Other miscellaneous markers

Question 1

Diagnostic significance of 5’-nucleotidase

Answer 1

Intrahepatic cholestasis; identifies source of increased ALP

Question 2

Major sources of acid phosphatase

Answer 2

Prostate, RBCs

Question 3

Significance of acid phosphatase

Answer 3

Prostatic carcinoma, hyperplasia, forensic chemistry (rape)

Question 4

Substrate for Roy method for ACP

Answer 4

Thymolphthalein monophosphate

Question 5

Chemical inhibitor of prostate ACP

Answer 5

Tartrate

Question 6

Chemical inhibitor of RBC ACP

Answer 6

Copper formaldehyde

Question 7

Formula for prostatic ACP

Answer 7

Total ACP – ACP after tartrate inhibition

Question 8

Clinical significance of aldolase

Answer 8

Skeletal muscle disorders

Question 9

Clinical significance of glutamate dehydrogenase

Answer 9

Hepatocellular disorders

Question 10

Clinical significance of glutathione-S-transferase

Answer 10

Hepatocellular disorders

Question 11

Enzymes associated with hepatocellular disorders

Answer 11

Glutathione-S-transferase, MDH

Question 12

Function of ACE

Answer 12

Regulation of blood pressure

Question 13

Clinical significance of glycogen phosphorylase

Answer 13

Acute myocardial infarction (AMI)

Question 14

Enzymes for pancreatic insufficiency

Answer 14

Trypsin, Chymotrypsin, Elastase 1

Question 15

Deficiency of G6PD causes

Answer 15

Decreased RBCs, drug-induced hemolytic anemia

Question 16

Deficiency of pyruvate kinase causes

Answer 16

Echinocytes, decreased RBCs, hemolytic anemia, secondary membrane abnormality

Question 17

Clinical significance of pseudocholinesterase

Answer 17

Pesticide poisoning (organophosphates, carbamates), liver diseases, genetic variants

Question 18

Effect of pseudocholinesterase genetic variants

Answer 18

Prolonged response to muscle relaxants (ABN variants)