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Pharmacology > Diarrhea & AntiDiarrheal Drugs > Flashcards

Diarrhea & AntiDiarrheal Drugs Flashcards

1
Q

Oral Rehydration Solution ???

A

Oral Rehydration Salt + Adequate water = ORS

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2
Q

Different types of ORS ??`

A
  1. Citrate saline
  2. Bicarbonate saline
  3. Rice saline

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3
Q

Trisodium Citrate Dihydrate in ORS ?

A

2.9gm/L

according to lecture slide

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4
Q

NaCl in ORS ?/

A

2.6 gm/L

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5
Q

KCl in ORS ??

A

1.5 gm/L

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6
Q

Dehydration consequences?

A
  1. Shock
  2. Hypovolemia
  3. Renal failure

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6
Q

Anhydrous glucose in ORS ?/

A

13.5gm/L

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7
Q

Water of the ORS function ??

A

Corrects fluid loss
Dehydration

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8
Q

NaCl & KCl function ??

A
  1. Correct electrolyte loss
  2. Maintain electrolyte balance

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9
Q

Citrate function of ORS >??

Trisodium Citrate dehydrate - 2.5gm/L

A
  1. inc absoprtion of Na+ & Glucose
  2. dec stool output

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9
Q

HCO3- Bicarbonate function ?/

A

Correct the acidosis

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10
Q

Glucose function of ORS ??

A

Na+ absorption by Na+ Glucose Co-Transporter

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11
Q

Opioid agonists name ??

AntiMotillity drugs name

A
  1. Codeine
  2. Loperamide
  3. Diphenoxylate

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12
Q

A/E of antimotility drugs ??

A
  1. Sequestration of fluid in the intestine
  2. Shock without any diarrhea
  3. Toxic megacolon
  4. Abdominal distension
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12
Q

Indiscriminate use of antimotility drugs ??

A
  1. Antimotility drugs reduce gastric motility - thats why used in diarrhea

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13
Q

Contraindication of antimotility drugs&raquo_space;??

A

Should not be used in young childrens and pts with severe colitis

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14
Q

Criticize indiscriminate use of antimicrobials in acute diarrhea ??

A

D caused by Virus Toxins Drugs – NO need of antibiotics

15
Q

Antibiotics in D when ??

A

Only if D is caused by Bacteria

16
Q

Indication of antibiotics ??

A
  1. Diagnosed case of cholera
  2. Dysentry
  3. Systemic manifestation of endotoxic shock
  4. Presence of fecal leukocytes (pus cells ) for more than 10/HPF

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17
Q

Tx of infective diarrhea ??

A
  1. Correction of dehydration
  2. Correction of electrolyte balance
  3. Use appropriate antibiotics
18
Q

Shigella – D - Drugs of 1st choice ?

A

Quinolones

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19
Q

E coli – D – Drugs ??

A
  1. Cephalosporin
  2. TMP-SMZ

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20
Q

Complylobacter jejuni - D– Drugs ??

A
  1. Arithromycin
  2. Erythromycin

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21
Q
A

Pharmacology (16 decks)

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