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Board Review - B - Systems Pharmacology > Psych I > Flashcards

Psych I Flashcards

1
Q

tx ADHD

A

stimulants - methylphenidate

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2
Q

tx alcohol withdrawal

A

long acting benzo

-chlordiazepam, lorazepam, diazepam

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3
Q

tx bipolar

A

lithium
valproic acid
atypical antipsychotics

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4
Q

tx bulimia

A

SSRI

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5
Q

tx depression

A

SSRI

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6
Q

tx GAD

A

SSRI

SNRI

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7
Q

tx OCD

A

SSRI

clomipramine

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8
Q

tx panic disorder

A

SSRI
venlafaxine
benzos

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9
Q

tx PTSD

A

SSRI

venlafaxine

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10
Q

tx schizophrenia

A

atypical antipsychotics

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11
Q

tx social phobia

A

SSRI

beta-blockers

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12
Q

tx tourette

A

antipsychotic
tetrabenazine
clonidine

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13
Q

methylphenidate

A

CNS stimulant - increased catecholamine at synaptic cleft

NE and DA

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14
Q

dextroamphetamine

A

CNS stimulant - increased catecholamine at synaptic cleft

NE and DA

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15
Q

methamphetamine

A

CNS stimulant - increased catecholamine at synaptic cleft

NE and DA

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16
Q

typical antipsychotics

A

neuroleptics

all block dopamine D2 receptors - increased cAMP

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17
Q

haloperidol

A

typical antipsychotic

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18
Q

trifluoperazine

A

typical antipsychotic

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19
Q

fluphenazine

A

typical antipsychotic

20
Q

thioridiazine

A

typical antipsychotic

21
Q

chlorpromazine

A

typical antipsychotic

22
Q

high potency typical antipsychotic

A

trifluoperazine
fluphenazine
haloperidol

neuro side effects - huntington, extrapyramidal

23
Q

low potency typical antipsychotic

A

chlorpromazine
thioridazine

non - neuro side effects - anticholinergic, antihistmaine, a1 block

24
Q

adverse chlorpromazine

A

corneal deposits

25
Q

adverse thioridazine

A

retinal deposits

26
Q

adverse haloperidol

A

NMS

tardive dyskinesia

27
Q

endocrine defect with typical antipsychotics

A

dopamine receptor antagonist

  • hyperPRL
  • galactorrhea
28
Q

neuroleptic malignant syndrome

A

rigid, myoglobinuria, autonomic instable, hyperpyrexia
-with typical antipsychotic use

tx - dantrolene or bromocriptine (D2 agonist)

29
Q

olanzapine

A

atypical psychotic

30
Q

clozapine

A

atypical psychotic

31
Q

quetiapine

A

atypical psychotic

32
Q

risperidone

A

atypical psychotic

33
Q

aripiprazole

A

atypical psychotic

34
Q

ziprasidone

A

atypical psychotic

35
Q

atypical psychotic MOA

A

not completely understood

variable effect - 5HT2, DA, alpha and H1 receptors

36
Q

schizophrenia tx

A

positive sx - typical antipsychotic

positive and negative sx - atypical antipsychotic

37
Q

tardive dyskinesia

A

with long term antipsychotic use

oral-facial movements

38
Q

adverse clozapine

A

weight gain
agranulocytosis
seizure

39
Q

risperidone adverse

A

increased PRL - lactation and gynecomastia

40
Q

lithium

A

mood stabilizer for bipolar

block relapse and acute manic events

41
Q

adverse lithium

A

tremor
hypothyroid
polyuria - nephrogenic DI
teratogenesis

ebstein anomaly in newborn - pregnant mother use

42
Q

ebstein anomaly

A

congenital heart defect

  • septal and posterior leaflets of tricupsid valve
  • displaced toward apex right ventricle
43
Q

narrow therapeutic window

A

lithium

44
Q

lithium pharmacodynamics

A

narrow therapy window
-close serum monitoring

excreted by kidneys - reabsorbed at PCT with Na

45
Q

tx lithium toxicity

A

thiazide diuretic

46
Q

buspirone

A

stimulate 5-HT1A receptors

tx GAD

takes 1-2 weeks to take effect

47
Q

takes 1-2 weeks to get clinical effect

A

buspirone for tx of GAD

Board Review - B - Systems Pharmacology (26 decks)

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