AntiPlatelet Drugs

Question 1

AntiPlatelet drugs name ?

Answer 1

Cyclooxygenase inhibitor-
Inhibition of Thromboxane A2 synthesis
= Aspirine

ADP P2Y12 receptor inhibitors = Inhibiton of ADP induced platelet
1. clopidogrel
2. prasugrel
3. ticegrelor
4. cangrelor
5. ticlopidine

Inhibition of Glycoprotein IIB/IIIa receptors
1. abciximab
2. tirofiban
3. eptifibatide

phosphodiphosphodiesterase inhibitor
=cilostazol

inhibitor of adenosine uptake
=dipyridamole

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Question 2

Mechanism of Aspirine ?

Answer 2

=Acetylates and inactivate COX IRREVERSIBLY
=Platelets are unable to synthesize new enzyme
=COX activity is lost
=Prevention of formation of Thromboxane A2 & Prostacyclin
=Thromboxane A2= P Aggreagation
=Prostacyclin= P A inhibit
=LDA= Abolish synthesis of TA2
=But no impairmemnt of Prostacyclin
=P- Platelet aggregation inhibit
= no thrombus

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Question 3

Low dose aspirine ?

Answer 3

75-325 mg/Day

Question 4

Indiacation of aspirine ?

Answer 4

1. MI
2. DVT
3. Ischrmic srtoke
4. PVD
5. TIA
6. UA
7. Atrial fibrillation

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Question 5

A/E od aspirine ?

Answer 5

1. Gastric irritation
   G hemorrhage
   G perforation
   Precipitation of asthma

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Question 6

Contraindiaction of aspirine ?

Answer 6

1. PUD
2. COPD
3. ASTHMA
4. 🤰
5. Coagulation disorder

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Question 7

Mechanism of ClopiDogrel?????

Answer 7

Block ADP receptor=Irreversibly in platelet membrane
=no adp binf to adp receptor
=no activation of gpiia/iiib
=no platelet aggregation

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Question 8

Low dose aspirine i inhibit which enzyme ?

Answer 8

COX1= dec thromboxane A2

Question 9

High dose aspirine block which enzyme ?

Answer 9

COX1 COX2