Pathoma: Cervix Flashcards
The __________ is lined with stratified squamous epithelium, while the ___________ is lined with pseudostratified columnar epithelium.
exocervix; endocervix
HPV infects the ___________.
transformation zone (between the endocervix and exocervix)
E6 disrupts ____________, and E7 disrupts __________.
p53; RB
If there is too much DNA damage, then p53 activates _______.
BAX to induce apoptosis
What is the key differentiating feature between dysplasia and carcinoma?
Dysplasia is reversible, and carcinoma is not
CIN I regresses about 66% of the time. CIN II regresses about 33% of the time. CIN III rarely reverses.
What’s the difference between CIN III and CIS?
CIN III takes up most of the epithelium, but it is reversible.
What are the two cancers that smoking causes that kind of don’t make sense?
Pancreatic and cervical
In addition to smoking, ______________ also raises likelihood of developing cervical carcinoma.
immunosuppression (it is actually an AIDS-defining illness)
Advanced cervical cancer often causes death by ______________.
post-renal kidney failure due to invasion into the bladder
Is Pap smear a successful screening tool?
Yes! It is the most successful cancer screening tool to date.
Abnormal Pap tests should be followed up by ___________.
colposcopy
Pap screens for ___________ are less effective.
adenocarcinoma
