Prokinetic & Anti-Emetic Drugs Flashcards
Prokinetic drugs name ??
- D2 receptor antagonists
- Cholinomimetic drugs
- Macrolides
- Chloride channels actvator
550
Macrolide drugs name ??
- Erythromycin
- Azithromycin
550
D2 receptor antagonisyts ??
- DomPeridone
- Metoclopramide
550
Cholinomimetic drugs ??
- Bethanochol
- Neostigmine
550
Indications of D22 receptor antagonists ?/
- GERD
- Impaired gastric emptying
- Non ulcer dyspapsia
- Prevent vomiting
- Post partum lactation stimulation
554
CNS effect have which D2 R Antagonists ??
MetoCloPramide
554
A/E of Metoclopramide & domperidone ??
- Headache
- Drowsiness
- Insomnia
- Anxiety
- Agitation
Extrapyrimidal effects of metoclopramide ??
- Dystonia
- Akaathisia
- Parkinsonian features
- Tardive dyskinesia
554
Advantages of domeperidone ??
- Donot cross BBB
- No CNS effects
Elevated prolactin level A/E ??
- Gynecomastia
- Galactorrhea
- Impotence
- Menstrual disorder
554
How to improve the A/E of metoclopramide ??
- Diazepam
- Baclofen
- Promethazine
555
Domperidone block which receptor ??
Dopamine D2 receptor in GIT
553
Mechanism ???
- Block D2 receptor
- No suppression of D mediated Ach release from Myenteric Motor neurons
- Inc Ach from Myenteric ,motor neuron
- Contraction of GI smooth muscle
GI effect by domperidone & metoclopramide ??
- Inc esophageal peristaltic amplitude
- Inc gastric emptying
- Inc Lower esophageal sphincter pressure
- No effect on small I & colonic motility
553
Receptors of Chemoreceptor Trigger Zone ?? CTZ
- D2
- Ophoid receptor
- Muscarinic M1`
4.Histamine H1
551
Serotonin 5HT3 receptor antagonists ??
- Ondan
- Dola
- Grani
- Ramo
SETRON
Clinical uses of Ondansetron ??
- Cchemotherapy induced V & N
- Post operative & post radiational N & V
557
A/E of dolasetron ??
- Prolongation of QT intervel
- headache
- Dizziness
- Constipation
556
Ondansetron effect NO ??
- Prolactin
- Sedation
557
Neurokinin recepto antagonmist ??
- Apre
- FosPre
- Netu
- Rola
PITANT
551
H1 Receptor antagonist ??
- Meclizine
- Cyclizine
- Diphenhydramine
- Dimenhydrinatew
552
Drugs used in irritable bowel syndrome -IBS ??
- Predominant D
- Predominant Constipation
- Chronic Ab pain
- For N Ab pain Bloating
Predominant D in IBS ?
Loperamide
Predominatn Constipation n??
- 5HT4 r agonist - Tegaserode
- Lubiprostone
For N V Bloating & Ab pain in IBS ???
- 5HT3 R Antgonist
SETRON