Prokinetic & Anti-Emetic Drugs

Question 1

Prokinetic drugs name ??

Answer 1

1. D2 receptor antagonists
2. Cholinomimetic drugs
3. Macrolides
4. Chloride channels actvator

550

Question 2

Macrolide drugs name ??

Answer 2

1. Erythromycin
2. Azithromycin

550

Question 3

D2 receptor antagonisyts ??

Answer 3

1. DomPeridone
2. Metoclopramide

550

Question 4

Cholinomimetic drugs ??

Answer 4

1. Bethanochol
2. Neostigmine

550

Question 5

Indications of D22 receptor antagonists ?/

Answer 5

1. GERD
2. Impaired gastric emptying
3. Non ulcer dyspapsia
4. Prevent vomiting
5. Post partum lactation stimulation

554

Question 6

CNS effect have which D2 R Antagonists ??

Answer 6

MetoCloPramide

554

Question 7

A/E of Metoclopramide & domperidone ??

Answer 7

1. Headache
2. Drowsiness
3. Insomnia
4. Anxiety
5. Agitation

Question 8

Extrapyrimidal effects of metoclopramide ??

Answer 8

1. Dystonia
2. Akaathisia
3. Parkinsonian features
4. Tardive dyskinesia

554

Question 9

Advantages of domeperidone ??

Answer 9

1. Donot cross BBB
2. No CNS effects

Question 9

Elevated prolactin level A/E ??

Answer 9

1. Gynecomastia
2. Galactorrhea
3. Impotence
4. Menstrual disorder

554

Question 10

How to improve the A/E of metoclopramide ??

Answer 10

1. Diazepam
2. Baclofen
3. Promethazine

555

Question 11

Domperidone block which receptor ??

Answer 11

Dopamine D2 receptor in GIT

553

Question 12

Mechanism ???

Answer 12

1. Block D2 receptor
2. No suppression of D mediated Ach release from Myenteric Motor neurons
3. Inc Ach from Myenteric ,motor neuron
4. Contraction of GI smooth muscle

Question 13

GI effect by domperidone & metoclopramide ??

Answer 13

1. Inc esophageal peristaltic amplitude
2. Inc gastric emptying
3. Inc Lower esophageal sphincter pressure
4. No effect on small I & colonic motility

553

Question 14

Receptors of Chemoreceptor Trigger Zone ?? CTZ

Answer 14

1. D2
2. Ophoid receptor
3. Muscarinic M1`
   4.Histamine H1

551

Question 15

Serotonin 5HT3 receptor antagonists ??

Answer 15

1. Ondan
2. Dola
3. Grani
4. Ramo

SETRON

Question 16

Clinical uses of Ondansetron ??

Answer 16

1. Cchemotherapy induced V & N
2. Post operative & post radiational N & V

557

Question 17

A/E of dolasetron ??

Answer 17

1. Prolongation of QT intervel
2. headache
3. Dizziness
4. Constipation

556

Question 18

Ondansetron effect NO ??

Answer 18

1. Prolactin
2. Sedation

557

Question 19

Neurokinin recepto antagonmist ??

Answer 19

1. Apre
2. FosPre
3. Netu
4. Rola

PITANT

551

Question 20

H1 Receptor antagonist ??

Answer 20

1. Meclizine
2. Cyclizine
3. Diphenhydramine
4. Dimenhydrinatew

552

Question 21

Drugs used in irritable bowel syndrome -IBS ??

Answer 21

1. Predominant D
2. Predominant Constipation
3. Chronic Ab pain
4. For N Ab pain Bloating

Question 22

Predominant D in IBS ?

Answer 22

Loperamide

Question 22

Predominatn Constipation n??

Answer 22

1. 5HT4 r agonist - Tegaserode
2. Lubiprostone

Question 23

For N V Bloating & Ab pain in IBS ???

Answer 23

1. 5HT3 R Antgonist

SETRON