Pathoma: Plasma Cell Disorders and Histiocytosis Flashcards
1
Q
What cytokine is often elevated in patients with plasma cell myeloma?
A
IL-6
2
Q
Why do those with plasma cell myeloma get bone lesions?
A
Plasma cells activate ostoclast activating factor, which punches out bone.
3
Q
Explain the pathophysiology of Waldenstrom macroglobulinemia.
A
It is a B cell lymphoma with a monoclonal IgM production; patients have LAD, bleeding (due to the viscosity of the blood impairing clotting), and neurologic effects; no lytic bone lesions,
4
Q
How is Waldenstrom’s macroglobulinemia treated?
A
Plasmapheresis
5
Q
What histologic finding is characteristic of Langerhan cell histiocytosis?
A
Birbeck’s granulocytes (the tennis-racket sign)
