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M3 > Onco: Principles of Treatment > Flashcards

Onco: Principles of Treatment Flashcards

1
Q

Indications for use of GCSF (Preventive)

a. Administration of GCSF is routine with the first cycle of chemotherapy
b. Use if the probability of febrile neutropenia >=20%
c. Use if patient has good performace status
d. Use for age >60 years treated for lymphoma with curative intent
e. AOTA

A

B.

A is wrong. not needed on a routine basis
C. use of patient has poor performance status
D.Age >65 years treated for lymphoma with curative intent

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2
Q

True of secondary CSF administration

a. Done with subsequent cycles if febrile neutropenia has previously occurred
b. Not needed after short-duration neutropenia without fever
c. Use if prolonged neutropenia delays therapy
d. AOTA
e. NOTA

A

D

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3
Q

True of CSF administration for therapeutic uses

a. There is strong evidence of benefit for administration of CSF in afebrile neutropenic patients
b. There is no evidence of benefit in giving CSF for febrile neutropenic patients.
c. it is safe to give GMCSF in AML
d. AOTA

A

B.

A is wrong, no strong evidence of benefit
C is wrong, it may cause harm

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4
Q

T/F all cancers present as tumors

A

F; how about leukemia?

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5
Q

syndrome of Tumor presentation owing to the effects of substances they secrete is called

A

Paraneoplastic syndrome

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6
Q

Establishing cancer diagnosis is usually accomplished by this procedure

A

biopsy

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7
Q

Entire tumor mass is removed with a small margin of normal tissue surrounding it, and subsequent pathologic studies.

A

Excisional biopsy

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8
Q

Wedge of tissue is removed and an effort is made to include the majority of the cross-sectional diameter of the tumor in the biopsy to minimize sampling error. This procedure is called

A

Incisional biopsy

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9
Q

Excisional biopsy, if possible, is preferred over incisional biopsy. T/F

A

T

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10
Q

c-kit oncoprotein mutation

a. Breast Cancer
b. Colon cancer
c. melanoma
d. GI stromal tumor

A

D

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11
Q

Ki-ras mutation

a. Breast CA
b. brain tumor
c. Leukemia
d. Colon cancer

A

D

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12
Q

Bcr-Abl fusion protein

a. Lymphoma
b. Leukemia
c. Lung cancer
d. brain cancer

A

B

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13
Q

Alk oncoprotein gene fusion

a. breast cancer
b. lung cancer
c. melanoma
d. brain tumor

A

B

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14
Q

c-kit expression and mutation

a. GI stromal tumor
b. melanoma
c. leukemia
d. lymphoma

A

B; GI tumor is c-kit oncoprotein mutation

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15
Q

CD30 immunohistochemistry

a. leukemia
b. lymphoma
c. colon cancer
d. ovarian cancer

A

B

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16
Q

This biopsy procedure obtains only a suspension of cells from within a mass

A

fine needle aspiration

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17
Q

This biopsy procedure obtains considerably less tissue, but often provides information to plan a definitive surgical procedure

A

Core-needle biopsy

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18
Q

T/F it’s safe to say that it’s not cancer when fine needle aspiration is negative

A

F

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19
Q

What is the primary goal of cancer treatment

a. palliation
b. tumor reduction
c. improve quality of life
d. cure

A

D

20
Q

Two main types of cancer treatment

A
  1. local

2. systemic

21
Q

Examples of local cancer treatment

A

surgery

radiation

22
Q

Examples of systemic treatments

A

chemotherapy

biologics

23
Q

What do you call cancer growth curve pattern?

A

Gompertzian growth curve

24
Q

What is the most effective means of treating cancer?

A

Surgery

25
Q

Percentage of cancer patients cured by surgery today

A

40%

26
Q

What do you call the type of resection where the tumor is completely excised with an adequate margin of normal tissue, touching the tumor as little as possible to preven vascular and lymphatic spread, and minimizing operative risk.

A

R0

27
Q

lumpectomy with radiation therapy is as effective as modified radical mastectomy for breast cancer. T/F

A

T

28
Q

Give 2 subsets of patients where surgery can be curative.

A

Resection of lung metastases from osteosarcoma
hepatic lobectomy in colon cancer patients with fewer than five liver metastases restricted to one lobe and no extrahepatic metastases

29
Q

Therapeutic radiation is delivered via focused beams of radiation generated at a distance and aimed at the tumor within the patient.

a. teletherapy
b. brachytherapy
c. systemic therapy

A

A

30
Q

Radioactive iodine is an example of

a. teletherapy
b. brachytherapy
c. systemic therapy

A

C

31
Q

Therapeutic radiation is delivered with encapsulated soruces of radiation implanted directly into or adjacent to tumor sites.

a. teletherapy
b. brachytherapy
c. systemic therapy

A

B. brachytherapy

32
Q

T/F radiation therapy is a local treatment therefore it’s effects are all local

A

F; may have systemic effects including anorexia, nausea, vomiting

33
Q

Which is the most radioresistant organ?

A

Bone

34
Q

What are the most radiosensitive organs?

A

male testis, female ovary

bone marrow

35
Q

T of chronic toxicities of radiation therapy

a. Radiation of the head and neck region often causes hyperthyroidism
b. It can cause blindness
c. Salivary glands are not affected
c. AOTA

A

B;

a. it can cause thyroid failure
c. salivary glands stop making saliva, may lead to dental caries and poor dentition

36
Q

T/F MI can be a sequelae of radiation therapy

A

T; mediastinal irradiation

37
Q

Use of focused microwave radiation to induce thermal injury within a volume of tissue

A

Radiofrequency ablation

38
Q

Use of extreme cold to sterilize lesions in certain sites such as prostate, kidney when at a very early stage, eliminating the need for modalities with more side effects such as surgery or irradiation

A

Cryosurgery

39
Q

Dose that conveys greater toxicity than would be acceptable in routine practice

A

Dose-limiting toxicity

40
Q

What is the most immediate indicator of drug effect/response?

A

Tumor shrinkage

41
Q

Decrease in tumor size by at least 50% is called

a. incomplete response
b. slight response
c. partial response
d. adequate response

A

C partial response

42
Q

Definition of complete response

A

disappearance of all tumor

43
Q

Definition of progression

A

increase in size of existing lesions by >25% from baseline or best response or development of new lesions

44
Q

What do you call the dose regimen of chemotherapy that produce reversible acute side effects

A

conventional dose regimens

45
Q

T/F High dose regimens have definite curative potential in defined clinical settings.

A

T

46
Q

3 goals of palliative therapy using chemotherapy

A
  1. improved symptom relief
  2. progression-free survival
  3. improved overall survival

M3 (66 decks)

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