Pathoma: Other Disorders of Hemostasis Flashcards

1
Q

Heparin can form a complex with the ______ on platelets.

A

platelet-factor 4

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2
Q

Patients clot in heparin-induced thrombocytopenia because __________.

A

the antibody-attacked platelets fragment and shoot out pieces of their granules into the bloodstream

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3
Q

Bleeding from an IV site is a classic sign of _________.

A

disseminated-intravascular coagulation

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4
Q

What can cause DIC?

A

Obstetric complication (amniotic emboli), sepsis, adenocarcinoma (the mucus from the carcinoma can activate platelets), APML, and rattlesnake bites

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5
Q

Lab signs of DIC are _________.

A

thrombocytopenia, increased PT/PTT (with PTT than PT), decreased fibrinogen, microangiopathic hemolytic anemia, elevated D-dimers

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6
Q

Plasmin cleaves both ___________.

A

polymerized fibrin and serum fibrinogen

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7
Q

What can cause excess plasmin activity?

A

Radical prostatectomy (which causes release of urokinase) and cirrhosis of the liver (which will cause failure to release alpha-2-antiplasmin)

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8
Q

Why will you not see D-dimers in radical prostatectomy or liver cirrhosis?

A

Because there is not excess clotting (as there is in DIC)

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