Pathoma: Liver (Hepatitis)

Question 1

Other than the hepatitis viruses, what other viruses can cause inflammation of the liver parenchyma?

Answer 1

EBV and CMV

Question 2

What bilirubin pattern is seen in those with acute viral hepatitis?

Answer 2

Elevated direct (because of inflammation blocking ductules) and elevated indirect (because of inflammation destroying hepatocytes)

Question 3

The symptoms of acute hepatitis usually last less than ____________.

Answer 3

six months

Question 4

What transaminase pattern is seen in those with acute hepatitis?

Answer 4

ALT greater than AST (because the ALT is specific to the liver)

Question 5

Describe the areas of the liver that are usually affected by acute and chronic hepatitis.

Answer 5

Acute: lobular

Chronic: portal

Question 6

HEV is classically acquired from _______________.

Answer 6

undercooked seafood or tainted water

Question 7

Infection with HEV in ___________ can lead to fulminant liver necrosis.

Answer 7

pregnant women (“it’s scarEE to get HEEEV if you’re having a babEEEEE”)

Question 8

Hepatitis B only rarely develops into ____________.

Answer 8

chronic disease (20%)

Question 9

Presence of IgG against HBV surface antigen indicates _________________.

Answer 9

that you have been immunized to HBV or you have successfully resolved HBV

Question 10

Presence of HBeAg (envelope antigen) or HBV DNA indicates ___________.

Answer 10

infectivity (because the envelope indicates that the virus has been packaged and is ready to be shipped out)

Question 11

What is the rule about HBV and HDV severity?

Answer 11

Imposing an HDV infection on top of an existing HBV infection is worse than being infected with both at the same time.