

A

irreversible inhibit H/K ATPase in stomach parietal cell

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14
Q

adverse PPI

A

increased risk C. dif infection, pneumonia

long term use - decreased magnesium

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15
Q

bismuth MOA

A

bind ulcer base - protect - allow bicarb secretion to reestablish pH

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16
Q

sucralafate MOA

A

bind ulcer base - protect - allow bicarb secretion to reestablish pH

17
Q

misoprostol

A

PGE1 analog

increased production and secretion of gastric mucous
decreased acid production

prevent NSAID induced PUD

18
Q

adverse misoprostol

A

abortifacient - CI in women childbearing potential

19
Q

octreotide

A

long acting somatostatin analog
-inhibit vasoconstriction by splanchnic hormones

tx of variceal bleeds

20
Q

aluminum hydroxide

A

antacid

overuse - constipation

21
Q

calcium carbonate

A

antacid

overuse - chelate other drugs

22
Q

magnesium hydroxide

A

antacid

overuse - diarrhea, hyporeflex, hypotension, cardiac arrest

23
Q

adverse of antacids

A

affect absorption, bioavailability, urinary excretion of other drugs

also - hypoK

24
Q

magnesium hydroxide

A

also osmotic laxative

draw water into lumen

25
Q

magnesium citrate

A

osmotic laxative

26
Q

polyethylene glycol

A

osomtic laxative

27
Q

lactulose

A

osmotic laxative

28
Q

sulfasalazine

A

combo sulfapyridine and 5-aminosalicylic acid

sulfapyridine - antibacterial
5-aminosalicyclic acid - anti-inflammatory

activated by colon bacteria

tx UC and crohns

29
Q

adverse sulfasalazine

A

malaiase, nausea, sulfonamide toxicity, reversible oligospermia

30
Q

ondansetron

A

5-HT3 antagonist
-decreased vagal stimulation

central acting antiemetic

31
Q

chemo nausea tx

A

ondansetron

32
Q

adverse ondansetron

A

HA, constipation, QT interval prolongation

33
Q

metoclopramide

A

D2 antagonist

-antiemetic

34
Q

adverse metoclopramide

A

parkinsonian effects
tardive dyskinesia

CI - small bowel obstruction - due to D1 receptor blockade

35
Q

orlistat

A

inhibit gastric and pancreatic lipase

decreased breakdown and absorption of dietary fat

used as weight loss drug

36
Q

adverse orlistat

A

steatorrhea

decreased absorption fat soluble vitamins

Board Review - B - Systems Pharmacology (26 decks)

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