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Board Review - B - Systems Pharmacology > Heme/Oncology III > Flashcards

Heme/Oncology III Flashcards

1
Q

prednisone

A

bind intracytoplasmic - alter gene expression

MC glucocorticoid in cancer chemotherapy

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2
Q

adverse prednisone

A

cushing like syndrome

-weight gain, central obesity, muscle breakdown, cataract, acne, osteoporosis, HTN

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3
Q

bevacizumab

A

monoclonal Ab - VEGF

inhibit angiogenesis

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4
Q

erlotinib

A

EGFR tyrosine kinase inhibitor

tx - non small cell lung ca

adverse - rash

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5
Q

adverse bevacizumab

A

hemorrhage

VEGF mAb

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6
Q

imatinib

A

tyrosine kinase BCR-ABL inhibitor and c-kit inhibitor

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7
Q

clinical imatinib

A

CML - BCR-ABL
GI stromal tumor - c-kit

tyrosine kinase inhibitor

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8
Q

rituximab

A

monoclonal Ab - CD20 - B cell neoplasms

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9
Q

adverse rituximab

A

progressive multifocal leukencephalopathy

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10
Q

tamoxifen

A

selective estrogen receptor modulator - SERM

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11
Q

raloxifene

A

selective estrogen receptor modulator - SERM

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12
Q

SERM

A

selective estrogen receptor modulator

antagonist breast
agonist bone

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13
Q

tx breast cancer and prevent osteoporosis

A

tamoxifen

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14
Q

tamoxifen adverse

A

agonist endometrium - increased risk endometrial caner

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15
Q

raloxifene adverse

A

no increase in endometrial carcinoma

is estrogen receptor antagonist

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16
Q

trastuzumab

A

monoclonal Ab - Her-2 - tyrosine kinase receptor

tx of Her-2 positive breast cancer and gastric cancer

17
Q

adverse trastuzumab

A

cardiotoxicity

18
Q

vemurafenib

A

small molecule inhibitor BRAF oncogene

tx of melanoma

19
Q

tx metastatic melanoma

A

vemurafenib

20
Q

acoustic nerve damage

A

cisplatin

carboplatin

21
Q

peripheral neuropathy

A

vincristine

22
Q

pulmonary fibrosis

A

bleomycin

busulfan

23
Q

cardiotoxicity

A

doxorubicin

trastuzumab

24
Q

nephrotoxic

A

cisplatin

carboplatin

25
Q

hemorrhagic cystitis

A

cyclophosphamide

26
Q

myelosuppression

A

5-FU
6-MP
methotrexate

27
Q

cell phase bleomycin

A

G2

28
Q

cell phase paclitaxel

A

M

29
Q

cell phase vinblastine

A

M

30
Q

cell phase vincristine

A

M

31
Q

cell phase cisplastin

A

G1

32
Q

cell phase 5-FU

A

S

33
Q

cell phase 6-MP

A

S

34
Q

cell phase MTX

A

S

35
Q

cell phase hydroxyurea

A

S

Board Review - B - Systems Pharmacology (26 decks)

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