Neuro III Flashcards by Matt Stanton

Q

succinylcholine

A

depolarizing agent

strong ACh agonist - resistance acetylcholinesterase

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Q

succinylcholine blockade phases

A

phase 1- prolonged depolarization - no antidote

phase 2 - repolarized but blocked - ACh receptor available but desensitized - antidote - cholinesterase inhibitor

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Q

adverse succinylcholine

A

hyperCa
hyperK
malignant hyperthermia

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Q

tubocurarine

A

nondepolarizing muscular blockage

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Q

atracurium

A

nondepolarizing muscular blockage

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Q

pancuronium

A

nondepolarizing muscular blockage

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Q

vecuronium

A

nondepolarizing muscular blockage

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Q

rocuronium

A

nondepolarizing muscular blockage

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Q

nondepolarizing muscular blockage

A

competitive antagonist - compete for ACh at receptors

reversal - neostigmine - with atropine - to prevent muscarinic effects - bradycardia

also - edrophonium and other cholinesterase inhibitor

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Q

dantrolene

A

prevent release Ca from SR of skeletal m

tx of malignant hyperthermia and neuroleptic malignant syndrome

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Q

baclofen

A

inhibit GABA-B - at spinal cord

skeletal m relaxation

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Q

cyclobenzaprine

A

central acting skeletal m relaxant

tx muscle spasms

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Q

bromocriptine

A

ergot dopamine agonist

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Q

pramipexole

A

non-ergot dopamine agonist

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Q

ropinirole

A

non-ergot dopamine agonist

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Q

amantadine

A

increase dopamine availability

increased DA release
decreased DA uptake

antiviral - influenza A and rubella

Q

adverse amantadine

A

livedo reticularis

Q

carbidopa

A

decreased peripheral conversion L-dopa

inhibit DOPA decarboxylase

Q

entacapone

A

prevent peripheral L-dopa metabolism

inhibit COMT

Q

tolcapone

A

prevent peripheral L-dopa metabolism

inhibit COMT

Q

selegiline

A

block conversion DA > 3MT
-inhibit MAO-B

MAO-B in nerve terminal - metabolize dopamine over NE and 5-HT - so inhibit - more DA available

Q

benztropine

A

anti-muscarinic

tx tremor and rigidity of parkinsons

little effect bradykinesia

Q

tolcapone

A

inhibit COMT - peripheral AND centrally

Q

memantine

A

NMDA receptor antagonist

tx of alzheimers

helps prevent excitotoxicity

donepezil

AChE inhibitor tx of alzheimers

galantamine

AChE inhibitor tx of alzheimers

rivastigmine

AChE inhibitor tx of alzheimers

tacrine

AChE inhibitor tx of alzheimers

huntington disease NT changes

decreased GABA decreased ACh increased DA

tetrabenazine

inhibit vesicular monoamine transport - limit dopamine vesicle pack and release tx of huntington

reserpine

inhibit vesicular monoamine transport - limit dopamine vesicle pack and release tx of huntington

haloperidol

D2 receptor antagonist tx of huntington

triptans

5-HT 1B/1D agonist inhibit trigeminal n activation prevent vasoactive peptide release induce vasoconstriction

tx migraine

sumatriptan

tx cluster HAs

sumatriptan

adverse triptans

coronary vasospasm | -CI prinzmetal angina