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Clinical Chemistry > Bilirubin formation > Flashcards

Bilirubin formation Flashcards

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1
Q

Time when RBC are phagocytized in Reticuloendothelial System

A

Approximately 126 days

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2
Q

Degradation product of hemoglobin

A

Globin (recycled in liver) and heme

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3
Q

Action of heme after release of iron

A

Binds with transferrin to be transported to liver

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4
Q

Heme conversion through Heme Oxygenase

A

Heme → biliverdin

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5
Q

Biliverdin conversion through Biliverdin Reductase

A

Biliverdin → unconjugated bilirubin (B1)

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6
Q

Transport form of unconjugated bilirubin (B1) in plasma

A

B1 binds with albumin

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7
Q

Action of albumin in hepatocytes

A

Albumin detaches on the surface of hepatocytes

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8
Q

Transport of B1 to the liver

A

B1 binds to ligandin to enter the SER

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9
Q

Conjugation of B1 in the liver

A

B1 undergoes esterification and conjugation

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10
Q

Enzyme catalyzing B1 conjugation

A

Uridine Diphosphate Glucuronyl Transferase (UDPGT)

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11
Q

Conversion of B1 to B2

A

UDPGT converts B1 to Bilirubin diglucuronide (B2)

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12
Q

Action of UDPGT

A

Promotes transfer of glucuronyl/glucuronide to each of bilirubin’s two propionic side chains

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13
Q

Excretion of B2 from hepatocytes

A

B2 is excreted through bile canaliculi

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14
Q

Storage of B2 in the liver

A

B2 is transported to the gall bladder for storage

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15
Q

Action of bile during meals

A

Bile emulsifies fats in the small intestine

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16
Q

Conversion of B2 in the large intestine

A

Normal flora acts on B2 → mesobilirubin

17
Q

Further reduction of mesobilirubin

A

Mesobilirubin → mesobilirubinogen → urobilinogen (colorless)

18
Q

Fate of 80% of urobilinogen

A

Oxidized to urobilin/stercobilin (yellow-brown stool pigment)

19
Q

Fate of 20% of urobilinogen

A

Reabsorbed, recycled through liver, and reexcreted

20
Q

Fate of small amount of 20% urobilinogen

A

Filtered by kidneys and excreted in urine

21
Q

Effect of bilirubin metabolism problems

A

Changes in urine and stool appearance

22
Q

Plasma B2 increase effect

A

Evident changes in urine

Clinical Chemistry (35 decks)

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