Onco - Lung Bk Chemo SI II NSCLC

Question 1

True of chemotherapy for Lung CA
according to LACE study, survival benefit for adjuvant chemotherapy compared to surgery alone is:
a. confined to stage III and IV
b. worsened in stage IA
c. worsened in Stage IB
d. NOTA

Answer 1

B; confined to stage II and III, worsened in IA only. modest benefit in Stage IB

Question 2

adjuvant chemotx was detrimental in px with poor performace status, ECOG= __

Answer 2

2

Question 3

Patient with resected stage IA or IB NSCLC, is adjuvant chemotherapy indicated?

Answer 3

No, unless stage IB with a resected lesion >=4cm

Question 4

When is adjuvant chemotherapy given?

Answer 4

6-12 weeks after surgery, assuming patient has fully recovered, should be administered for no more than 4 cycles

Question 5

What is the preferred chemo drug for adjuvant chemo for lung CA?

Answer 5

cisplatin-based chemotx

Question 6

Carboplatin can be substituted for cisplatin in patients who are unlikely to tolerate cisplatin for what reasons?

Answer 6

reduced renal function
presence of neuropathy
hearing impairment

Question 7

Most common drug combination for adjuvant chemo

Answer 7

platinum plus vinorelbine

Question 8

How should recurrences be screened?

Answer 8

contrast chest CT every 6 mos. for the first 3 years after surgery. followed by yearly CT scans of the chest without contrast thereafter