Heme/Oncology III

Question 1

prednisone

Answer 1

bind intracytoplasmic - alter gene expression

MC glucocorticoid in cancer chemotherapy

Question 2

adverse prednisone

Answer 2

cushing like syndrome

-weight gain, central obesity, muscle breakdown, cataract, acne, osteoporosis, HTN

Question 3

bevacizumab

Answer 3

monoclonal Ab - VEGF

inhibit angiogenesis

Question 4

erlotinib

Answer 4

EGFR tyrosine kinase inhibitor

tx - non small cell lung ca

adverse - rash

Question 5

adverse bevacizumab

Answer 5

hemorrhage

VEGF mAb

Question 6

imatinib

Answer 6

tyrosine kinase BCR-ABL inhibitor and c-kit inhibitor

Question 7

clinical imatinib

Answer 7

CML - BCR-ABL
GI stromal tumor - c-kit

tyrosine kinase inhibitor

Question 8

rituximab

Answer 8

monoclonal Ab - CD20 - B cell neoplasms

Question 9

adverse rituximab

Answer 9

progressive multifocal leukencephalopathy

Question 10

tamoxifen

Answer 10

selective estrogen receptor modulator - SERM

Question 11

raloxifene

Answer 11

selective estrogen receptor modulator - SERM

Question 12

SERM

Answer 12

selective estrogen receptor modulator

antagonist breast
agonist bone

Question 13

tx breast cancer and prevent osteoporosis

Answer 13

tamoxifen

Question 14

tamoxifen adverse

Answer 14

agonist endometrium - increased risk endometrial caner

Question 15

raloxifene adverse

Answer 15

no increase in endometrial carcinoma

is estrogen receptor antagonist

Question 16

trastuzumab

Answer 16

monoclonal Ab - Her-2 - tyrosine kinase receptor

tx of Her-2 positive breast cancer and gastric cancer

Question 17

adverse trastuzumab

Answer 17

cardiotoxicity

Question 18

vemurafenib

Answer 18

small molecule inhibitor BRAF oncogene

tx of melanoma

Question 19

tx metastatic melanoma

Answer 19

vemurafenib

Question 20

acoustic nerve damage

Answer 20

cisplatin

carboplatin

Question 21

peripheral neuropathy

Answer 21

vincristine

Question 22

pulmonary fibrosis

Answer 22

bleomycin

busulfan

Question 23

cardiotoxicity

Answer 23

doxorubicin

trastuzumab

Question 24

nephrotoxic

Answer 24

cisplatin

carboplatin

Question 25

hemorrhagic cystitis

Answer 25

cyclophosphamide

Question 26

myelosuppression

Answer 26

5-FU 6-MP methotrexate

Question 27

cell phase bleomycin

Answer 27

G2

Question 28

cell phase paclitaxel

Answer 28

M

Question 29

cell phase vinblastine

Answer 29

M

Question 30

cell phase vincristine

Answer 30

M

Question 31

cell phase cisplastin

Answer 31

G1

Question 32

cell phase 5-FU

Answer 32

S

Question 33

cell phase 6-MP

Answer 33

S

Question 34

cell phase MTX

Answer 34

S

Question 35

cell phase hydroxyurea

Answer 35

S