Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology-PROF > Diarrhea & AntiDiarrheal Drugs > Flashcards

Diarrhea & AntiDiarrheal Drugs Flashcards

1
Q

Oral Rehydration Solution ???

A

Oral Rehydration Salt + Adequate water = ORS

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Different types of ORS ??`

A
  1. Citrate saline
  2. Bicarbonate saline
  3. Rice saline

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Trisodium Citrate Dihydrate in ORS ?

A

2.9gm/L

according to lecture slide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

NaCl in ORS ?/

A

2.6 gm/L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

KCl in ORS ??

A

1.5 gm/L

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dehydration consequences?

A
  1. Shock
  2. Hypovolemia
  3. Renal failure

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Anhydrous glucose in ORS ?/

A

13.5gm/L

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Water of the ORS function ??

A

Corrects fluid loss
Dehydration

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

NaCl & KCl function ??

A
  1. Correct electrolyte loss
  2. Maintain electrolyte balance

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Citrate function of ORS >??

Trisodium Citrate dehydrate - 2.5gm/L

A
  1. inc absoprtion of Na+ & Glucose
  2. dec stool output

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

HCO3- Bicarbonate function ?/

A

Correct the acidosis

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Glucose function of ORS ??

A

Na+ absorption by Na+ Glucose Co-Transporter

559

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Opioid agonists name ??

AntiMotillity drugs name

A
  1. Codeine
  2. Loperamide
  3. Diphenoxylate

560

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

A/E of antimotility drugs ??

A
  1. Sequestration of fluid in the intestine
  2. Shock without any diarrhea
  3. Toxic megacolon
  4. Abdominal distension
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Indiscriminate use of antimotility drugs ??

A
  1. Antimotility drugs reduce gastric motility - thats why used in diarrhea

560`

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Contraindication of antimotility drugs&raquo_space;??

A

Should not be used in young childrens and pts with severe colitis

560

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Criticize indiscriminate use of antimicrobials in acute diarrhea ??

A

D caused by Virus Toxins Drugs – NO need of antibiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Antibiotics in D when ??

A

Only if D is caused by Bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Indication of antibiotics ??

A
  1. Diagnosed case of cholera
  2. Dysentry
  3. Systemic manifestation of endotoxic shock
  4. Presence of fecal leukocytes (pus cells ) for more than 10/HPF

561

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Tx of infective diarrhea ??

A
  1. Correction of dehydration
  2. Correction of electrolyte balance
  3. Use appropriate antibiotics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Shigella – D - Drugs of 1st choice ?

A

Quinolones

561

19
Q

E coli – D – Drugs ??

A
  1. Cephalosporin
  2. TMP-SMZ

561

20
Q

Complylobacter jejuni - D– Drugs ??

A
  1. Arithromycin
  2. Erythromycin

561

21
Q

v cholerae ?

A

tetracycline
ciprofloxacin

22
Q

Shigella te P drugs ?

A

Ciprofloxacin

23
Q

Anti-ulcernat drugs ?

A

531

sucralfate
misoprostol
colloidal bismuth compund s

24
Q

PPI is taken before or after meal ?

A

before meal

25
Q

why PPI before meal ?

A

block H/K atpase which are most active post-meal
best absoprtion
empty stomach - inc bioavailabilut

26
Q

which PPI can be taken anytime >

A

dexlansoprazole
dual release

27
Q

misoprostol GI function ?

27
Q

which H2 blocker still in use >

A

famotidine

28
Q

other than PUD misoprostol function >

A

induction of labour
faciliation of labour
Tx of PPH
Tx of PUD

29
Q

Pregnancy safe H2 ?

A

ranitidine
famotidine

29
Q

preganancy te kon H1 antiemetic

A

cyclizine
promethazine

30
Q

systemic antacid name ?

A

CaCO3
ALOH3
MgOH3
Mg - trisilicate

31
Q

A/E of antacids ?

A

metabolic alkalosis
belching
constipation
osmotic disarrhea
milk alkali syndorme
renal insufficiency
hypercalcemia

32
Q

anti-emetic drug

33
Q

cytoprotection which drugs ?

A

same as anti-ulcerant

34
Q

Severe D te ki korba ?

A

IV cholera saline

35
Q

Severe D te ORS diba na ???

A

NO
pt cannot take that orally

36
Q

NSAID induce ulcer which one >

A

PPI
munni mam

37
Q

which other drug cause ulcer /.

38
Q

which drug is used in steroid-induced ulcer <

A

PPI
misoprostol

39
Q

steroids + NSAID == ??/

A

high risk
prophylaxis with PPI

40
Q

BD te ORS e H2O koto ?

A

500 C C
2 powa

41
Q

WHO -ORS water ?

42
Q

how loperamide act on Diarrhea >

A

Loperamide acts primarily by binding to opioid receptors in the gastrointestinal tract, inhibiting the release of acetylcholine and prostaglandins. This reduces peristalsis and intestinal secretion, increasing intestinal transit time and allowing for greater absorption of water and electrolytes, thereby alleviating diarrhea. (Source: Katzung & Trevor’s Pharmacology)

inc colonic transit time
inc fecal water absoprtion
dec mass colonic movement ‘
loperamide have anti-secretory action againts cholera toxin

43
Q

should we use loperamide in D <

A

yeah
560
not cross BBB
no analgesic
more potent
no addiction

44
Q

kader loepramide dibo ?

45
Q

M/A of antacid ?

46
Q

domeperidone vs metoclopramide

47
Q

loperamide kader jonno contraindications?

A

pt with IBD
as they may develop paralytic ileus toxic megacolon

Pharmacology-PROF (37 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions