Protein synthesis inhibitors

Question 1

action on 30s ribosomal subunit ?

Answer 1

aminoglycosides
tetracycline

Question 2

action on 50s ribosomal subunit ?

Answer 2

chloramphenicol
macrolides
clindamycin

Question 3

systemic aminoglycosides name ?

Answer 3

STK-GA
Streptyomycin
tobramycin
kanamycin
amikacin
gentamiciin

Question 4

oral aminoglycoside ?

Answer 4

neomycin

Question 5

common properties of aminoglycosides ?

Answer 5

777

Question 6

M/A of aminoglycoside one line ?

Answer 6

protein synthesis I

Question 7

Physical properties ?

Answer 7

hexose ring
& amino sugar
attched by glycosidic linkage

Question 8

M/A of Aminoglycosides ?

Answer 8

778

Question 9

aminoglycoside + penicillin ?

Answer 9

synergistic effect

Question 10

A/E of aminoglycosides ?

Answer 10

ototoxicity
nephrotoxicity
neuromuscular bloackade
hypersensitivity

Question 11

ototoxicity by which drug ? vestibular ?

Answer 11

GS
streptomycin
gentamicin

Question 12

auditory damage by which drug a?

Answer 12

NAK
neomycin
kanamycin
amikacin

Question 13

A + Frusemide >

Answer 13

pharmacological potentiation
+++++++ ototoxicity

Question 14

A + neuromuscular blockade ?

Answer 14

PP
enhance paralysis

Question 14

selective activity of aminoglycoside >

Answer 14

782

Question 15

A + cephalosporins = ?

Answer 15

PP
nephrotoxicity ++++++++++

Question 16

A + vancomycin ???

Answer 16

PP
+++++++++++=nephrotoxicity

Question 17

contraindications of tetracycline ? children ?

Answer 17

fetal teeth - fluroscence + discoloration + enamal dysplasia
fetal bone = defromity / growth inhibition

Question 18

natural tetracycline ?

Answer 18

chlor-oxy T
T

Question 18

semisynthetic T ?

Answer 18

Doxycycline
minocyclinne
demeclocycline

Question 19

A/E of tetracycline ?

Answer 19

N-V-D
Fetal teeth + bone
hepatotoxicity
nephrotoxicity
photosensitization
IM- local irritation
IV - venous thrombi

Question 20

indication of chloramphenicol >

Answer 20

eye infection - tropical use
rickettsial infection
meningococcal meningitis
bacterial meningitis

Question 20

why cholamphenicol used in eye infection <

Answer 20

broad spectrum
penetration of ocular tissues and aqueous humor

Question 21

oxyT vs Doxycycline ?

Answer 21

788

Question 22

A/E of chloramphenicol?

Answer 22

N-V-D Superinfection oral and vaginal candiditis gray baby syndrome

Question 23

when gray baby syndrome occur >

Answer 23

chloramphenicol >50 mg/kg

Question 24

common macrolides ?

Answer 24

ACE\ azithromycin clarithromycin erythromycin

Question 25

alternative of penicillin allergic patient >

Answer 25

M,acrolides

Question 26

macrolides use ?

Answer 26

Upper RTI community acquire P atypical P acne cholera triple therapy in PUD diptheria SSTI WHOOPING COUGH

Question 27

Use of aminoglysides ?

Answer 27

779 12-2-2025 3.55PM

Question 28

aminoglycoside soubiliuty ?

Answer 28

WATER SOLUBLE

Question 29

Old ekjon pt ke drug deyar age ki ki dekhba ?

Answer 29

renal & hepatic function

Question 30

how to assess renal function ?

Answer 30

Creatinine dekhbo

Question 31

RTI e P drug hiseve kon fluroquinolone ?

Answer 31

levofloxacillin

Question 32

RTI e P drug huseve kon penicillin ?

Answer 32

ampicillin corrected 16-2-2025 12.16AM

Question 33

which macrolides in PUD >

Answer 33

clarithromycin

Question 34

why clarithromycin in PUD ?

Answer 34

acid stable macrolides with broad spectrum of anti-bacterial activity

Question 35

others macrolides PUD te na keno ????

Answer 35

higher resistance by H pylori lower gastric penetration less synergy with PPI shorter intracellular effect 16.2.2025 12.19AM

Question 36

why doxycycline in=s better than tetracycline ?

Answer 36

more potent less frerquncy of dosing longer duration of action less incidence of diarrhea' can be used in renal failure

Question 37

treatment of abscess anf boil e ??

Answer 37

cefuroxime clavulanic acid

Question 38

why aminoglycoside not given orally >? // why streptomycin is given IV ???? Munni mam

Answer 38

**Aminoglycosides are not given orally** because they are poorly absorbed from the gastrointestinal tract and must be administered parenterally (IV/IM) to achieve effective systemic concentrations.

Question 39

M/A of chloramphenicol ?

Answer 39

50s ribosomal subunit bind inhibit peptidyl transferases' inhibit peptide bond formation protein synthesis inhibites

Question 40

indication of neomycin ?

Answer 40

preparation for elective bowel surgery hepatic encephalopathy pre-operartive gut sterilization

Question 41

dosing schedule of azithromycin ?

Answer 41

daily dosing

Question 42

indication of carbapenam ?

Answer 42

pneumococcal infection enterobacter infection mixed aerobic and anerobic choice of drug - serious infections caused by extended sprectrum of extended beta lactamase producing gram - bacteria

Question 43

oculotoxic drug name ?

Answer 43

ethambutol chloroquine

Question 44

use of nalidixic acid ?

Answer 44

bacillary dysentry UTI

Question 45

Drugs - ENteric fever + Pregnancy 811

Answer 45

amoxicillin cephalosporins cefuroxime cefixime ceftriaxone

Question 46

name beta lactum drugs ?>

Answer 46

756

Question 47

1st G cephalosporins indication ?

Answer 47

cellulitis SSTI Sinusitis UTI Skin infection 768

Question 48

long acting tetracycline name >

Answer 48

doxyxycline minocylcine

Question 49

short actiing T ?

Answer 49

Oxy T t

Question 50

auditory damage what happening ?

Answer 50

tinnitus hearing loss

Question 51

vestibular damage what happening >

Answer 51

vertigo ataxia loss of balance 12-2-2025 5.45PM

Question 52

oto-toxicity what type of damage ?

Answer 52

sensory

Question 53

oto-toxicity which nerve ?

Answer 53

vestibulocochelar nerve / 8th nerve

Question 54

tetracycline is contraindicated upto which age ?

Answer 54

8 yrs

Question 55

INFECTIVE diarrheas which drugs 813 ??

Answer 55

ciprofloxacillin ampicillin 3 + 4 cephalosporins co-trimoxazole 12.51AM 16.2.25