Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacology-PROF > Morphine & Pethidine (Meperidine) > Flashcards

Morphine & Pethidine (Meperidine) Flashcards

1
Q

Morphine main mechanism ??

A

Pain transmission is inhibited

591

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pain associated neurotransmitters ??

A
  1. Substance P
  2. Acetylcholine
  3. Nor epinephrine
  4. Serotonin
  5. Glutamate

591

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Morphine another mechanism ??

A
  1. Ophoid receptorninn post synaptic nerve terminal
  2. Ophoid receptor - MEU
  3. Open K channel
  4. Inc k efflux
  5. K conductance
  6. Hyperpolarization
  7. Inhibitory post synaptic potential - IPSP

591

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Ophoid receptor type ??

A

G protein couple receptor

591

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Moprhine mechanism in your own word ?

A
  1. Morphine binds with ophoid receptors in presynaptic nerve terminal
  2. Ophoid receptors - MICRO - DELTA - KAPPA
  3. Closure of Ca channel
  4. Dec Ca influx
  5. Decx relese of neurotransmitter

591

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Indications of morphine ??

A
  1. Acute MI
  2. Severe somatic pain
  3. Chronic pain in terminal cancer patient
  4. Obstetric labor
  5. Acute pulmonary edema
  6. Shivering
  7. Cough suppression
  8. Non infective diarrhea

593

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Effect of Morphine in MI ??

A
  1. Adequate analgesia
  2. Lower adrenergic drive
  3. Reduce pulmonary vascular resistance ‘
  4. Reduce systemic vascular resistance
  5. Reduce susceptibility to ventricular arrythmia

594

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CNS Adverse/ effect of mrophine ?

A
  1. Delirium
  2. Sedation
  3. Myoclonus
  4. Seizures

594

DM S S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Morphine effect in Acute Pulmonary Edema ???

A
  1. Reduced anxiety
  2. Reduced Cardiac preload
  3. Reduced afterload

594

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Ophoid like anti-Diarrheal drug ??

A
  1. Loperamide
  2. Codeine
  3. Diphenoxylate

595

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

GI A/E of morphine ??

A
  1. Constipation
  2. Urinary retention

594

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Respiratory A/E of morphine ??

A
  1. Respiratory depression
  2. Nausea / Vomiting

594

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

In head injury manifestation of morphine ??

A

Inc Intracranial Pressure

595

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

contraindications of morphine ?

A
  1. head injury
  2. 🤰
  3. impaired -pulmonary-renal - endocrine function
  4. undiagonised acute visceral pain
  5. combining a pure agonist with a weak partial agonist pentazocine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

why pethidine/meperidine&raquo_space;> morphine ?

A
  1. it does not delay labour like morphine
  2. less cardio respiratory depression in fetus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

functional classfication of morphine ?

pure agonist name ?

A
  1. morphine
  2. fenatyl
  3. heroine
  4. oxy & hydro codeine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

partial agonists name ?

A
  1. buprenorphine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

antagonists name ?

A
  1. naloxone
  2. naltrexone
  3. nalmefene
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

moderate agonists name ?

15
Q

according to origin ?

natural ophoid ?

A

morphine
codeine

16
Q

semisynthetic ophoid ?

A

buprenorphone
oxt & dihydrocodeine

17
Q

synthetic ophoid ?

A

pethidine
fenatyl
meperidine
nalbupine
afenatyl
su-fenatyl
remi-fenatyl

18
Q

CNS effects of morphine >?

selective depression of CNS ?

A
  1. Analgesia
  2. sedation
  3. sleep
  4. respirstory depression
  5. cough suppression
  6. hyperthermia
19
Q

selective stimulation of CNS by morphine ?

A
  1. vomiting
  2. miosis
  3. convulsions
  4. hyperactive spinal cord reflexs
20
other CNS effect of Morphine >
dependence changes in mood euphoria dysphoria
21
PNS effect of morphine ?
analgesia
22
other peripheral effects of morphine?
1. CVS-bradycardia + hypotension 2. GIT - constipation 3. renal - urinary retention , dec RBF , anti-diuretics effect 4. uterus - prolong labour 5. neuroendocine - inc release of ADH
23
which ophoid in obstetric labour /
meperidine
24
antitussive drugs ?
1. dextromethorphan 2. codeine
25
which ophoid in shivering ?
1. pethidine
26
endogenous ophoid peptides name ?
1. endorphins 2. dynorphins- A+ B 3. enkephalin
27
Analgesic drugs name /
1. opioid/narcotic 2. non-o/non-n - NSAID
28
What is analgesic drug /
an analgesic is defined as a drug that relieves pain
29
why morphine is restricted drug ?
cause - addiction
30
why contraindicated in impaired respiratory function ?
may cause acute respiratory failure
31
analgesic dose of morphine /
10mg
32
analgesic dose of meperidine
100mg
33
which drugs used as regular analgesic in post operative period ?
1. ketorolac 2. diclofenac 3. naproxane
34
morphine vs pethidine ? | basic 4 ta kotha
1. M= natural 2. late action 3. long duration 4. more potent | pethidine - opposite
35
M VS P? | A/E Diye
1. hypnotic effect 2. respiratory depression 3. cough suppression 4. constipation 5. urinary retensuion
36
histamine realeas by which one ?
morphine = bradycardia + hypotension
37
how to tx a morphine addict ?
1. long term substitutes - methadone + buprenorphine _ heroin 2. b;locking response - naltrexone 3. reducing continued drug use/reducing craving ? - baclofen + ibogaine
38
opioids in which pain type ?
viseral
39
NSAID > pain type ?
somatic
40
which opoids A/E used as indication ?
Diphenoxylate - Constipation anti-emetic drugs 8.51PM 13.4.2025

Pharmacology-PROF (38 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions