Pathoma: CNS Tumors Flashcards

1
Q

Where do metastatic lesions develop in the brain?

A

At the gray-white junction

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2
Q

What cells make up the meninges?

A

Meningothelial cells

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3
Q

What are the most common primary CNS tumors in kids and adults?

A

Kids: pilocytic astrocytoma
Adults: glioblastoma multiforme

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4
Q

A tumor without IDH mutations and with PTEN mutations commonly crosses the ____________.

A

corpus callosum (this is glioblastoma multiforme)

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5
Q

What does palisading mean?

A

Lining up

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6
Q

What type of protein is GFAP?

A

An intermediate filament

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7
Q

Meningiomas are neoplasms of which layer?

A

The arachnoid

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8
Q

Why does meninioma occur more often in females?

A

Because meningiomas express estrogen receptors

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9
Q

What molecule do Schwannomas display?

A

S100

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10
Q

Where do oligodendrogliomas typically present?

A

In the frontal lobe as a seizure-causing, calcified mass

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11
Q

How are the rosettes in ependymoma different from medulloblastoma?

A

The ependymal rosettes line blood vessels

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12
Q

Explain the unusual embryology of the pituitary gland.

A

The anterior part arises from a pouch in the pharynx while the posterior part arises from the brain.

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13
Q

Bitemporal hemianopsia in a child suggests ____________.

A

craniopharyngioma (pressing on the optic chiasma – pituitary tumors more common in adults)

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