Morphine & Pethidine (Meperidine)

Question 1

Morphine main mechanism ??

Answer 1

Pain transmission is inhibited

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Question 2

Pain associated neurotransmitters ??

Answer 2

1. Substance P
2. Acetylcholine
3. Nor epinephrine
4. Serotonin
5. Glutamate

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Question 2

Morphine another mechanism ??

Answer 2

1. Ophoid receptorninn post synaptic nerve terminal
2. Ophoid receptor - MEU
3. Open K channel
4. Inc k efflux
5. K conductance
6. Hyperpolarization
7. Inhibitory post synaptic potential - IPSP

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Question 2

Ophoid receptor type ??

Answer 2

G protein couple receptor

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Question 3

Moprhine mechanism in your own word ?

Answer 3

1. Morphine binds with ophoid receptors in presynaptic nerve terminal
2. Ophoid receptors - MICRO - DELTA - KAPPA
3. Closure of Ca channel
4. Dec Ca influx
5. Decx relese of neurotransmitter

591

Question 4

Indications of morphine ??

Answer 4

1. Acute MI
2. Severe somatic pain
3. Chronic pain in terminal cancer patient
4. Obstetric labor
5. Acute pulmonary edema
6. Shivering
7. Cough suppression
8. Non infective diarrhea

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Question 5

Effect of Morphine in MI ??

Answer 5

1. Adequate analgesia
2. Lower adrenergic drive
3. Reduce pulmonary vascular resistance ‘
4. Reduce systemic vascular resistance
5. Reduce susceptibility to ventricular arrythmia

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Question 5

CNS Adverse/ effect of mrophine ?

Answer 5

1. Delirium
2. Sedation
3. Myoclonus
4. Seizures

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DM S S

Question 6

Morphine effect in Acute Pulmonary Edema ???

Answer 6

1. Reduced anxiety
2. Reduced Cardiac preload
3. Reduced afterload

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Question 6

Ophoid like anti-Diarrheal drug ??

Answer 6

1. Loperamide
2. Codeine
3. Diphenoxylate

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Question 7

GI A/E of morphine ??

Answer 7

1. Constipation
2. Urinary retention

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Question 8

Respiratory A/E of morphine ??

Answer 8

1. Respiratory depression
2. Nausea / Vomiting

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Question 9

In head injury manifestation of morphine ??

Answer 9

Inc Intracranial Pressure

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