Neuro III Flashcards by Matt Stanton | Brainscape

Q

succinylcholine

A

depolarizing agent

strong ACh agonist - resistance acetylcholinesterase

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Q

succinylcholine blockade phases

A

phase 1- prolonged depolarization - no antidote

phase 2 - repolarized but blocked - ACh receptor available but desensitized - antidote - cholinesterase inhibitor

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Q

adverse succinylcholine

A

hyperCa
hyperK
malignant hyperthermia

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Q

tubocurarine

A

nondepolarizing muscular blockage

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Q

atracurium

A

nondepolarizing muscular blockage

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Q

pancuronium

A

nondepolarizing muscular blockage

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Q

vecuronium

A

nondepolarizing muscular blockage

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Q

rocuronium

A

nondepolarizing muscular blockage

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Q

nondepolarizing muscular blockage

A

competitive antagonist - compete for ACh at receptors

reversal - neostigmine - with atropine - to prevent muscarinic effects - bradycardia

also - edrophonium and other cholinesterase inhibitor

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Q

dantrolene

A

prevent release Ca from SR of skeletal m

tx of malignant hyperthermia and neuroleptic malignant syndrome

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Q

baclofen

A

inhibit GABA-B - at spinal cord

skeletal m relaxation

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Q

cyclobenzaprine

A

central acting skeletal m relaxant

tx muscle spasms

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Q

bromocriptine

A

ergot dopamine agonist

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Q

pramipexole

A

non-ergot dopamine agonist

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Q

ropinirole

A

non-ergot dopamine agonist

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Q

amantadine

A

increase dopamine availability

increased DA release
decreased DA uptake

antiviral - influenza A and rubella

Q

adverse amantadine

A

livedo reticularis

Q

carbidopa

A

decreased peripheral conversion L-dopa

inhibit DOPA decarboxylase

Q

entacapone

A

prevent peripheral L-dopa metabolism

inhibit COMT

Q

tolcapone

A

prevent peripheral L-dopa metabolism

inhibit COMT

Q

selegiline

A

block conversion DA > 3MT
-inhibit MAO-B

MAO-B in nerve terminal - metabolize dopamine over NE and 5-HT - so inhibit - more DA available

Q

benztropine

A

anti-muscarinic

tx tremor and rigidity of parkinsons

little effect bradykinesia

Q

tolcapone

A

inhibit COMT - peripheral AND centrally

Q

memantine

A

NMDA receptor antagonist

tx of alzheimers

helps prevent excitotoxicity

Q

donepezil

A

AChE inhibitor

tx of alzheimers

Q

galantamine

A

AChE inhibitor

tx of alzheimers

Q

rivastigmine

A

AChE inhibitor

tx of alzheimers

Q

tacrine

A

AChE inhibitor

tx of alzheimers

Q

huntington disease NT changes

A

decreased GABA
decreased ACh
increased DA

Q

tetrabenazine

A

inhibit vesicular monoamine transport - limit dopamine vesicle pack and release

tx of huntington

Q

reserpine

A

inhibit vesicular monoamine transport - limit dopamine vesicle pack and release

tx of huntington

Q

haloperidol

A

D2 receptor antagonist

tx of huntington

Q

triptans

A

5-HT 1B/1D agonist

inhibit trigeminal n activation

prevent vasoactive peptide release

induce vasoconstriction

Q

tx migraine

A

sumatriptan

Q

tx cluster HAs

A

sumatriptan

Q

adverse triptans

A

coronary vasospasm

-CI prinzmetal angina