Laxatives - GI Pharma Flashcards
Bulk forming laxatives ??
- Ispaghula husk
- Bran
- Psyllium
- Methylcellulose
- Polycarbophil - Synthetic fibers
546
Osmotic laxatives name ??
- Mg Hydroxide
- Mg Citrate
- Na Phosphate
- Sorbitol
- Lactulose
- Polyethylene Glycol- PEG
546
Stool softeners ??
- Docusate
- Liquid paraffin /Mineral oil
- Glycerin suppository
546
Stimulant laxatives / Cathartics name ??
- Senna
- Aloe
- Bisacodyl
- Cascara
547
Chloride channel activator name ??
1.LubiProstone
2.LinaClotide
3.PleCanatide
Serotonin 5HT4 receptor agonists name. ?
1.Tegaserod
2.CisaPride
3.PruCaloPride
Pro kinetic agents ??
1.Serotonin 5HT4 receptor agonists
2.Ophoid receptor antagonists
3.Misoprostol
Non pharmacological approach of constipation ??
- Fiber rich diet = (20-30) g/day
- Adequite fluid intake
- Regular exercise
- The heedinf of natures call
- Avoid constipating drugs
547
A/E of bulk forming laxatives ??
- Flatus
- Ab bloating
548
Indications of lactulose ??
- Constipation
- Hepatic encephalopathy
- Diagnostic procedure-Colonoscopy/surgery
548
Contraindications of Bulk forming laxatives ??
- Megacolon
- Megarectum
- Intestinal obstruction
- Fecal impaction should be treated before fibre supplementation
548
A/E of lactulose ??
- Hypermagnesemia
- Severe flatus
- Cramps
- IV volume depletion
- Electrolyte fluctuations
548
Contraindications of lactulose ??
- Renal F
- Severe cardiac disease
548
Stimulant laxatives/Bisacodyl mechanism ??
- direct stimulation of the ENS
- inc colonic electrolyte & fluid secretion by irritation
549
Indications of SL/Bisacodyl ??
- Constipation
2.Long term tx of consstipation
549
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A/E of SL ??
- Diarrhea
- Ab cramps
549
Enema ??
procedure of introducing liquids into the rectum and colon via the anus
549
A/E of stool softners ??
- impair absoprtion of adek vitamin
- Severe lipid pneumonitis
549