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Clinical Chemistry > NPN URIC ACID and Ammonia > Flashcards

NPN URIC ACID and Ammonia Flashcards

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1
Q

What is produced from the catabolism of purines in nucleic acids?

A

Uric acid

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2
Q

At what concentration can uric acid be deposited in joints and tissues?

A

> 6.8mg/dL

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3
Q

What chemical method detects uric acid?

A

Phosphotungstic Acid Method

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4
Q

Which reagent is used in the chemical method for uric acid detection?

A

H3PW12O40

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5
Q

What is the product of the chemical method for uric acid detection?

A

Allantoin + tungsten (tungsten blue)

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6
Q

What is the key enzyme in the uricase method for uric acid detection?

A

Uricase

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7
Q

At what wavelength is uric acid absorbance measured in the enzymatic method?

A

293nm

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8
Q

What is the main interference in uric acid detection?

A

Ascorbic acid

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9
Q

What is the reference range for uric acid in males?

A

3.5-7.2 mg/dL

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10
Q

What is the reference range for uric acid in females?

A

2.6–6.0 mg/dL

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11
Q

Which condition is associated with hyperuricemia?

A

Gout

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12
Q

Which syndrome is linked to hyperuricemia?

A

Lesch-Nyhan syndrome

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13
Q

What condition is associated with hypouricemia?

A

Fanconi syndrome

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14
Q

Which drug is associated with hypouricemia?

A

Allopurinol

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15
Q

Ammonia is produced from?

A

Catabolism of amino acids

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16
Q

Ammonia is metabolized in?

A

Liver

17
Q

Cycle involved in ammonia metabolism?

A

Krebs-Henseleit or urea cycle

18
Q

Reference range for ammonia?

A

19-60 µg/dL

19
Q

Hyperammonemia associated with?

A

Hepatic failure

20
Q

Liver condition linked to high ammonia?

A

Hepatic cirrhosis

21
Q

Syndrome associated with hyperammonemia?

A

Reye Syndrome

22
Q

Defect causing increased ammonia?

A

Urea cycle defect

23
Q

Potentiometric method for ammonia detection?

A

pH change as NH3 diffuses

24
Q

Colorimetric method for ammonia detection?

A

NH3 + bromphenol blue → blue dye

25
Q

Enzyme method for ammonia detection?

A

GLDH Method

26
Q

Product of GLDH Method for ammonia?

A

Glutamate + NAD

27
Q

Effect of increased ammonia on brain?

A

Increased BBB, coma

28
Q

Ammonia collected in?

A

Heparinized tubes

29
Q

Ammonia samples transported on?

A

Ice

Clinical Chemistry (35 decks)

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