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Pharmacology-PROF > Protein synthesis inhibitors > Flashcards

Protein synthesis inhibitors Flashcards

1
Q

action on 30s ribosomal subunit ?

A

aminoglycosides
tetracycline

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2
Q

action on 50s ribosomal subunit ?

A

chloramphenicol
macrolides
clindamycin

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3
Q

systemic aminoglycosides name ?

A

STK-GA
Streptyomycin
tobramycin
kanamycin
amikacin
gentamiciin

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4
Q

oral aminoglycoside ?

A

neomycin

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5
Q

common properties of aminoglycosides ?

A

777

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6
Q

M/A of aminoglycoside one line ?

A

protein synthesis I

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7
Q

Physical properties ?

A

hexose ring
& amino sugar
attched by glycosidic linkage

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8
Q

M/A of Aminoglycosides ?

A

778

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9
Q

aminoglycoside + penicillin ?

A

synergistic effect

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10
Q

A/E of aminoglycosides ?

A

ototoxicity
nephrotoxicity
neuromuscular bloackade
hypersensitivity

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11
Q

ototoxicity by which drug ? vestibular ?

A

GS
streptomycin
gentamicin

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12
Q

auditory damage by which drug a?

A

NAK
neomycin
kanamycin
amikacin

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13
Q

A + Frusemide >

A

pharmacological potentiation
+++++++ ototoxicity

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14
Q

A + neuromuscular blockade ?

A

PP
enhance paralysis

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14
Q

selective activity of aminoglycoside >

A

782

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15
Q

A + cephalosporins = ?

A

PP
nephrotoxicity ++++++++++

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16
Q

A + vancomycin ???

A

PP
+++++++++++=nephrotoxicity

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17
Q

contraindications of tetracycline ? children ?

A

fetal teeth - fluroscence + discoloration + enamal dysplasia
fetal bone = defromity / growth inhibition

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18
Q

natural tetracycline ?

A

chlor-oxy T
T

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18
Q

semisynthetic T ?

A

Doxycycline
minocyclinne
demeclocycline

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19
Q

A/E of tetracycline ?

A

N-V-D
Fetal teeth + bone
hepatotoxicity
nephrotoxicity
photosensitization
IM- local irritation
IV - venous thrombi

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20
Q

indication of chloramphenicol >

A

eye infection - tropical use
rickettsial infection
meningococcal meningitis
bacterial meningitis

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20
Q

why cholamphenicol used in eye infection <

A

broad spectrum
penetration of ocular tissues and aqueous humor

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21
Q

oxyT vs Doxycycline ?

22
Q

A/E of chloramphenicol?

A

N-V-D
Superinfection
oral and vaginal candiditis
gray baby syndrome

23
Q

when gray baby syndrome occur >

A

chloramphenicol
>50 mg/kg

24
Q

common macrolides ?

A

ACE\
azithromycin
clarithromycin
erythromycin

25
Q

alternative of penicillin allergic patient >

A

M,acrolides

26
Q

macrolides use ?

A

Upper RTI
community acquire P
atypical P
acne
cholera
triple therapy in PUD
diptheria
SSTI
WHOOPING COUGH

27
Q

Use of aminoglysides ?

A

779

12-2-2025
3.55PM

28
Q

aminoglycoside soubiliuty ?

A

WATER SOLUBLE

29
Q

Old ekjon pt ke drug deyar age ki ki dekhba ?

A

renal & hepatic function

30
Q

how to assess renal function ?

A

Creatinine dekhbo

31
Q

RTI e P drug hiseve kon fluroquinolone ?

A

levofloxacillin

32
Q

RTI e P drug huseve kon penicillin ?

A

ampicillin

corrected
16-2-2025
12.16AM

33
Q

which macrolides in PUD >

A

clarithromycin

34
Q

why clarithromycin in PUD ?

A

acid stable macrolides
with broad spectrum of anti-bacterial activity

35
Q

others macrolides PUD te na keno ????

A

higher resistance by H pylori
lower gastric penetration
less synergy with PPI
shorter intracellular effect

16.2.2025
12.19AM

36
Q

why doxycycline in=s better than tetracycline ?

A

more potent
less frerquncy of dosing
longer duration of action
less incidence of diarrhea’
can be used in renal failure

37
Q

treatment of abscess anf boil e ??

A

cefuroxime
clavulanic acid

38
Q

why aminoglycoside not given orally >?

A

Aminoglycosides are not given orally because they are poorly absorbed from the gastrointestinal tract and must be administered parenterally (IV/IM) to achieve effective systemic concentrations.

39
Q

M/A of chloramphenicol ?

A

50s ribosomal subunit bind
inhibit peptidyl transferases’
inhibit peptide bond formation
protein synthesis inhibites

40
Q

indication of neomycin ?

A

preparation for elective bowel surgery
hepatic encephalopathy
pre-operartive gut sterilization

41
Q

dosing schedule of azithromycin ?

A

daily dosing

42
Q

indication of carbapenam ?

A

pneumococcal infection
enterobacter infection
mixed aerobic and anerobic
choice of drug - serious infections caused by extended sprectrum of extended beta lactamase producing gram - bacteria

43
Q

oculotoxic drug name ?

A

ethambutol
chloroquine

44
Q

use of nalidixic acid ?

A

bacillary dysentry
UTI

45
Q

Drugs - ENteric fever + Pregnancy
811

A

amoxicillin
cephalosporins
cefuroxime
cefixime
ceftriaxone

46
Q

name beta lactum drugs ?>

47
Q

1st G cephalosporins indication ?

A

cellulitis
SSTI
Sinusitis
UTI
Skin infection

768

48
Q

long acting tetracycline name >

A

doxyxycline
minocylcine

49
Q

short actiing T ?

50
Q

auditory damage what happening ?

A

tinnitus
hearing loss

51
Q

vestibular damage what happening >

A

vertigo
ataxia
loss of balance

12-2-2025
5.45PM

52
Q

oto-toxicity what type of damage ?

53
Q

oto-toxicity which nerve ?

A

vestibulocochelar nerve / 8th nerve

54
Q

tetracycline is contraindicated upto which age ?

55
Q

INFECTIVE diarrheas which drugs

813 ??

A

ciprofloxacillin
ampicillin
3 + 4 cephalosporins
co-trimoxazole

12.51AM
16.2.25

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