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Board Review - B - Systems Pharmacology > Antimicrobials VII > Flashcards

Antimicrobials VII Flashcards

1
Q

abacavir

A

NRTI

ABC

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2
Q

didanosine

A

NRTI

ddl

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3
Q

emtricitabine

A

NRTI

FTC

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4
Q

lamivudine

A

NRTI

3TC

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5
Q

stavudine

A

NRTI

d4T

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6
Q

tenofovir

A

NRTI

TDF

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7
Q

zidovudine

A

NRTI

ZDV

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8
Q

NRTIs

A

competitive inhibition of nucleotide binding to reverse transcriptase

termination DNA chain

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9
Q

tenofovir

A

nucleotide - does not need to be phosphorylate

all other NRTIs - need to be phosphorylated

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10
Q

prophylaxis of HIV positive pregnant woman to prevent fetal transmission

A

zidovudine

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11
Q

adverse NRTI

A

bone marrow suppression

reversed with G-CSF and EPO

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12
Q

delaviridine

A

NNRTI

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13
Q

efavirenz

A

NNRTI

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14
Q

nevirapine

A

NNRTI

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15
Q

NNRTIs

A

bind reverse transcriptase site different than NRTI

don’t require phosphorylation

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16
Q

CI in pregnancy

A

delaviridine and efavirenz

NNRTIs

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17
Q

enfuvirtide

A

bind gp41 - inhibit HIV viral entry

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18
Q

maraviroc

A

bind CCR-5 on T cell/monocyte

inhibit interaction with gp120

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19
Q

interferon

A

glycoprotein - normally synthesized - viral infected cells

-antiviral and antitumor properties

20
Q

IFN-a

A

tx hep B and C, kaposi sarcoma, hary cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

21
Q

IFN-B

A

tx multiple sclerosis

22
Q

IFN-gamma

A

tx chronic granulomatous disease

23
Q

adverse IFN

A

neutropenia, myopathy

24
Q

ribavirin

A

inhibit synthesis guanine nucleotides

-competitive inhibit inosine monophosphate DH

25
Q

simeprevir

A

HCV protease inhibitor - prevent viral replication

26
Q

sofobuvir

A

inhibit HCV RNA dependent RNA polymerase

-chain terminator

27
Q

tx chronic HSV

A

ribavarin

combo with simeprevir and sofosbuvir

28
Q

adverse ribavirin

A

hemolytic anemia

teratogen

29
Q

adverse simeprevir

A

photosensitive rxn, rash

30
Q

adverse sofosbuvir

A

fatigue, HA, nausea

31
Q

autoclave

A

pressure steam at 120C

-may be sporicidal

32
Q

alcohol

A

denature protein and disrupt cell membrane

not sporicidal

33
Q

chlorhexidine

A

denature protein and disrupt cell membrane

not sporicidal

34
Q

hydrogen peroxide

A

denature protein and disrupt cell membrane

sporicidal

35
Q

iodine and iodophors

A

halogenation of DNA, RNA, proteins

may be sporicidal

36
Q

disinfection

A

organism number to safe level

37
Q

sterilization

A

inactivate self propagate biologic entities

38
Q

sulfonamides in pregnancy

A

kernicterus

39
Q

aminoglycoside in pregnancy

A

ototoxicity

40
Q

fluoroquinolone in pregnancy

A

cartilage damage

41
Q

clarithromycin in pregnancy

A

embryotoxic

42
Q

tetracycline in pregnancy

A

discolored teeth

inhibit bone growth

43
Q

ribavirin in pregnancy

44
Q

griseofulvin in pregnancy

45
Q

chloramphenicol in pregnancy

A

gray baby syndrome

Board Review - B - Systems Pharmacology (26 decks)

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