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Pharmacology-PROF > NSAID > Flashcards

NSAID Flashcards

1
Q

COX-2 selectivity - very selective ?

A

etori-coxib

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2
Q

COX-2 moderately sslective ?

A
  1. rofe-coxib
  2. cele-coxib
  3. etodolac
  4. meloxicam
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3
Q

COX-2 weakly selective ?

A
  1. diclofenac
  2. sulindac
  3. piroxicam

D-S-P

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4
Q

Most potent NSAID ?

A

KETOROLAC

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5
Q

Which NSAID in BD ?

A

etoricoxib

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6
Q

salicylates - NSAID ?

According to chemical nature & structure

A
  1. aspirine
  2. sulfasalazine
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7
Q

propionic acid derivatives ?

A
  1. ibu-feno-keto=PROFEN
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8
Q

acetic acid derivative name ?

A

1indomethacin
etodolac
sulindac

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9
Q

fenamic acid derivatives NSAID ?

A
  1. mefenamic acid
  2. tolfenamic acid
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10
Q

enolic acid derivatives ?

A

piro-teno-melo-XICAM !!

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11
Q

CVS safe NSAID ?

A

naproxen q

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12
Q

Commonly used NSAID ?

A
  1. diclofenac
  2. aspirin
  3. aceclofenac
  4. ketorolac
  5. etoricoxib
  6. ibuprofen
  7. naproxen
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13
Q

Indications of Aspirin/NSAID ?

A

Anti
inflmmatory-pyretic-platelet-analgesic

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14
Q

renal safe NSAID ?

A

sulindac

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15
Q

children safe NSAID ?

A

ibuprofen

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16
Q

which NSAID is Bronchial astham safe ?

A

ibuprofen

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17
Q

which NSAID used as post-operative & inj ?

A

ketorolac

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18
Q

which NSAID is 🤰 safe ?

A

paracetamol

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19
Q

antidote of paracetamol ?

A
  1. N-acetylcystine
  2. methionine

728

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20
Q

overdose of paracetamol A/E ?

A
  1. Hepatotoxicity
  2. renal necrosis
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21
Q

Contraindications of NSAID ?

A
  1. active bledding peptic ulcer
  2. Chronic PUD
  3. CLD
  4. bronchial asthma
  5. gout
  6. bleeding disorder
  7. imediatly after burn - diye dile -Curling ulcer
  8. swine flu & influenza
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22
Q

why NSAID/Aspirin is not given in a viral infected child >??

A

reyes syndrome

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23
Q

commonly used analgesics?

A
  1. paracetamol
  2. aspirin
  3. diclofenac
  4. mefenamic acid
23
Q

which NSAID is used as analgesic in postoperative pain management?

A
  1. diclofenac
  2. ketorolac
24
Q

what is Reyes syndrome ?

A

swelling in the liver and brain

25
Q

which NSAID IN primary dysmenorrhea ?

A

mefenamic acid

25
Q

which NSAID is used as tocolytics ?

A
  • indomethacin
  • sulindac
26
Q

indicatttions of NSAID ??

A
  • AnalgesicAnalgesics
  • anti-inflammatory-antipyretics - antiplatelet
  • tocolytics
  • patency of ductus arteriosus
  • primary dysmenorhhe
27
Q

which NSAID used in patency of ductus arteriosus ?

A

indomethacin >

28
Q

which NSAID used in Gout ?

A

indomethacin

29
Q

risk of paracetamol in 🤰?

A

3rd trimester - risk of premature closure of the ductus arteriosus

30
Q

less CVS effect of which NSAID ?>

A
  • celecoxib
  • naproxen
31
Q

which COX-2 inhibitor are not in market ? reason&raquo_space;

A
  1. rofecoxib
  2. valdecoxib
  3. due to their increasing CVS risk
32
Q

recent status of COX-2 ?

A

not in market !!!!

33
Q

why COXIB&raquo_space;> NSAID ?

A
  1. no GIT bleeding
  2. donot precipiatet Brionchail asthma
  3. donot cause gastric mucosal damage

732

34
Q

what if - ibuprofen is taken regularly ??

A

cardio-protective action of aspirin may block

35
Q

which NSAID act on both brain & periphery ?

A
  1. ibuprofen
  2. aspirin
  3. ketoprofen
  4. diclofenac
36
Q

overdose of aspirin effect ?

A

NaOH er maddhome Ph of urine alter - urine alkalization

37
Q

A/E of NSAID ??

GIT sobar age bolte hobe

A
  1. ab pain
  2. peptic ulcer
  3. dyspapsia
  4. ulceration
  5. bleeding
38
Q

Other A/E of NSAID “?

A

CNS= headache + tinnitus+ dizziness
respiratory = bronchospasm
CVS=fluid retemtion + HTN + edema
hypersensitivity
neutropenia + thrombocytopenia

39
Q

why bronchospasm by NSAID >?

A

by reducing bronchodilator Prostaglandin synthesis
thats why NSAID aggravate Bronchail asthma

40
Q

why aspirin is stopped one week before surgery ?

41
Q

antiplatelet effect of aspirin ?

42
Q

analgesic effect of NSAID ?

43
Q

Anti-pyretic effects of NSAID /

44
Q

anti-inflammatory effect of NSAID ??

45
Q

NSAID + warferin ?

A

risk of bleeding

46
Q

nsaid + fluroquinolone ?

A

risk of convulsion

47
Q

nsaid + sulfonylurease ? oral hypoflycemic agents = ??

A

inc action & duration

48
Q

nsaid + ACEi /ARB = ?

A
  1. RENAL impairment \
  2. hyperkalemia
49
Q

nsaid + diuretics = ?

A

dec effects of diuretics

50
Q

contraindications of COX-i ?

A
  • IHD
  • HTN
  • CVD
  • Cardiac failure

733

51
Q

analagesic effect excellent /

52
Q

aspirin dose /

A

75-150 mg per day

53
Q

anti-inflammatory drugs name /

A
  • steroidal = cortisone + hydrocortisone
  • non-steroidal = Acetaminophen + aspirin

Pharmacology-PROF (37 decks)

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