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Autacoids Flashcards

1
Q

Anti-histamine classification ?

A
  1. physiological antagonists
  2. H release inhibitors
  3. H receptor anagonists

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2
Q

Physiological antagonists of Histamine ?

A

adrenaline

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3
Q

Indication of physiologic antagonist of hitamine ?

A

anaphylactic shock

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4
Q

H release inhibitors name ?

A
  1. cromolyn
  2. nedocromil Na
  3. terbutaline
  4. salbutamol
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5
Q

H receptor antagonists name ?

A
  1. H1
  2. H2
  3. H3
  4. H4
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6
Q

1st generation H1 receptor antagonists name ?

A
  1. phenir-amine
  2. chlor-phenir-amine
  3. cyclizine
  4. meclizine
  5. pyomethazine
  6. diphenhydramine
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7
Q

2nd generation H1 RECEPTOR antagonits name ?

A
  1. fexofenadine
  2. loratadine
  3. des-loratadine
  4. cetririzine
  5. levo-cetirizine
  6. cerobastine
  7. mesolastine

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8
Q

Anti-histamine effects ??

A
  1. inc sedation
  2. inc appetite
  3. anti-N
  4. anti-emetic
  5. anti-parkinsionian
  6. dec allergic inflammation
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9
Q

Anti-cholinergic effect of anti-histamine ?

A
  1. dried mouth & skin
  2. urine retention
  3. blurred vision
  4. tachycardia
  5. constipation
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10
Q

anti-adrenergic effects of anti-histamine ?

A
  1. postural hypotension
  2. dizziness
  3. reflax tachycardia
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11
Q

serotonin blocking action of anti-histamine /

A

inc appetite

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12
Q

motion sickness indication ?

A
  1. promethazine
  2. diphenhydramine
  3. cyclizine
  4. meclizine
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13
Q

Allergic conditions
* itching
* urticaria
* allergic rhinitis
* atopic dermatitis’chronic urticaria
* hay fever - Indications ?

A

1.. fexofenadine
2. loratadine
3. des-loratadine
4. cetririzine
5. levo-cetirizine

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14
Q

N-V-morning sickness ?

A
  1. cyclizine
  2. meclizine
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15
Q

For sedation ?

A

promethazine

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16
Q

Parkinson indication ?

A

diphenhydramine

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17
Q

pre-anesthetic medication which anti-histamine ?

A

promethazine

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18
Q

LA which anti-histamine ?

A
  1. diphenhydramine
  2. promethazine
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19
Q

A/E of anti-histmine ?

A
  1. Anti-adrenergic effect
  2. anti-cholinergic effects
  3. CNS-sedation-ataxia-excitation
  4. allergic dermatitis
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20
Q

commonest A/E of 1st generation?

A

Sedation

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21
Q

why sedation in 1st geenration ?

A
  • cross BBB
  • high lipid soluble
  • exert sedative

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22
Q

effect of H on BP before promethazine ?

A

h- vasodilation-dec PR- DEC BP
After promethazine - no BP change as H is blocked

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23
Q

Anti-obesity drug name ?

A

Lor-caserin

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24
Q

5HT-1A agonists name ?

A
  1. Bus-Ge-Ipsa-PIRONE
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25
Function of Bupirone ?
non-BZ anxiolytic
26
5HT-2C agonists name ?
dex-fenfluramine
27
function of dex-fluramine ?
appetite suppressant but withdrawn beacause of toxicity
27
5HT4 agonists name ?
1. cisapride 2. tegaserod
27
5HT-1D/1B agonists name ?
Suma-Niza-Nara-Triptan
28
which serotonin agonists act as Anti-D ?
* fluxetine * SSRI
28
functions of Sumatriptan ?
1. acute migraine 2. cluster headache
28
Cisapride function ?
1. gastroesophageal reflux 2. motility disorder
29
5HT-1F AGONISTS name ?
lasmaditan
30
lasmaditan indiaction ?
acute migraine
31
which drugs inhibit prostaglandin synthesis ?
1. NSAID 2. corticosteroids
32
Serotonin antagonists name ?
1. 5HT2 RB 2. 5HT3 RB
33
5HT3 RB name ?
1. ondan-grani-tropi---SETRON | 695
34
5HT3 RB function ?
anti-emetic drugs
35
cryptoheptadine indication ?
1. cold induced urticaria 2. carcinoid tumor 3. post-gastrectomy dumping syndrome
36
5HT2 RB name ?
1. ketotifen 2. ketanserin 3. cyproheptadine
37
ketotifen indication ?
asthma
37
ketanserin indiaction ?
anti-platelet drug
38
Medical termination of pregnancy -MTP which drug ?
1. misoprostol 2. mifepristone
39
Prostaglandin analogous name ?
1. misoprostol -PGE1 2. dino-prostone- PGE2 3. Alprostadil 3. lubi-prostone 4. Latano-bimato-travo-PROST
40
Misoprostol function ?
* induction of abortion & labour * Tx of PUD & PPH
41
dinoprostone function ?
1. induction of labour 2. faciliation of labour 3. 2nd trimester abortion
42
lubiprostone indication ?
IBS + constipation
43
latano-bimato-travo-prost ?
glaucoma
44
ecbolics/oxytocics name ?
* oxytocin * ergot derivatives=ergotamine * misoprostol
45
drugs used in induction of labour ?
* misoprostol * dinoprostol * oxytocin * mifepristone * relaxin
46
drugs used in PPH ?
* ERGOMETRINE * OXYTOOXYTOCIN
47
Tocolytic / anti-oxytotic/ecbolics drugs name ? q
1. nifedipine 2. indomethacin 3. sulindac 4. GTN 5. terbutaline 6. ritodrine
48
what is tocolytics agent ?
that inhibit uterine contraction
49
drugs used in acute migraine ?
1. suma-nara-riza triptan 2. paracetamol 3. aspirin 4. domperidone 5. metoclopramide 6. ergotamine
50
drug of choice for induction of labour ?
oxytocin
51
danger of ergotamine in 1st stage of labour ??
if E is used before opening of cervix there maybe rupture of uterus , so should never be given before delivery
52
autacoids name ?
1. eicosanoids 2. decarboxylated amino acids 3. vasoactive peptides
53
eicosanoids name ?
1. prostaglandin 2. thromboxans 3. leukotriens | PTL
54
decarboxylated amino acid ?
* H * S
55
vasoactive amines name ? | Autacoids defination exam er age porbo inshaallah
* nitric oxide * substance P * bradykinin * angiotensin * endothelin *

Pharmacology-PROF (38 decks)

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