Lipid Lowering Drugs+ Fibrinolytic

Question 1

Lipid lowering drugs name ?

Answer 1

Predominantly cholesterol lowering agents

HMG-CoA Reductase inhibitor (Statin)
AtOR-rosu-lo-flu-sim-pita—-vastatin

Cholesterol absorption inhibitor
eztimibe

Bile acid binding resin
colestipol

niacin-V-B3

Predominately TG lowering agents
Fibrates/Fibric acid derivatives - FenoFibrate

Highly polyunsaturated long chain n=3 fatty acids
Eicosapentanoic acid
Docosahexanoic acid

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Question 2

Mechanism of Atorvastatin

Answer 2

Inhibit HMG-CoA REDUCTASE
=block the rate limiting steps of cholesterol synthesis
=dec cholesterol synthesis
=dec VLDL LDL

Increase LDL receptor
=inc cell surface LDL receptor
=inc binding of LDL WITH ITS RECEPTOR
=inc internationalization
=inc catabolism of LDL
=dec plasma cholesterol

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Question 3

Indication of atorvastatin ?

Answer 3

1. Hyperlipidemia
2. Dyslipidemia
3. After acute coronary syndrome

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Question 4

Atorvastatin in Heart disease ?

Answer 4

1. dec LDL
2. inc stability of atherosclerotic lesion
3. after acute coronary syndrome

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Question 5

A/E of atorvastatin ?

Answer 5

1. Myopathy
2. Myalgia
3. Myositis
4. Rhabdomyolysis
5. Biochemical abnormalities in LFT
6. Inc bleeding tendency

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Question 6

Contraindications of Atorvastatin ?

Answer 6

1. Nursing child
2. Preganancy
3. Children
4. Teenegers

Question 7

Mechanism of Fenofibrate ?

Answer 7

1. Via LPL = inc lipolysis of TG
2. dec VLDL
3. dec TG
4. Stimulate PPAR-Alpha = via LPL = Via LPL = inc lipolysis of TG

LPL= Lipoprotein Lipase
PPAR= Peroxisome Proliferator Activated Recepto

Question 8

Indication of fenofibrate ?

Answer 8

1. HyperTriGlyCeridamias
2. DysBetaLipoProteinema

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Question 9

Contraindication of fenofibrate ?

Answer 9

1. Preganancy
2. Renal f
3. Hepatic f
4. Lactation

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Question 10

A/E of fenofibrate ?

Answer 10

1. Myopathy
2. Myalgia
3. Myositis
4. inc risk of bleeding
5. inc risk of gall stone formation
6. GIT abnormalities

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Question 11

which one is mostly used ?

Answer 11

fenofibrate

12-2-2025
9.40PM

Question 12

Fibrinolytic / thrombolytic drugs name ?

Answer 12

streptokinase
urokinase
alte-plase
rete-plase
tenecte-plase

Question 13

can plasmin be act as fibrinolytic ?

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Answer 13

no
antiplasmin in plasma will inhibt it

Question 13

M/A of streptokinase ?

Answer 13

S + plasminogen
S-P complex
conversion of plasminogen ———– plasmin
degradation of – fibrinogen + fibrin + factor - 5
7
dissolution of clot inthe embolus / thrombus
re-opening of blood vessel
inc blood flow
releirf MI

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Question 14

Indication of streptokinase ?

Answer 14

acute MI
DVT ‘
PE
PVD
arterio-venous shunt

Question 15

A/E of streptokinase ?

Answer 15

bleeding disorder
hypersensitivity
N-V
Multiple micro-emboli