Deep vein thrombosis & pulmonary thromboembolism Flashcards

1
Q

what is deep vein thrombosis

A

it is thrombosis in a vein lying deep below the skin, especially in the legs

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2
Q

when does deep vein thrombosis occur

A

when a thrombus forms in one or more of the deep veins in your body, usually in your legs

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3
Q

what can deep vein thrombosis cause

A

leg pain or swelling, but can also occur with no symptoms

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4
Q

what can sometimes occur for no apparent reason

A

DVT

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5
Q

list things that increase getting DVT

A
inactivity
staying in hospital
blood vessel damage
medical conditions
genetic conditions
pregnancy
contraceptive pills
hormone replacement therapy
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6
Q

state a medical condition that can cause DVT

A

vasculitis, varicose veins

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7
Q

state conditions that increase your risk of getting DVT

A
cancer
heart disease
infectious conditions
inflammatory conditions
thrombophilia
anti-phospholipid syndrome
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8
Q

how can cancer increase your chance of getting DVT

A

cancer treatments such as chemotherapy and radiotherapy can increase your risk of getting DVT

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9
Q

state a genetic condition that increases your risk of getting DVT

A

thrombophilia, it is a genetic condition where your blood has an increased tendency to clot

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10
Q

state an immune system disorder that increases your risk of getting DVT

A

anti-phospholipid syndrome, this disorder causes an increased risk of blood clots

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11
Q

state other causes of DVT

A
being overweight
being obese
smoking
dehydration
being over 60
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12
Q

what is the treatment of DVT

A

medicines called anticoagulants, these drugs prevent blood clot getting bigger and can prevent an embolism

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13
Q

what are anticoagulants referred to as

A

blood thinning medicines, however, they do not thin blood, they prevent clots forming so easily

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14
Q

state 2 anticoagulants used to treat DVT

A

heparin

warfarin

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15
Q

describe heparin treatment of DVT

A

heparin works immediately to prevent further clotting, it is injected straight into one of your veins generally

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16
Q

what are the 2 forms of heparin available

A

standard heparin

low molecular weight heparin

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17
Q

what are side effects of heparin

A

skin rash
bleeding
allergic reactions
weakening of the bones

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18
Q

describe warfarin treatment of DVT

A

warfarin is taken as a tablet, it prevents further blood clots occurring

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19
Q

what are 2 main complications of deep vein thrombosis

A

pulmonary embolism

post-thrombotic syndrome

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20
Q

what is the most serious complication of DVT

A

pulmonary embolism

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21
Q

When does pulmonary embolism occur as a complication of DVT

A

it happens when a piece of blood clot breaks off and travels through your bloodstream to your lungs, where it blocks one of the blood vessels

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22
Q

what is post-thrombotic syndrome

A

it is the occurrence of long term symptoms after having a DVT

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23
Q

what percentage of people with history of DVT does post-thrombotic syndrome affect?

A

20-40%

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24
Q

what do the symptoms of post-thrombotic syndrome include

A

calf pain
swelling
a rash
ulcers on the calf

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25
Q

what increases your risk of getting post-thrombotic syndrome

A

if your DVT is in your thigh vein
if you are overweight
if you have more than one DVT in the same leg

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26
Q

what is the initial investigation of choice in nearly all patients with suspected DVT

A

duplex ultrasound

27
Q

state 4 investigations of DVT

A

ultrasound
venography
CT venography
MRI

28
Q

what is pulmonary thromboembolism

A

it is a blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream

29
Q

what does pulmonary thromboembolism result from

A

usually thrombus in the leg that travels to the lung

30
Q

what is the presentation of pulmonary thromboembolism

A
chest pain
pain of the upper back
difficulty breathing
coughing up of blood
a developing DVT
31
Q

describe the management of pulmonary thromboembolism

A

injection of anticoagulant medicine in hospital,

anticoagulant tablets then for 3 months

32
Q

what is the role of anticoagulants

A

they stop blood clots getting bigger and prevent new clots forming

33
Q

state investigations of pulmonary thromboembolism

A
routine laboratory blood tests
chest x-rays
ECGs
ventilation/perfusion scan
CT pulmonary angiogram
pulmonary angiography
ECHO
MRI
compression ultrasound scan
34
Q

what is a thrombus

A

a blood clot formed in situ within the vascular system of the body and impedes blood flow

35
Q

what is a blood clot

A

blood that has been converted from a liquid state to a solid state

36
Q

what is a blood clot also called

A

a thrombus

37
Q

where is a blood clot

A

it is stationary within a vessel or the heart

38
Q

what is coagulation

A

the process by which a blood clot forms

39
Q

what is a clot made up of

A

fibrin
platelets
red blood cells

40
Q

what is arterial thrombosis

A

a blood clot in an artery

41
Q

what is the result of arterial thrombosis

A

it can be very serious and can stop blood reaching important organs

42
Q

what is venous thrombosis

A

it is a blood clot that forms within a vein

43
Q

state a common type of venous thrombosis

A

deep vein thrombosis

44
Q

what is deep vein thrombosis

A

it is a blood clot in the deep vein of the leg

45
Q

what is thrombosis

A

it is a term for a blood clot occurring inside a blood vessel

46
Q

what is embolism

A

obstruction of an artery, typically by a blood clot or an air bubble

47
Q

what is thromboembolism

A

obstruction of a blood vessel by a blood clot that has become dislodged from another site in the circulation

48
Q

state the 2 main examples of venous thromboembolism

A

limb deep vein thrombosis

pulmonary embolism

49
Q

what is pulmonary embolism

A

it is a blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream

50
Q

state 2 other examples of venous thromboembolism

A

visceral venous thrombosis

intracranial venous thrombosis

51
Q

what are symptoms of deep vein thrombosis

A

pain, swelling and tenderness in your leg
a heavy ache in the affected area
warm skin in the area of the clot
red skin

52
Q

what are common tests for DVT

A

ultrasound
d-dimer testing
venography

53
Q

what is the most common test for diagnosing DVT

A

ultrasound, sound waves create images showing the blood flowing through the arteries and veins in the affected leg

54
Q

what are symptoms and signs of pulmonary embolism

A
pleuritic chest pain
dyspnoea
haemoptysis
tachycardia
pleural rub on auscultation
55
Q

what are symptoms and signs of massive pulmonary embolism

A
Severe dyspnoea (sudden onset)
Collapse
cyanosis
Tachycardia
Low blood pressure
Raised JVP
May cause sudden death
56
Q

state tests for diagnosis of pulmonary embolism

A
wells score
geneva score
blood tests
d-dimer tests
CT pulmonary angiogram
isotope ventilation/perfusion scan
57
Q

what is the outcome of pulmonary embolism

A

most patient recover fully

development of pulmonary arterial hypertension

58
Q

what are the aims of treatment of venous thromboembolism

A

prevent clot extension
prevent clot embolisation
prevent recurrent clot

59
Q

what is the main treatment of pulmonary embolism

A

anticoagulation

60
Q

what are the parental options of anticoagulation treatment of pulmonary embolism

A

unfractionated heparin

low molecular weight heparin

61
Q

what are the enteral options of anticoagulation treatment of pulmonary embolism

A

warfarin

direct oral anticoagulants

62
Q

what is another treatment for pulmonary embolism that isn’t anticoagulation treatment

A

thrombolysis

thrombolysis is reserved as treatment for massive pulmonary embolism

alteplase is a thrombolytic drug

63
Q

describe prevention of venous thromboembolism in hospital

A

early mobilisation
anti-embolism stockings
mechanical methods of thromboprophylaxis
pharmacological thromboprophylaxis