Pathoma: Other Disorders of Hemostasis

Question 1

Heparin can form a complex with the ______ on platelets.

Answer 1

platelet-factor 4

Question 2

Patients clot in heparin-induced thrombocytopenia because __________.

Answer 2

the antibody-attacked platelets fragment and shoot out pieces of their granules into the bloodstream

Question 3

Bleeding from an IV site is a classic sign of _________.

Answer 3

disseminated-intravascular coagulation

Question 4

What can cause DIC?

Answer 4

Obstetric complication (amniotic emboli), sepsis, adenocarcinoma (the mucus from the carcinoma can activate platelets), APML, and rattlesnake bites

Question 5

Lab signs of DIC are _________.

Answer 5

thrombocytopenia, increased PT/PTT (with PTT than PT), decreased fibrinogen, microangiopathic hemolytic anemia, elevated D-dimers

Question 6

Plasmin cleaves both ___________.

Answer 6

polymerized fibrin and serum fibrinogen

Question 7

What can cause excess plasmin activity?

Answer 7

Radical prostatectomy (which causes release of urokinase) and cirrhosis of the liver (which will cause failure to release alpha-2-antiplasmin)

Question 8

Why will you not see D-dimers in radical prostatectomy or liver cirrhosis?

Answer 8

Because there is not excess clotting (as there is in DIC)