Onco - Lung Bk Clin Man Flashcards
Top 3 presenting signs and symptoms of lung CA (table 74-4)
cough
weight loss
dyspnea
the ff contribute to signs symptoms or laboratory abnormalities in lung CA EXCEPT
a. primary lesion
b. local tumor growth
c. invasion
d. obstruction of adjacent structures
e. growth at distant metastatic sites
f. paraneoplastic syndrome
g. NOTA
G
True about clinical manifestations of lung CA
a. prototypical lung CA is a never smoker, female usually youger
b. a history of chronic cough with or without hemoptysis in a current or former smoker with chronic obstructive pulmonary disease age 40 years or older, but normal CXR, lung cancer workup is unnecessary.
c. Lung CA arising in a lifetime never smoker is more common in woman, east asians, and younger than their smoking counterparts
d. AOTA
C
a - current or former smoker of either sex, usually in the 7th decade of life
b. should evaluate for lung CA
cough, hemoptysis, wheeze, stridor, dyspnea, or post-obstructive pneumonitis, patients are typical manifestations of
central or endobronchial growth of the primary tumor
malignant pleural effusions can cause (3)
pain
dyspnea
cough
result from local extension of a tumor growing in the apex of the lung with involvement of the eighth cervical and first and second thoracic nerves, and present with shoulder pain that characteristically radiates in the ulnar distribution of the arm, often with radiologic destruction of the first and second ribs
Pancoast or superior sulcous tumor
2 coexisting sydromes in lung CA
Horner’s
Pancoast
Constitutional symptoms
FAWWN fever anorexia weight loss weakness night sweats
Extrathoracic metastatic disease found in
__% with squamous carcinoma
__% with adenocarcinoma
__% with large cell carcinoma
50
80
95
when patient presents with impairment of gas exchange, respiratory insufficiency dyspnea, hypoxemia and sputum production, what does this say about the tumor growth?
spread transbronchially, producing tumor growth along multiple alveolar surfaces
patient daignosed with lung CA developed headache, nausea, vomiting, seizures, neuro deficits
brain mets
patient with lung CA developed pain, pathologic fractures, cord compression
bone mets
patient with lung CA developed cytopenias or leukoerythroblastosis
bone marrow invasion
patient with lung CA developed hepatomegaly RUQ pain, fever, anorexia, weight loss,
liver mets;
note: liver dysfunction and biliary obstructions are rare
patient with lung CA developed adrenal insufficiency
adrenal metastases
