Anti-TB Drugs Flashcards
1
Q
1st line drug of TB ?
A
- isoniazid
- rifampicin
- ethambutol
- pyrizinamide
- rifabutin
- rifapentin
2
Q
2nd line drug ?? TB
A
- levofloxacin
- moxifloxacin
- bedaquiline
- cycloserine
- clofazimine
3
Q
New cases condition ?
A
- bacteriologically + PTB pt
- bacteriologically - PTB pt
- Extra PTB
- TB + HIV coinfected
4
Q
new cases Intensive phase & continuation phase ?/
A
I= 2-HRZE
C=4HR
5
Q
if no resistance to TB drug Tx ?
A
6-HRZE
6
Q
Clinically diagnosed PTB ? Tx /
A
6-HRZE
7
Q
Complicated TB ? Tb meningitis bopne,neuroilogical >?? Tx ?
A
12-HRZE+ Levofloxacin
I=2 HRZELfx
C=10HRZELfx
8
Q
if isoniazid resistant R susceptible in bacteriologically confirmed PTB ?Tx ??
A
6-HRZE-Lfx
9
Q
isoniazid Indication ?
A
- TB
- Latent TB
10
Q
Pyrizinamide & Ethambutol indication ?
A
TB
11
Q
Rifampicin indication ?
A
- TB
- leprosy
- pneumococcal
- streptococcal
- H influenza
- prosthetic valve endocarditis
12
Q
H - A/E ??
A
- hepatitis
- peripheral neuropathy
- N-V
- fever
- skin rashes
- SLE
- convulsion
- hallucination
- memory loss
13
Q
R - A/E ?
A
- Hepatitis
- cholestatic jaundice
- ATN
- proteinuria
- nephritis
- thrombocytopenia
14
Q
In R dx Pt ke ki advice dibo ??
A
Harmless orange/red coloration of saliva urine sweat tears contact lens
15
Q
Z - A/E ??
A
- Hyperuricemia
- N-V
- hepatotoxicity
- photosensitivity’s
16
Q
why Hyperuricemia in Z ?
A
dec- uric acid excretion
17
Q
E - A/E ?
A
- retrobulbar neuritis
- loss of visual acuity
- red green colour blindness
18
Q
hepatotoxic Anti-TB drug ?
A
H-R-Z
19
Q
optic neuritis Tx ?
A
HRZ- 50-75-100
HR-(50-75) Mg
E is given separately as tablet
20
Q
INH full form ?
A
Isonicotinic acid hydrozide
21
Q
Fast acetylation result ?
A
Hepatotoxicity
22
Q
slow acetylation result z?
A
neuropathy
23
Q
Hepatoxicity M/A ?
A
- INH repid aceylators
- more metabolism in liver
- more accumulation of hepatotoxic acetyl hydrazine
24
Q
neuropathy M/A ?
A
- S,low acetylators
- less metabolism in liver - less hepatotoxicity
- less excretion of INH by kidney
- morre plasma conc of INH
- INH promote excretio n of pyridoxine
- pyridoxine deficiency
- peripheral N
25
PN - pt Sign ?
loss of sensations
26
how to avoid PN ?
Vitamin-B6 = Pyridoxine
in a dosage as low as 10mg/day
27
how to avoid heaptotoxicity ?
LFT
if SGPT level is 5times normal = discontinu INH
28
M/A of INH = 1 Line ?
inhibits synthesis of mycolic acid
29
M/A of INH ?
* INH=Prodrug - activated by katG = mycobacterial catalase peroxidase
* INH forms a covalent bond with Acyl caarrier protein(AcpM) + Beta Keto acyl carrier protein(KasA)
* Block mycolic acid synthesis
* cell wall of mycobacterium is disrupted '
* bacterial cell death
30
prominent hepatotoxicity by which drug ?
Z
31
M/A of RIfampicin ?
1. binds with beta subunit of bacterial DNA dependent RNA polymerase
2. inhibit RNA syn thesis
3. no protein synthesis
4. no growth & multiplication
32
enzyme induction which drug ?
Rifampicin
33
R + Wrferin ?
inc thrombosis = thromboembolic disease
34
R + OCP = ?
Unwanted pregnancy
35
R + Anticonvulsants >???
convulsion
36
role of rifampicin as Anti-TB drug ?
1. bactericidal
2. readily penetrates most tissues & into phagocytic cells
3. kill organism that are poorly accesible to many other drugs
4. intracellular + nextracellular
37
Z - M/A ?
* Z taken up by macrophage
* active from of drug - Pyrazinoic acid by mycobacterial pyrazinamidase
38
why 2nd line drug is essential /
1. resistance to 1st line
2. failure to clinical response
3. serious Tx- limiting ADR
4. when expert are available to deal with the toxic effects
39
role of steroid in TB ?
1. Bilateral adrenal TB
2. TB meningitis - pleural effusion - peritonitis -pericarditis - of ureter - renal TB - In AIDS patient
40
which TB drug in chidren /?
Stretomycin
41
why e is not given in children?
optic neuritis
baccha ra bolte parbe na
42
combination of TB drug ? why ?/
1. to broaden the spectrum coverage
2. to prevent development of resistance
3. to shorten duration of action
4. reduce toxic effect of a large dose of a single dose
5. too inc chemotherapeutic potentiation
43
What is DOT ?
directly observed therapy in which supervised therapy is administrated 2/more times each week ., has been advocated as a method of improving adherence and has become particularly important as a means of improving the control of tb in resourse poor nations
44
MDR-TB ?
I=8 month
C= 12 MONTH
45
8 MONTH ?
| K PLEC
* Kanamycin
* pyrazinamide
* lfx
* ethionamide
* cycloserine
| Monitoring PTB Pt must lagbe 30-12-2024 7.01 PM
46
Fixed Dose Combinations - FDC dose ?"
1. I = 75
2. R = 150
3. P = 400
4. E = 275
5. < mg >
47
potency of drug check by which test ??
Gene Xpert
| 820
48
INH makret name ??
RIFAGEN
49
which drug decrease the duration of TB tx ?/
Z
| 815
50
Which aminoglycosides in TBT ??
streptomycin
| 815
51
Why harmless orange / red discolouration in rifampin in ?
Due to colouring excipient
52
Why harmless orange / red discolouration in rifampin in ?
Due to colouring excipient
53
What is XDR-TB ?
😷 What is XDR-TB?
XDR-TB stands for Extensively Drug-Resistant Tuberculosis.
📌 Definition:
XDR-TB is a rare and dangerous form of tuberculosis that is resistant to:
Isoniazid (INH) and Rifampicin (RIF)
→ (Which makes it MDR-TB: Multi-drug-resistant TB)
PLUS
2. Any fluoroquinolone (e.g., levofloxacin, moxifloxacin)
AND
3. At least one second-line injectable drug
like amikacin, kanamycin, or capreomyci
54
MDR-TB ??
resistance to at least H + R
828
55
what is visual acuity ?
loss of near vision
56
children ?
S
57
MDR-TB duration ?
I - 8M
C -12M
58
DOTs full form ?
directly observed therapy
59
meaning of s in DOTs ??
short course
60
Drugs of DOTs ?
ALL TB drugs
\
7.27PM
13.4.2025
61
Optic toxicity ?
Ethambutol
Chloroquine
62
when 2nd line drug ?
MDR TB
63
MDR na thakle kivabe Tx ?
6 month er Tx
64
MDR full form ?
Multi drug resistant TB
