Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Board Review - B - Systems Pharmacology > Antimicrobials V > Flashcards

Antimicrobials V Flashcards

1
Q

nystatin

A

bind ergosterol - form pores

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

nystatin clinical use

A

topical only - too toxic for systemic

diaper rash or vaginal candidiasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

oral candidiasis

A

swish and swallow nystatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

flucytosine

A

inhibit DNA and RNA biosynthesis

-convert to 5-FU by cytosine deaminase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

adverse flucytosine

A

bone marrow suppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

clinical use flucytosine

A

crypto meningitis

-in combo with amphotericin B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

clotrimazole

A

azole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

fluconazole

A

azole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

itraconazole

A

azole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ketoconazole

A

azole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

miconazole

A

azole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

voriconazole

A

azole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

azole

A

inhibit fungal sterol (ergosterol) synthesis

inhibit P450 enzyme that converts lanosterol > ergosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

other tx for blastomyces

A

itraconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

other tx of coccidioides

A

itraconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

other tx of histoplasma

A

itraconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

chronic suppression of cryptococcal meningitis in AIDS patients

A

fluconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

topical fungal infection tx

A

clotrimazole

miconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

adverse azole

A

testosterone synthesis inhibition - gynecomastia

liver dysfxn - inhibit P450

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

terbinafine

A

inhibit fungal enzyme squalene epoxidase

stop conversion squalene > squalene epoxide
-precursor in synthesis of ergosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

tx of onychomycosis

A

fungal infection under finger/toe nails

terbinafine

22
Q

adverse terbinafine

A

GI upset
HA
hepatotoxic
taste disturbance

23
Q

anidulafungin

A

echinocandin

24
Q

caspofugin

A

echinocandin

25
Q

micafungin

A

echinocandin

26
Q

echinocandin

A

inhibit cell wal lsynthesisi - inhibit synthesis of beta-glucan

27
Q

ergosterol

A

in cell MEMBRANE

amphotericin B and nystatin poke hole

28
Q

cell wall of fungi

A

inhibited by echinocandin

-caspofungin, micafungin, anidulafungin

29
Q

griseofulvin

A

interfere microtubule fxn
-disrupt mitosis

deposit in keratin containing tissues

30
Q

ora tx for dermatophytes

A

griseofulvin

tinea, ringworm, etc.

31
Q

tx toxoplasmosis

A

pyrimethamine

32
Q

tx trypanosoma brucei

A

suramin

melarsoprol

33
Q

tx t. cruzi

A

nifurtimox

34
Q

tx leishmaniasis

A

sodium stibogluconate

35
Q

permethrin

A

block Na channel - neurotoxic

36
Q

malathion

A

acetylcholinesterae inhibitor

37
Q

lindane

A

inhibit GABA - neurotoxic

38
Q

tx for scabies

A

permerthrin
malathion
lindane

39
Q

lice

A

pediculus
pthirus

tx - permethrin, malathion, lindane

40
Q

chloroquine

A

block detoxification of heme into hemozoin

-heme accumulate - toxic to plasmodia

41
Q

tx of plasmodium infections

A

chloroquine

42
Q

adverse chloroquine

A

retinopathy

pruritis - dark skinned individuals

43
Q

plasmodium falciprum

A

high resistance

-so tx with chloroquine doesn’t work

44
Q

resistance to chloroquine

A

membrane pump - decrease intracellular concentration of drug

45
Q

tx of p. falciprum

A

artemether/lumefantrine

atovaquone/proguanil

46
Q

tx life-threatening malaria

A

quinidine or artesunate

47
Q

mebendazole

A

anti-helminth tx

48
Q

pyrantel pamoate

A

anti-helminth tx

49
Q

ivermectin

A

anti-helminth tx

50
Q

diethylcarbamazine

A

anti-helminth tx

51
Q

praziquantel

A

anti-helminth tx

Board Review - B - Systems Pharmacology (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions