Regulation of stroke volume & heart rate Flashcards
what are the effects of the sympathetic system on heart rate
the sympathetic nervous system releases the hormones to accelerate the heart rate
what are the effects of the parasympathetic system on heart rate
stimulating the parasympathetic nervous system increases the resting potential and decreases the rate of diastolic depolarisation; under these circumstances the heart rate slows
what is the effect of the sympathetic system on stroke volume
stroke volume increases,
heart rate and contractility also increases
what activates the sympathetic nervous system
exercise
what are the effects of preload on stroke volume
increase in stroke volume
what are the effects of after load on stroke volume
increasing after-load reduces stroke volume
what is after-load
it is the stress in the wall of the left ventricle during ejection, i.e. it is the end load against which the heart contracts to eject blood
what are the components after-load is broken into
one factor is the aortic pressure the left ventricular muscle must overcome to eject blood
what are factors that affect after-load
age
increased blood pressure
hypertension
constriction of the arteries
what else does increasing after-load effect, apart from reducing stroke volume
increasing after-load also increases left ventricular end-diastolic pressure
what does preload refer to
the end diastolic volume that stretches the right or left ventricle of the heart to its greatest dimensions under variable physiologic demand
what does after load to
it is the end load against which the heart contracts to eject blood
after load is readily broken into components, describe one factor
it is the aortic pressure the left ventricular muscle must overcome to eject blood
what forms the atrioventricular node
pacemaker cells
where is the atrioventricular node
the area between the ventricles
describe how sympathetic nerves control heart rate
sympathetic nerves release noradrenaline, which acts on beta receptors on the sinoatrial node, which increases pacemaker potential - leading to tachycardia - an increased heart rate
how do sympathetic nerves control heart rate
sympathetic nerves increase heart rate
describe parasympathetic and sympathetic activity whilst you are doing exercise
parasympathetic activity decreases
sympathetic activity increases
describe parasympathetic and sympathetic activity at rest
parasympathetic and sympathetic nerves always have ongoing activity at rest
where are beta 1 receptors present
on the sinoatrial node
describe how parasympathetic nerves control heart rate
parasympathetic nerves hyperpolarise the cells in the sinoatrial node
- resulting in it taking longer for the pacemaker potential to reach threshold
- making the interval between each heart beat longer
- resulting in bradycardia
- the heart rate is slowing down
how does the parasympathetic nerves control heart rate
parasympathetic nerves act to decrease heart rate
what does acetylcholine bind to
muscarinic receptors
what is the vagus
each of the 10 pairs of cranial nerves
what does the vagus supply
the heart, lungs, upper digestive tract, and other organs of the chest and abdomen
what do the 10 pairs of cranial nerves release
acetylcholine
describe how the vagus controls heart rate
- the vagus releases acetylcholine
- acetylcholine acts on muscarinic receptors on the sinoatrial node
- the pacemaker cells in the sinoatrial node hyper-polarise
- the slope of the pacemaker potential decreases
- resulting in the heart rate decreases
= bradycardia
how does the vagus control heart rate
the vagus decreases the heart rate
activity of the 10 pairs of cranial nerves = bradycardia
describe starling’s law
the energy of contraction is proportional to the initial length of the cardiac muscle fibre
how is tension formed
by the myosin cross bridges
what is the result of more cross bridges
the stronger contraction you can produce
what is the result of a shorter acting muscle length
the actin filaments start interfering with one another,
therefore there is not as good cross bridge formation,
therefore there is a weaker strength of contraction
in cardiac muscle what does stretching of a muscle fibre depend on
the end diastolic volume - how much blood is in the ventricle at the end of the filling phase
describe the ventricle filling phase and contraction relationship
the more blood you have squeezed into the ventricle during the filling phase will stretch that muscle more, therefore the more contraction you are going to get
describe preload
the amount of stretch put on a muscle before it starts to contract