Important Electrolytes Flashcards
Major extracellular cation
Sodium
Renal threshold for sodium
110-130 mmol/L (120 mmol/L)
Reference range for sodium
136–145 mmol/L (mEq/L)
Panic values for sodium
</= 120 mmol/L (hyponatremia), >/= 160 mmol/L (hypernatremia)
Most common method for sodium measurement
Ion-selective electrode (ISE) with glass silicate electrode
Difference between direct and indirect ISE
Direct measures undiluted, indirect measures diluted (prone to pseudohyponatremia)
Color observed in flame photometry for sodium
Yellow
Rarely used colorimetric method for sodium
Albanese-Lein (produces yellow color)
Causes of absolute sodium loss in hyponatremia
Addison’s disease, salt-losing nephropathy, ketonuria, prolonged vomiting or diarrhea, severe burns, diuretics
Cause of dilutional hyponatremia with water retention
Renal failure, CHF, nephrotic syndrome, hepatic cirrhosis
Condition causing water imbalance in hyponatremia
SIADH, increased water intake
Effect of SIADH on sodium and water
Increased ADH retention, relative water excess, pseudohyponatremia
Causes of high plasma osmolality in hyponatremia
Hyperglycemia, mannitol infusion
Causes of hypernatremia with absolute sodium increase
NaHCO3 excess, hyperaldosteronism (Conn’s syndrome)
Urine osmolality < 300 mOsm/kg in hypernatremia
Diabetes insipidus (low urine SG and Osm)
Urine osmolality 300–700 mOsm/kg in hypernatremia
Partial AVP defect, osmotic diuresis
Urine osmolality > 700 mOsm/kg in hypernatremia
Loss of thirst, insensible water loss, GI fluid loss, excess sodium intake
Direct ISE measures sodium in
Undiluted samples
Indirect ISE measures sodium in
Diluted samples (prone to pseudohyponatremia)
Causes of absolute sodium loss in hyponatremia
Addison’s disease, salt-losing nephropathy, ketonuria (DKA), prolonged vomiting or diarrhea, severe burns, diuretics
Pathophysiology of sodium loss in Addison’s disease
Primary adrenalism; decreased aldosterone leads to reduced sodium retention and increased potassium
Causes of dilutional hyponatremia due to water retention
Renal failure, CHF, nephrotic syndrome, hepatic cirrhosis
Causes of dilutional hyponatremia due to water imbalance
Increased water intake, SIADH
Mechanism of SIADH in hyponatremia
Increased ADH retention caused by tumors; hydrostatic pressure exceeds osmotic pressure, leading to pseudohyponatremia