Pathophysiology of ischaemia & infarction Flashcards
when does an MI occur?
when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle
what are the most common symptoms of an MI?
chest pain or discomfort which may travel into the shoulder, arm, back, neck or jaw, primarily on the left side
how can an MI be recognised by clinical features?
ECG findings
elevated values of biochemical markers of myocardial necrosis
imaging
patholgoy
what is a major cause of death and disability worldwide?
an MI
what refers to changes that occur due to the sudden deprivation of circulating blood
MI
what is ischaemia?
an inadequate blood supply to an organ or part of the body, especially the heart muscles
define hypoxia
deficiency in the amount of oxygen reaching the tissues
state 6 factors affecting oxygen supply
inspired oxygen pulmonary function blood constituents blood flow integrity of vasculature tissue mechanisms
state the 2 factors affecting oxygen demand
the tissue itself and the activity of tissue above baseline value
define an atheroma
localied accumulation of lipid and fibrous tissues in intake of arteries
what correlates to stable angina
established atheroma in coronary artery
what correlates to unstable angina
complicated atheroma in coronary artery
what are clinical consequences of atherosclerosis
MI TIA cerebral infarction abdominal aortic aneurysm peripheral vascular disease cardiac failure
what can coronary artery disease lead to?
an MI
what can a MI lead to?
cardiac failure
