Anti-Psychotic Drugs

Question 1

Biological/Chemical basis of schizophrenia??

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Answer 1

Dysfunction of the mesolimbic /mesocortical dopaminergic neurons

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Question 2

Serotonin hypothesis of schizophrenia?

Answer 2

Inc serotonin activity
5HT-2A R blocker = Clozapine , Quetiapine

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Question 3

Dopamine hypothesis of schizophrenia??

Answer 3

Excessive dopaminergic activity in the brain is responsible for schizophrenia

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Question 4

Glutamate hypothesis of schizophrenia???

Answer 4

1. Hypofunction of NMDA R
2. GABAergic interneurons
3. Leading to diminished inhibitory influences on neuronal function
4. Contributed to – Schizophrenia

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NMDA= N Methyl D Aspartate

Question 5

Dopamine hypothesis of schizophrenia??

Answer 5

1. Inc Brain Dopamine D2 R
2. D R D2 supersensitivity
3. Inc dopamine level

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Question 6

Typical neuroleptic drugs M/A ??

Answer 6

Competitive blocking of dopamine Receptors

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Question 7

Why M/A of atypical antipsychotics ?/

Answer 7

Block of serotonin & dopamine R

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Question 8

Second generation / Atypical antipsychotic drugs why ??

Answer 8

They have extra pyramidal adverse effects

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Question 9

Phenothiazine derivatives drug name ??

Answer 9

1. Chlorpromazine
2. Thioridazine
3. PerPhenazine
4. FluPhenazine

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Question 10

Typical anti-psychotic drugs ?>?

Answer 10

1. Chlorpromazine
2. Thioridazine

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Question 11

BuTyroPhenone derivatives drugs name ??

Answer 11

HaloPeridol

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