Autacoids Flashcards
Anti-histamine classification ?
- physiological antagonists
- H release inhibitors
- H receptor anagonists
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Physiological antagonists of Histamine ?
adrenaline
Indication of physiologic antagonist of hitamine ?
anaphylactic shock
H release inhibitors name ?
- cromolyn
- nedocromil Na
- terbutaline
- salbutamol
H receptor antagonists name ?
- H1
- H2
- H3
- H4
1st generation H1 receptor antagonists name ?
- phenir-amine
- chlor-phenir-amine
- cyclizine
- meclizine
- pyomethazine
- diphenhydramine
2nd generation H1 RECEPTOR antagonits name ?
- fexofenadine
- loratadine
- des-loratadine
- cetririzine
- levo-cetirizine
- cerobastine
- mesolastine
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Anti-histamine effects ??
- inc sedation
- inc appetite
- anti-N
- anti-emetic
- anti-parkinsionian
- dec allergic inflammation
Anti-cholinergic effect of anti-histamine ?
- dried mouth & skin
- urine retention
- blurred vision
- tachycardia
- constipation
anti-adrenergic effects of anti-histamine ?
- postural hypotension
- dizziness
- reflax tachycardia
serotonin blocking action of anti-histamine /
inc appetite
motion sickness indication ?
- promethazine
- diphenhydramine
- cyclizine
- meclizine
Allergic conditions
* itching
* urticaria
* allergic rhinitis
* atopic dermatitis’chronic urticaria
* hay fever - Indications ?
1.. fexofenadine
2. loratadine
3. des-loratadine
4. cetririzine
5. levo-cetirizine
N-V-morning sickness ?
- cyclizine
- meclizine
For sedation ?
promethazine
Parkinson indication ?
diphenhydramine
pre-anesthetic medication which anti-histamine ?
promethazine
LA which anti-histamine ?
- diphenhydramine
- promethazine
A/E of anti-histmine ?
- Anti-adrenergic effect
- anti-cholinergic effects
- CNS-sedation-ataxia-excitation
- allergic dermatitis
commonest A/E of 1st generation?
Sedation
why sedation in 1st geenration ?
- cross BBB
- high lipid soluble
- exert sedative
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effect of H on BP before promethazine ?
h- vasodilation-dec PR- DEC BP
After promethazine - no BP change as H is blocked
Anti-obesity drug name ?
Lor-caserin
5HT-1A agonists name ?
- Bus-Ge-Ipsa-PIRONE
Function of Bupirone ?
non-BZ anxiolytic
5HT-2C agonists name ?
dex-fenfluramine
function of dex-fluramine ?
appetite suppressant
but withdrawn
beacause of toxicity
5HT4 agonists name ?
- cisapride
- tegaserod
5HT-1D/1B agonists name ?
Suma-Niza-Nara-Triptan
which serotonin agonists act as Anti-D ?
- fluxetine
- SSRI
functions of Sumatriptan ?
- acute migraine
- cluster headache
Cisapride function ?
- gastroesophageal reflux
- motility disorder
5HT-1F AGONISTS name ?
lasmaditan
lasmaditan indiaction ?
acute migraine
which drugs inhibit prostaglandin synthesis ?
- NSAID
- corticosteroids
Serotonin antagonists name ?
- 5HT2 RB
- 5HT3 RB
5HT3 RB name ?
- ondan-grani-tropi—SETRON
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5HT3 RB function ?
anti-emetic drugs
cryptoheptadine indication ?
- cold induced urticaria
- carcinoid tumor
- post-gastrectomy dumping syndrome
5HT2 RB name ?
- ketotifen
- ketanserin
- cyproheptadine
ketotifen indication ?
asthma
ketanserin indiaction ?
anti-platelet drug
Medical termination of pregnancy -MTP which drug ?
- misoprostol
- mifepristone
Prostaglandin analogous name ?
- misoprostol -PGE1
- dino-prostone- PGE2
- Alprostadil
- lubi-prostone
- Latano-bimato-travo-PROST
Misoprostol function ?
- induction of abortion & labour
- Tx of PUD & PPH
dinoprostone function ?
- induction of labour
- faciliation of labour
- 2nd trimester abortion
lubiprostone indication ?
IBS + constipation
latano-bimato-travo-prost ?
glaucoma
ecbolics/oxytocics name ?
- oxytocin
- ergot derivatives=ergotamine
- misoprostol
drugs used in induction of labour ?
- misoprostol
- dinoprostol
- oxytocin
- mifepristone
- relaxin
drugs used in PPH ?
- ERGOMETRINE
- OXYTOOXYTOCIN
Tocolytic / anti-oxytotic/ecbolics drugs name ? q
- nifedipine
- indomethacin
- sulindac
- GTN
- terbutaline
- ritodrine
what is tocolytics agent ?
that inhibit uterine contraction
drugs used in acute migraine ?
- suma-nara-riza triptan
- paracetamol
- aspirin
- domperidone
- metoclopramide
- ergotamine
drug of choice for induction of labour ?
oxytocin
danger of ergotamine in 1st stage of labour ??
if E is used before opening of cervix there maybe rupture of uterus , so should never be given before delivery
autacoids name ?
- eicosanoids
- decarboxylated amino acids
- vasoactive peptides
eicosanoids name ?
- prostaglandin
- thromboxans
- leukotriens
PTL
decarboxylated amino acid ?
- H
- S
vasoactive amines name ?
Autacoids defination exam er age porbo inshaallah
- nitric oxide
- substance P
- bradykinin
- angiotensin
- endothelin
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