Adrenergic Pharmacology

Question 1

Adrenergic Drugs

Answer 1

Non selective
1.Adrenaline
2.Nor adrenaline
3.Isoprenaline
4.Dopamine

Selective

Alpha-1 Selective
1.Phenylephrine
2.Methoxamine

Alpha-2 Selective
1.Clonidine
2.Guanfacine
3.Alpha methyl dopa

B-1 selective
1.Dobutamine

B-2 selective
1.Salbutamol
2.Salmeterol
3.Terbutaline
4.Fenoterol
5.Ritodrine

Question 2

site of synthesis of adrenaline ??

Answer 2

adrenal medulla

240

Question 3

site of synthesis of nor adrenaline ??

Answer 3

adrenergic nerve ending

240

Question 4

Beta 1 receptor site ??

Answer 4

• heart
• JG cells of kidney

246

Question 4

steps of synthesis of Ad ??

Answer 4

240

Question 5

which one is Pseudo-NT >??

Answer 5

Adrenaline
site - adrenal medulla
other NT - nerve ending

243

Question 6

B1 function ??

Answer 6

• inc HR - FOC - CV - BP
• Inc renin secretion

246

Question 7

Beta 2 site ??

Answer 7

• arterioles of heart and skeletal muscles
• smooth muscles of - bronchusn - gall bladder - urinary bladder - uterus - GIT
• Liver
• endocrine pancreas

246

Question 8

B2 function ??

Answer 8

• Vasodilation
• bronchodilation
• Relaxation
• inc secretion of insulin & glucagon
• glycogenolysis

246

Question 9

Beta 3 site ??

Answer 9

adipose tissue

Question 10

beta 3 function ??

Answer 10

lipolysis

247

Question 10

alpha 1 function ??

Answer 10

• Vasoconstriction
• Mydriasis
• glycogenolysis
• gluconeogenesis

246

Question 11

Alpha 1 site ??

Answer 11

1. eye - iris radial muscle
2. sphincter of whole body except pupil
3. uterus , pragnant
4. sweat & salivary gland
5. Liver
6. arteriole of skin heart kidney skeletal muscle

Question 12

Alpha 2 site ??

Answer 12

• arterioles of heart skin salivary gland
• pre synaptic nerve terminal
• endocrine pancreas
• adipose tissue
• platelet

246

Question 13

why Adrenergic receptors are called sutoreceptors ??

Answer 13

they are found in - presynaptic neurons

247

Question 13

which receptors inc BP ??

Answer 13

• B1
• A1 - Vasoconstriction

Question 14

which adrenrgic drugs in premature labour ??

Answer 14

ritodrine

249

Question 15

Indications of adrenaline ??

Answer 15

1. Anaphylactic shock
2. anesthetics
3. status asthmaticus
4. glaucoma
5. cardiac arrest
6. nasal bleeding
7. nasal decongestant

AA SGC NN

Question 16

contraindications of Ad&raquo_space;

Answer 16

• HTN
• IHD
• DM
• BPH
• Arrthyrmia
• hyperthyroidism

253

Question 17

A/E of Ad ??

Answer 17

1. tremor
2. restlessness
3. insomnia
4. anxiety
5. constipation
6. retention of urine
7. hyperglycemia
8. HTN
9. Sinus tachycardia
10. ventricular arrtyhmia

253

Question 18

other name of Ad ??

Answer 18

epinephrine

Question 19

role of Ad in Anaphylactic shock ??

Answer 19

• A1 = Vasoconstriction = + BP
• B1 = + BP
• B2 = Bronchodilation
• Mast cell = inhibit histamine & vasoactive amine

255

Question 20

role of dopamine in Cardiogenic shock ??

Answer 20

• B1 = + BP
• D1 = renal vasodialtion = + RBF = +GFR = improve renal fucntion

256

Question 21

dopamine receptors anme ??

Answer 21

A1
A2
B1
D1
D2

Question 22

Nasal decongestant drugs name ??

Answer 22

• XyloMetazoline
• oxymetazoline
• adrenaline
• ephedrine
• pseduo ephdrine

263

Question 23

reversible A1 blocker name ??

Answer 23

1. prazosin
2. teraZ
3. doxaZ
4. Tamsulosin
5. alfuzosin

268

Question 24

reversible A2 blockers name ??

Answer 24

• Yohimbine

Question 25

reversible A1+2 ??

Answer 25

Phentolamine

Question 26

irreversible A1+2 drugs name ??

Answer 26

phenoxybenzamine

Question 27

indications of Alpha blockers&raquo_space;

Answer 27

• pheochromocytoma
• HTN emergency
• chronic HTN
• BPH
• erectile dysfunction
• PVD
• Distal urethral stone

269

Question 28

A+B blocker «

Answer 28

labetalol

Question 29

indication of labetalol ??

Answer 29

1. Emergency HTN
2. Pheochromocytoma

268

Question 30

erectile dysfucntion drugs name ??

Answer 30

• phentolamine
• alprostadil
• papaverine
• sildenafil
• taaldafil
• vardenafil

268