Pathoma: Chronic Leukemia

Question 1

Chronic leukemias result in high ______ counts.

Answer 1

WBC

Question 2

CLL is a neoplastic proliferation of naive ______ cells, which express _____.

Answer 2

B; CD5 (normally seen only in T cells) and CD20

Question 3

Complications of CLL include ______.

Answer 3

hypogammaglobulinemia, autoimmune hemolytic anemia, and transformation to DLBCL (indicated by an enlarged lymph node or spleen)

Question 4

Hairy cell leukemia is a neoplastic proliferation of _________.

Answer 4

mature B cells

Question 5

HCL cells will express ________.

Answer 5

tartrate-resistant acid phosphatase (TRAP)

Question 6

Uniquely, in HCL there is no __________.

Answer 6

lymphadenopathy

Question 7

HCL has an excellent response to _______.

Answer 7

2-CDA, an adenosine deaminase

Question 8

ATLL (adult T-cell leukemia lymphoma) cells express _______.

Answer 8

CD4

Question 9

ATLL usually produces a ______ in the patient.

Answer 9

rash and lytic bone lesions with hypercalcemia