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Pharmacology-PROF > Anti-TB Drugs > Flashcards

Anti-TB Drugs Flashcards

1
Q

1st line drug of TB ?

A
  1. isoniazid
  2. rifampicin
  3. ethambutol
  4. pyrizinamide
  5. rifabutin
  6. rifapentin
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2
Q

2nd line drug ?? TB

A
  1. levofloxacin
  2. moxifloxacin
  3. bedaquiline
  4. cycloserine
  5. clofazimine
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3
Q

New cases condition ?

A
  1. bacteriologically + PTB pt
  2. bacteriologically - PTB pt
  3. Extra PTB
  4. TB + HIV coinfected
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4
Q

new cases Intensive phase & continuation phase ?/

A

I= 2-HRZE
C=4HR

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5
Q

if no resistance to TB drug Tx ?

A

6-HRZE

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6
Q

Clinically diagnosed PTB ? Tx /

A

6-HRZE

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7
Q

Complicated TB ? Tb meningitis bopne,neuroilogical >?? Tx ?

A

12-HRZE+ Levofloxacin
I=2 HRZELfx
C=10HRZELfx

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8
Q

if isoniazid resistant R susceptible in bacteriologically confirmed PTB ?Tx ??

A

6-HRZE-Lfx

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9
Q

isoniazid Indication ?

A
  • TB
  • Latent TB
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10
Q

Pyrizinamide & Ethambutol indication ?

A

TB

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11
Q

Rifampicin indication ?

A
  1. TB
  2. leprosy
  3. pneumococcal
  4. streptococcal
  5. H influenza
  6. prosthetic valve endocarditis
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12
Q

H - A/E ??

A
  1. hepatitis
  2. peripheral neuropathy
  3. N-V
  4. fever
  5. skin rashes
  6. SLE
  7. convulsion
  8. hallucination
  9. memory loss
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13
Q

R - A/E ?

A
  1. Hepatitis
  2. cholestatic jaundice
  3. ATN
  4. proteinuria
  5. nephritis
  6. thrombocytopenia
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14
Q

In R dx Pt ke ki advice dibo ??

A

Harmless orange/red coloration of saliva urine sweat tears contact lens

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15
Q

Z - A/E ??

A
  1. Hyperuricemia
  2. N-V
  3. hepatotoxicity
  4. photosensitivity’s
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16
Q

why Hyperuricemia in Z ?

A

dec- uric acid excretion

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17
Q

E - A/E ?

A
  1. retrobulbar neuritis
  2. loss of visual acuity
  3. red green colour blindness
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18
Q

hepatotoxic Anti-TB drug ?

A

H-R-Z

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19
Q

optic neuritis Tx ?

A

HRZ- 50-75-100
HR-(50-75) Mg
E is given separately as tablet

20
Q

INH full form ?

A

Isonicotinic acid hydrozide

21
Q

Fast acetylation result ?

A

Hepatotoxicity

22
Q

slow acetylation result z?

A

neuropathy

23
Q

Hepatoxicity M/A ?

A
  1. INH repid aceylators
  2. more metabolism in liver
  3. more accumulation of hepatotoxic acetyl hydrazine
24
Q

neuropathy M/A ?

A
  1. S,low acetylators
  2. less metabolism in liver - less hepatotoxicity
  3. less excretion of INH by kidney
  4. morre plasma conc of INH
  5. INH promote excretio n of pyridoxine
  6. pyridoxine deficiency
  7. peripheral N
25
Q

PN - pt Sign ?

A

loss of sensations

26
Q

how to avoid PN ?

A

Vitamin-B6 = Pyridoxine
in a dosage as low as 10mg/day

27
Q

how to avoid heaptotoxicity ?

A

LFT
if SGPT level is 5times normal = discontinu INH

28
Q

M/A of INH = 1 Line ?

A

inhibits synthesis of mycolic acid

29
Q

M/A of INH ?

A
  • INH=Prodrug - activated by katG = mycobacterial catalase peroxidase
  • INH forms a covalent bond with Acyl caarrier protein(AcpM) + Beta Keto acyl carrier protein(KasA)
  • Block mycolic acid synthesis
  • cell wall of mycobacterium is disrupted ‘
  • bacterial cell death
30
Q

prominent hepatotoxicity by which drug ?

A

Z

31
Q

M/A of RIfampicin ?

A
  1. binds with beta subunit of bacterial DNA dependent RNA polymerase
  2. inhibit RNA syn thesis
  3. no protein synthesis
  4. no growth & multiplication
32
Q

enzyme induction which drug ?

A

Rifampicin

33
Q

R + Wrferin ?

A

inc thrombosis = thromboembolic disease

34
Q

R + OCP = ?

A

Unwanted pregnancy

35
Q

R + Anticonvulsants >???

A

convulsion

36
Q

role of rifampicin as Anti-TB drug ?

A
  1. bactericidal
  2. readily penetrates most tissues & into phagocytic cells
  3. kill organism that are poorly accesible to many other drugs
  4. intracellular + nextracellular
37
Q

Z - M/A ?

A
  • Z taken up by macrophage
  • active from of drug - Pyrazinoic acid by mycobacterial pyrazinamidase
38
Q

why 2nd line drug is essential /

A
  1. resistance to 1st line
  2. failure to clinical response
  3. serious Tx- limiting ADR
  4. when expert are available to deal with the toxic effects
39
Q

role of steroid in TB ?

A
  1. Bilateral adrenal TB
  2. TB meningitis - pleural effusion - peritonitis -pericarditis - of ureter - renal TB - In AIDS patient
40
Q

which TB drug in chidren /?

A

Stretomycin

41
Q

why e is not given in children?

A

optic neuritis
baccha ra bolte parbe na

42
Q

combination of TB drug ? why ?/

A
  1. to broaden the spectrum coverage
  2. to prevent development of resistance
  3. to shorten duration of action
  4. reduce toxic effect of a large dose of a single dose
  5. too inc chemotherapeutic potentiation
43
Q

What is DOT ?

A

directly observed therapy in which supervised therapy is administrated 2/more times each week ., has been advocated as a method of improving adherence and has become particularly important as a means of improving the control of tb in resourse poor nations

44
Q

MDR-TB ?

A

I=8 month
C= 12 MONTH

45
Q

8 MONTH ?

K PLEC

A
  • Kanamycin
  • pyrazinamide
  • lfx
  • ethionamide
  • cycloserine

Monitoring PTB Pt must lagbe 30-12-2024 7.01 PM

Pharmacology-PROF (23 decks)

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