Benzodiazepine+Barbiturates CNS

Question 1

Benzodiazepine Ultra short acting ?

570

Answer 1

CloraZepate

570

Question 2

Benzodiazepine short acting ?

Answer 2

1. TriAzolam
2. MidAzolam
3. OxaZepam

570

Question 3

Long acting benzodiazepine ??

Answer 3

1. Diazepam
2. Flurazepam
3. Parazepam
4. Quazepam
5. Nitrazepam

570

Question 4

Benzodiazepine intermediate acting ??

Answer 4

1. AlprAzolam
2. EstAzolam
3. Lorazepam
4. Temazepam

570

Question 4

Major inhibutory Neurotransmitters in the CNS ?

Answer 4

GABA

571

Question 5

GABA receptor which type of channel ??

Answer 5

Cl- ion channel

572

Question 6

Structure of GABA receptor ??

Answer 6

Pentameric structure

Question 6

Two binding site for GABA location ??

Answer 6

Between ALPHA – BETA

572

Question 7

BZ binding site in GABA receptor ??

Answer 7

Between ALPHA–GAMA

572

Question 8

Barbiturate binding site in GABA receptor >??

Answer 8

Between ALPHA – BETA
Different Site

572

Question 9

Alpha-1 subunit binding drugs name ??

Answer 9

1. Zolpidem
2. 2.Zaleplon
   3.Eszopiclone

572

Question 10

Which sedative-hyptonics has low affinity for GABA ??

Answer 10

BZ

Question 11

Anticonvulsant use of BZ ??

Answer 11

1. Epilepsy / Status epilecticus
2. Seizure

573

Question 11

Anesthesia use of BZ&raquo_space;??

Answer 11

Diazepam
Lorazepam
Midazolam

573

Question 12

How to inc the affintiy ??

Answer 12

Baclofen

572

Question 13

Effeccts of BZ on diff stages of NREM sleep ?

Answer 13

1. Stage-2 NREM duration inc
2. Stage-4 NREM duartion dec

NREM- Non Rapid Eye Movement

573

Question 14

Sedation effects of BZ ??

Answer 14

1. dec anxiety
2. Euphoria
3. Loss of self control
4. Impaired judgment
5. Anterograde amnesia

573

Question 15

Drugs that enhance GABAergic action ??

Answer 15

1. BZ
2. Barbiturates-Phenobarbitone
3. Valproate
4. Vigabatrin
5. GabaPentin

Question 16

Mechanism of BZ shortly ??

My own way _____———–

Answer 16

1. BZ binds with GABA-R
2. inc affinity of GABA-R to GABA
3. GABA binds with GABA-R
4. inc frequency of opening Cl- channel
5. inc influc of Cl- ions
6. Hyperpolarization
7. No Action Potential
8. No excitability
9. CNS depression / Sedation / Hypnosis

571

Question 17

Metabolism of BZ ?? Location ??

Answer 17

Liver

Question 18

Ultra short acting barbiturates /

Answer 18

1. thiopental Na
2. methohexital

Question 19

short acting barbiturates ?

Answer 19

1. pento + seco
2. barbital

Question 20

intermediate acting barbiturates ?

Answer 20

amo-apro-buto
barbital

Question 21

long acting Bt ?

Answer 21

phenobarbitone/phenobarbital

Question 22

M/A of Bt ?

Answer 22

same as BZ but Inc duration of opening of Cl channel

Question 23

indications of Bt ?

Answer 23

1. GA-thiopental Na 2. congenital hyperbilirubinemai - phenobarbitone ' 3. epilepsies 4. partial seizure 5. eclampsia 6. GTCS 7. Status epilepticus 8. sedation 9. hypnosis 10. anticonvulsant

Question 24

how congenital hyperbilirubinemia by Bt ?

Answer 24

1. induce hepatic drug metabolizing enzyme 2. inc conc of glucoronyl transferase 3. inc conjugation of bilirubin 4. in metabolism of bilirubin 5. dec serum B level ``

Question 25

Bt + Warferin = ?

Answer 25

inc metabolism of warferin dec anti-coagulant effect inc coagulation=thrombosis

Question 25

Bt + OCP = ?

Answer 25

1. inducre epatic microsomal enzyme 2. inc metabolism of OCP 3. Failure of contraception

Question 26

A/E of Bt ?

Answer 26

1. drowsiness 2. hangover effect 3. addiction 4. tolerance 5. enzyme induction' 6. allergy 7. skin lesion 8. asthma 9. oligurtia 10. dependence

Question 27

antidote of Bz ?

Answer 27

FLUMAZENIL

Question 28

A/E of BZ ?

Answer 28

1. hangover effect 2. somnolence 3. drowsiness 4. anterograde amnesia 5. impraired judegement 6. lethaylethargy 7. cardiac failure 8. respiratory center depression 9. memory loss 10. rhabdo,yosis

Question 29

why Bz >>> Bt ?

Answer 29

1. high TI = need more dose 2. have antidote=flumazenil 3. donot induce drug metabolizing enzymes