Anti-Malarial Drugs

Question 1

drugs for radical / relapse cure ??

831

Answer 1

primaquine
15 mg/kg for 14 days

Question 2

less effacious Blood s ?

Answer 2

Fansider = sulfadoxine 500mg + pyrimethamine 25 mg

Question 2

drugs for causal prophylaxis ??

Answer 2

• doxycycline
  primaquine

Question 3

high effacious n=blood schizonticides ??

Answer 3

1. chloroquine
   mefloquine ‘
   quinine
   quinidine

Question 4

gametocides name ??

Answer 4

primaquine
chloroquine
quinine
artemether

831

Question 5

Treatment of Vivax malaria ??

Answer 5

Chloroquine + Primaquine

Question 6

why C + P = ?

841

Answer 6

C = Highly effective blood schizonticides
but not effective against liver stage parasites

P = active against liver stages of all human malaria parasites
aactive againts dormant hypnbotic stage of P vivax ovale
P= Radical cure

841

Question 7

C dose in P vivax ??

Answer 7

• 1 = 10mg/kg = 4 tabs
  2 = 10mg/kg = 4 tabs
  3 = 5mg/kg = 2 tabs

Question 8

P doses in P vivax ??

Answer 8

4th day = 15 mg daily for 14 days
1 tab = 15 mg

Question 9

Drug of choice in P vivax ??

Answer 9

Chloroquine

C 3 days + P 14 days

Question 10

drug of choice in P falciparum ??

Answer 10

Quinine

832

Question 11

1st line Tx for uncomplicated C resistant P falciparum malaria ??

Answer 11

Artemether + Lumefantrine
combination therapy = ACT

Question 12

ACT dose fro P f ??

Answer 12

6 doses 3 days

Question 13

Alternative Tx for P f ??

Answer 13

Q 7 days + Tetracycline / Doxycycline / Clindamycin (7 days )

Question 14

trade name of ACT ??

Answer 14

Coartem

Question 15

Route of administration of Coartem ??

Answer 15

oral

Question 16

🤰 catagory of coartem ??

Answer 16

C

Question 17

Coartem serious side effects ??

Answer 17

• prolonged QT syndrome
  anaphylaxis

Question 18

Side effects of coartem <»»

Answer 18

• muscle & joint pain
  fever
  loss of appetite
  headache

833

Question 19

Complicated / cerebral malaria Tx ??

Answer 19

Artesunate - 2.4mg/kg IV
/
Quinine salt IV
/
Artemether IM - 3.2mg/kg

Question 20

If C resistance moderate/ absent chemoprophylaxis ??

Answer 20

C + Proguanil 150 mg + 100 mg

Question 21

drugs for chemoprophylaxis
if C resistance High ??

Answer 21

Mefloquine 250mg
/
doxycycline 100mg
/
Malarone 1 tab from 1-2 days before travelling tooo 1 week after return

Question 22

all trimester pregnancy safe anti-malarial drugs ??

Answer 22

chloroquine
quinine
artemether
artesunate

Question 23

2/3 trimester P safe ??

Answer 23

fansider
mefloquine

Question 24

why Atemether + Lumefantrine ??

Answer 24

A = Multidrug resistant P f malaria
quinine resistant
Uncomplicated & severe F malaria

L = Improved efficacy
prevent appearance of artemether resistant parasites

Question 25

Quinine + Mefloquine = ??

Answer 25

inc risk of seizure
heart arrhythmia

Question 26

Quinine + warfarin + digoxin = ??

Answer 26

inc plasma level

836

Question 27

M/A of chloroquine ??

Answer 27

837

Question 27

Pharmacological effects of Chloroquine ??

Answer 27

837

Question 28

M/A of quinine ??

Answer 28

836

Question 29

A/E of chloroquine ??

Answer 29

• hypersensitivity
  anorexia
  N-V-D-Ab pain
  haemolysis
  psychosis
  confusion ‘seizure
  Hypotension
  ECG changes

838