CMD - cough

Question 1

sensory nerve endings triggered, producing spontaneous coulgh

Answer 1

rapidly adapting receptors and C fibers.

Question 2

true about type 1 vanilloid receptor EXCEPT

a. receptor of capsaicin
b. found on rapidly adapting receptors and type C fibers
c. expression is increased with chronic cough
d. NOTA

Answer 2

D

Question 3

Cough center

a. locus ceruleus
b. vagus nerve nucleus
c. arnold nucleus
d. nucleus tractus solitarius

Answer 3

D

Question 4

Give 4 causes of impaired cough

Answer 4

decrased expiratory muscle strength
decreased inspiratory muscle strength
chest wall deformity
impaired glottic closure or tracheostomy
tracheomalacia
abnormal airway secretions
central respiratory depression

Question 5

Wheezing, SOB, chest tightness after exposure to allergens

Answer 5

Suggest asthma

Question 6

Acute cough

Answer 6

<3 weeks cough

Question 7

CHhronic cough

Answer 7

> 8 weeks cough

Question 8

3-8 weeks cough

Answer 8

subacute cough

Question 9

ddx for subacute cough (2)

Answer 9

residuum of tracheobronchitis as in pertussis

postviral tussive syndome

Question 10

these 4 conditions account for more than 90% of cases of chronic cough with a normal or noncontributory chest radiograph

Answer 10

ACE i
postnasal drainage
GER
Asthma

Question 11

ACE metabolizes _______ and other tachkinins such as ________

Answer 11

bradykinin, substance P

Question 12

ACE i cough is due to

Answer 12

accumulation of bradykinin

Question 13

polymorphisms in this gene are associated with ACE i induced cough

Answer 13

neurokinin-2 receptor gene

Question 14

This condition is characterized by sputum eosinophilia in excess of 3% without airflow obstruction or bronchial hyper responsiveness

Answer 14

Chronic eosinophilic bronchitis

Question 15

Chest radiograph of chronic eosinophilic bronchitis shows

Answer 15

normal CXR

Question 16

Tx of Chronic eosinophilic bronchitis

Answer 16

inhaled glucocorticoids

Question 17

an over the counter centrally acting cough suppressant with fewer side effects and less efficacy than narcotic cought suppressants

Answer 17

dextrmetorphan

Question 18

Thought to inhibit neural of sesonsory nerves in the cough-refelx pathway

Answer 18

Benzonatate

Question 19

Chronic idiopathic cough are treated with off-label use of

Answer 19

gabapentine

amitriptyline

Question 20

most effective for treatment of chronic idiopathic cough

Answer 20

narcotic cough suppresants such as hydrocodone