Onco: Cancer Genetics

Question 1

______ normally promote normal cell growth; mutations convert them to oncogenes

Answer 1

proto-oncogenes

Question 2

______ normally restrain cell growth; loss of function results in unregulated growth

Answer 2

Tumor supressor genes

Question 3

______ alternatively known as a single nucleotide substitiution, and is a common mechanism of oncogene activation

Answer 3

point mutation

Question 4

_________ lead to overexpression of the gene product

Answer 4

DNA sequence amplification

Question 5

cytologically recognizable chromosome alterations referred to as ______ if integrated within chromosomes,

Answer 5

homogeneous straining regions

Question 6

ytologically recognizable chromosome alterations referred to as ______ if integrated outside chromosomes,

Answer 6

double minutes

Question 7

What malignancy is associated with

BCR-ABL 9:22 translocation

Answer 7

CML

Question 8

What malignancy is associated with

PAX3-FOXO1 , 2:13translocation

Answer 8

Rhabdomyosarcoma

Question 9

What malignancy is associated with

PAX8-PPARG
2:3 translocation

Answer 9

Thyroid