Cell Wall synthesis inhibitors Flashcards

1
Q

Cell wall sy thesis inhibitors name ?

A
  • penicillin
  • cephalosporin
  • cycloserine
  • bacitracin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

natural P ?

A
  1. benzylP /P-G
  2. phenoxyMethylP /P-V
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Semi synthetic P ?

A
  1. Amoxicillin
  2. ampicillin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

narrow spectrum P /

A

P-G & P-V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Broad spectrum P ?

A

A+A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

beta lactamase sensitive ?

A
  1. A
  2. A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Beta lactamase resistant P ?

A
  1. cloxacillin
  2. Di-cloxacillin
  3. flu-cloxacillin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

indication of P-G ?

A
  • sub acute bacterial endocarditis
  • syphillis
  • streptococcal infections
  • gonorrhoea
  • gas gangrene
  • tetanus
  • pneumococcal
  • prophylactic use

SGPT- 3221

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

indication of P-V ?

A
  • streptococcal
  • pneumococcal
  • trench mouth
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

indications of ampicillin ??

A
  • SABE
  • shigellosis
  • gonorrhea
  • RTI
  • neonatal infections
  • acute cholecytitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

indications of amoxicillin ?

A
  • UTI
  • gonorrhoea
  • child infections
  • stretococcal infections
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

M/A of P ?

A

page-758

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

benzathine P is preferred for prophylaxis of RF ??

A
  1. reduce the risk of subsequent acute RF
  2. NO resistance
  3. once monthly dosing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

anti-microbials used in P hypersensitivity?

A
  • macrolides
  • metronidazole
  • vancomycin
  • aztreonam
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Anti-pseudomonal P ??

A
  • carbenicillin
  • azlocillin

757

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Depot P ??

A
  1. P-G + Procaine = 4-5 days
  2. P-G + Benzathine = 26 days
  3. intrathecal = convulsion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what type of action by P ??

A

Bactericidal

758

18
Q

M/A of P ??

758

A
  1. Inhibition of transpeptidase enzyme
  2. binding with PBP
  3. Autolysins

758

19
Q

degradative product of P ??

A

Penicilloic acid `

760

20
Q

anti-staphylococcal p ?

A
  • cloxacillin
  • o-cloxacillin
  • flu-cloxacillin
  • nafcillin
  • oxacillin
21
Q

non-beta lactam bacterial cell wall synthesis inhibitors name ??

A
  • vancomycin
  • cycloserine
  • bacitracine
  • daptomycin
  • Dalba-Tela-Orita-VANCIN
22
Q

Beta lactamase inhibitors >

A

calvulanic acid
sul-bactam
tazo-bactam
avi-bactam
rele-bactam

23
Q

amoxicillin + calvulinic acid = ?????

A

a= destroy by beta-lactamase
but CA inhibit it
so A is prolonged

24
Q

M/A of cephalosporine ?

A

same as P

25
Q

4th genetgeneration C ?

A

Cefepime

26
Q

3rd generation C /

A
  • cefixime
  • ceftriaxone
  • ceftazidime
  • cefotaxime
27
Q

1st G c ?

A

cephradine
cefa-droxil
cefa-zolin

28
Q

2nd G C ?

A

Cefuroxime
cefotetan
cefoxitin
cefaclor

29
Q

A/E of P ?

A
  • HYpersensitivy
  • seizure
  • \N-V-D
  • neutropenia
  • intestinal nephristis
  • hepatitis
30
Q

impenam + cilastatin = ??

A

I = inactivated by dehydropeptidase in renal tubules
Cilastatin = inhibitor of renal dehydropeptidase

773

31
Q

oral C ??

A

1 = cefadroxil
2= cefaclor
3=cefixime

32
Q

5th Generation C ??

A
  • CeftoBiprole
  • CeftaRoline

766

33
Q

anti=pseudomonal C ??

A
  1. Cefepime
  2. ceftazidime
  3. C + azobactum
  4. ceftoLozan + tazobactum

766

34
Q

🤰 category of C ??

A

all safe

766

35
Q

A/E of C ??

A
  1. Allergy - hypersensitivity reaction
  2. cross allergenicity
  3. super infection
  4. bleeding
  5. disulfiram like action
  6. IM= local pain
  7. IV= Thrombophlebitis
  8. N-V-D-Ab pain

/769

36
Q

why C is not given in a pt who is allergic to P ??

A

cross allergenicity

769

37
Q

2nd G C spectrum ??

A
  1. less G +
  2. Moderate G -
  3. PEcK + HEN
  4. H= H influenza E = Enterobacter N = Neisseria

765

37
Q

1st G C spectrum ??

A
  • very active against G +
  • moderate G -
  • = PEcK = Proteus + E coli + Klebsiella
  • resistant to beta lactamase enzyme

765

38
Q

4th G C spectrum&raquo_space;>

A

more resistANT To Beta lactamase

39
Q

3rd G C spectrum ??

A
  • less G +
  • Expamded G -
  • HEN PEcK PSC
  • P= Providencia S = Serratia C = Citobacter

766

40
Q

3rd G C indication ???

A
  • meningitis
  • pneumococci
  • meningococci
  • H influenza
  • salmonella = gonorrheal infection

768

41
Q

4th G C indication ??

A
  • nosocomial infection caused by - Enterobactar + citobacter + serratia

768