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Autacoids Flashcards

1
Q

Anti-histamine classification ?

A
  1. physiological antagonists
  2. H release inhibitors
  3. H receptor anagonists

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2
Q

Physiological antagonists of Histamine ?

A

adrenaline

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3
Q

Indication of physiologic antagonist of hitamine ?

A

anaphylactic shock

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4
Q

H release inhibitors name ?

A
  1. cromolyn
  2. nedocromil Na
  3. terbutaline
  4. salbutamol
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5
Q

H receptor antagonists name ?

A
  1. H1
  2. H2
  3. H3
  4. H4
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6
Q

1st generation H1 receptor antagonists name ?

A
  1. phenir-amine
  2. chlor-phenir-amine
  3. cyclizine
  4. meclizine
  5. pyomethazine
  6. diphenhydramine
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7
Q

2nd generation H1 RECEPTOR antagonits name ?

A
  1. fexofenadine
  2. loratadine
  3. des-loratadine
  4. cetririzine
  5. levo-cetirizine
  6. cerobastine
  7. mesolastine

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8
Q

Anti-histamine effects ??

A
  1. inc sedation
  2. inc appetite
  3. anti-N
  4. anti-emetic
  5. anti-parkinsionian
  6. dec allergic inflammation
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9
Q

Anti-cholinergic effect of anti-histamine ?

A
  1. dried mouth & skin
  2. urine retention
  3. blurred vision
  4. tachycardia
  5. constipation
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10
Q

anti-adrenergic effects of anti-histamine ?

A
  1. postural hypotension
  2. dizziness
  3. reflax tachycardia
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11
Q

serotonin blocking action of anti-histamine /

A

inc appetite

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12
Q

motion sickness indication ?

A
  1. promethazine
  2. diphenhydramine
  3. cyclizine
  4. meclizine
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13
Q

Allergic conditions
* itching
* urticaria
* allergic rhinitis
* atopic dermatitis’chronic urticaria
* hay fever - Indications ?

A

1.. fexofenadine
2. loratadine
3. des-loratadine
4. cetririzine
5. levo-cetirizine

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14
Q

N-V-morning sickness ?

A
  1. cyclizine
  2. meclizine
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15
Q

For sedation ?

A

promethazine

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16
Q

Parkinson indication ?

A

diphenhydramine

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17
Q

pre-anesthetic medication which anti-histamine ?

A

promethazine

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18
Q

LA which anti-histamine ?

A
  1. diphenhydramine
  2. promethazine
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19
Q

A/E of anti-histmine ?

A
  1. Anti-adrenergic effect
  2. anti-cholinergic effects
  3. CNS-sedation-ataxia-excitation
  4. allergic dermatitis
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20
Q

commonest A/E of 1st generation?

A

Sedation

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21
Q

why sedation in 1st geenration ?

A
  • cross BBB
  • high lipid soluble
  • exert sedative

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22
Q

effect of H on BP before promethazine ?

A

h- vasodilation-dec PR- DEC BP
After promethazine - no BP change as H is blocked

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23
Q

Anti-obesity drug name ?

A

Lor-caserin

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24
Q

5HT-1A agonists name ?

A
  1. Bus-Ge-Ipsa-PIRONE
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25
Q

Function of Bupirone ?

A

non-BZ anxiolytic

26
Q

5HT-2C agonists name ?

A

dex-fenfluramine

27
Q

function of dex-fluramine ?

A

appetite suppressant
but withdrawn
beacause of toxicity

27
Q

5HT4 agonists name ?

A
  1. cisapride
  2. tegaserod
27
Q

5HT-1D/1B agonists name ?

A

Suma-Niza-Nara-Triptan

28
Q

which serotonin agonists act as Anti-D ?

A
  • fluxetine
  • SSRI
28
Q

functions of Sumatriptan ?

A
  1. acute migraine
  2. cluster headache
28
Q

Cisapride function ?

A
  1. gastroesophageal reflux
  2. motility disorder
29
Q

5HT-1F AGONISTS name ?

A

lasmaditan

30
Q

lasmaditan indiaction ?

A

acute migraine

31
Q

which drugs inhibit prostaglandin synthesis ?

A
  1. NSAID
  2. corticosteroids
32
Q

Serotonin antagonists name ?

A
  1. 5HT2 RB
  2. 5HT3 RB
33
Q

5HT3 RB name ?

A
  1. ondan-grani-tropi—SETRON

695

34
Q

5HT3 RB function ?

A

anti-emetic drugs

35
Q

cryptoheptadine indication ?

A
  1. cold induced urticaria
  2. carcinoid tumor
  3. post-gastrectomy dumping syndrome
36
Q

5HT2 RB name ?

A
  1. ketotifen
  2. ketanserin
  3. cyproheptadine
37
Q

ketotifen indication ?

37
Q

ketanserin indiaction ?

A

anti-platelet drug

38
Q

Medical termination of pregnancy -MTP which drug ?

A
  1. misoprostol
  2. mifepristone
39
Q

Prostaglandin analogous name ?

A
  1. misoprostol -PGE1
  2. dino-prostone- PGE2
  3. Alprostadil
  4. lubi-prostone
  5. Latano-bimato-travo-PROST
40
Q

Misoprostol function ?

A
  • induction of abortion & labour
  • Tx of PUD & PPH
41
Q

dinoprostone function ?

A
  1. induction of labour
  2. faciliation of labour
  3. 2nd trimester abortion
42
Q

lubiprostone indication ?

A

IBS + constipation

43
Q

latano-bimato-travo-prost ?

44
Q

ecbolics/oxytocics name ?

A
  • oxytocin
  • ergot derivatives=ergotamine
  • misoprostol
45
Q

drugs used in induction of labour ?

A
  • misoprostol
  • dinoprostol
  • oxytocin
  • mifepristone
  • relaxin
46
Q

drugs used in PPH ?

A
  • ERGOMETRINE
  • OXYTOOXYTOCIN
47
Q

Tocolytic / anti-oxytotic/ecbolics drugs name ? q

A
  1. nifedipine
  2. indomethacin
  3. sulindac
  4. GTN
  5. terbutaline
  6. ritodrine
48
Q

what is tocolytics agent ?

A

that inhibit uterine contraction

49
Q

drugs used in acute migraine ?

A
  1. suma-nara-riza triptan
  2. paracetamol
  3. aspirin
  4. domperidone
  5. metoclopramide
  6. ergotamine
50
Q

drug of choice for induction of labour ?

51
Q

danger of ergotamine in 1st stage of labour ??

A

if E is used before opening of cervix there maybe rupture of uterus , so should never be given before delivery

52
Q

autacoids name ?

A
  1. eicosanoids
  2. decarboxylated amino acids
  3. vasoactive peptides
53
Q

eicosanoids name ?

A
  1. prostaglandin
  2. thromboxans
  3. leukotriens

PTL

54
Q

decarboxylated amino acid ?

55
Q

vasoactive amines name ?

Autacoids defination exam er age porbo inshaallah

A
  • nitric oxide
  • substance P
  • bradykinin
  • angiotensin
  • endothelin
    *

Pharmacology-PROF (37 decks)

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