Anti-Convulsant/Epileptic+Parkinsonian Drugs

Question 1

physiology of Parkinsonism ??

Answer 1

1. dec dopamine activity 
2. inc cholinergic activity 

641

Question 2

drugs of P that inc dopminergic activity ??

Answer 2

1. levodopa
   bromocriptine
   amantadine

Question 3

drugs that dec cholinergic activity ??

Answer 3

• benhexol
  benztropine
  procyclidine
  orphenadrine
  biperiden

642

Question 4

why L + C

643

Answer 4

🧠 Levodopa + Carbidopa (Sinemet) in Parkinson’s

➡ Levodopa: ⬆ Dopamine in CNS (crosses BBB, converted by DOPA decarboxylase)
➡ Carbidopa: Peripheral DOPA decarboxylase inhibitor (⬇ Peripheral conversion of Levodopa → Dopamine)

🔹 Why mixed?
✔ ⬆ Levodopa bioavailability in CNS (More crosses BBB)
✔ ⬇ Peripheral side effects (N/V, arrhythmias, hypotension)
✔ ⬆ Therapeutic effect (⬇ Required Levodopa dose)

🚨 Long-term issue? “Wearing-off” effect, dyskinesia

Question 5

blokage of Na channel drugs name ??

Answer 5

phenytoin
carbamazepine
valproic acid
Na-valproate

Question 6

blockage of Ca channel ??

Answer 6

valproate
ethosuximide
phen-suximide
meth-suximide
tri-methadione

629

Question 7

which convulsion in children ??

Answer 7

febrile seizure
GTCS
Absence S
Focal S

628

Question 8

GABA a Receptor inhibitor ??

Answer 8

BDZ
Barbiturate s

Question 9

GAT-1 GABA transporter name ??

Answer 9

Tigabine

Question 10

GABA transminase&raquo_space;

Answer 10

Vigabatrin

Question 11

BDZ is given in children in which route ??

Answer 11

IV

629

Question 12

Primary GTCS drug of choice ??

Answer 12

Na-valproate
lamotrigine

630

Question 13

Dx for Absence seizure ??

Answer 13

Na-V
Ethosuximide

630

Question 14

Myclonic Rx ??

Answer 14

Na-V
Clonazepam

Question 15

anti-epileptic role of Na-Valproate ??

Answer 15

1. block voltage gated Na channel = inhibit generation of rapidly repetitive action potential = Anti-epileptic action

2.inc GABA conc in brain = inc GABA mediated CNS depression = Anti-epileptic effect