IDS TF Flashcards
Pathologic changes in the GI in typhoid fever that was the basis of its definition in the early 1800s
Enlarged Peyer’s patches and mesenteric lymph nodes
Etiologic agents of typhoid fever
Salmonella typhi
Salmonella paratypho serotypes A, B and C
Most common means of transmission of Salmonella
fecal contamination by ill or asymptomatic chronic carriers
True about typhoid fever
a. it can’t be sexually transmitted between male partners
b. previous H. pylori infection is a risk factor
c. more common in rural areas
d. more common among adults
B
Drugs not effective against MDR S. typhi
CAT
chloramphenicol
ampicillin
trimethoprim
Most common clinical manifestation of typhoid fever
fever
Most common GI manifestation of typhoid fever
anorexia
Incubation period of typhoid fever
10-14 days
characteristics of fever in typhoid fever
prolonged, up to 4 weeks
T 38.8degC to 40.5degC
Which one is to cause milder disease?
a. S. typhi
b. S. paratyphi A
B
Among these initial symptoms, which is most common?
a. chills
b. cough
c. sweating
d. headache
D
True of rose spots EXCEPT
a. it’s appears in 30% of patients
b. faint, salmon colored
c. non-blanching
d. maculopapular rash
e. appears at the end of the 1st week
C; blanching
Second most common clinical manifestation of typhoid fever
anorexia
when does relative bradycardia occur in typhoid fever?
At the peak of high fever
When does GI bleeding and instestinal perforation occur?
third and fourth week of illness
intestinal perforation occurs in what percentage of patients?
1-3%
Gi bleeding result from what pathologic changes in the initial site of Salmonella infiltration?
HUN
hyperplasia
ulceration
necrosis
Neuropsychiatric symptom in typhoid fever that involves picking at bed clothes or imaginary objects
coma vigil
muttering delirium
what percentage of typhoid fever patients will have mild relapse within 2-3 weeks of fever resolution, in association with the same strain type and susceptibility profile?
10%
For how long will S. typhi be found in the feces of 10% of untreated patients
3 months
Give 4 rare complications of typhoid fever
DIC hematophagocytic syndrome pancreatitis hepatic and splenic abscesses granulomas endocarditis pericarditis myocarditis orchitis hepatitis pyelonephritis hemolytic uremic syndrome severe pneumonia arthritis osteomyelitis endophthalmitis parotitis
The following can happen in typhoid fever EXCEPT
a. leukopenia
b. leukocytosis
c. neutropenia
d. AOTA
e. NOTA
E
Serologic test for typhoid that detect febrile agglutinins
Widal test
Most sensitive test for typhoid fever
antigen and nucleic acid ampilification tests
